High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis

Vasseur, Philippe; Devaure, Iris; Sellier, J.; Delwail, Adriana; Chagneau‐Derrode, Carine; Charier, Florian; Tougeron, David; Tasu, Jean‐Pierre; Rabeony, Hanitriniaina; Lecron, Jean‐Claude; Silvain, Christine

doi:10.1016/j.pan.2014.08.005

Cited by 41 publications

(36 citation statements)

References 32 publications

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“…Therefore, finding an adequate balance between pro- and anti-inflammatory cytokines in the treatment of SAP may be a useful solution. In this study, IL-10 expression in the SAP group was slightly higher than that in the NC group as detected by ELISA, in line with previous studies (55,56). Of note, luteolin significantly increased the level of IL-10, which depends on HO-1 activity.…”

Section: Discussionsupporting

confidence: 93%

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

Xiong

Wang

Yuan

et al. 2016

International Journal of Molecular Medicine

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Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, acute lung injury, acute myocardial infarction and hepatitis. Luteolin, the main component of Reseda odorata L., which is also widely found in many natural herbs and vege tables, has been shown to induce heme oxygenase-1 (HO-1) expression to exert anti-inflammatory and antioxidant effects. In this study, we aimed to examine the effects of luteolin on mice with severe acute pancreatitis (SAP), and to explore the underlying mechanisms. Cerulein and lipopolysaccharide were used to induce SAP in male Institute of Cancer Research (ICR) mice in the SAP group. The SAP group was divided into 4 subgroups, as follows: the vehicle, luteolin, zinc protoporphyrin (ZnPP) only, and luteolin (Lut) + ZnPP (luteolin plus zinc protoporphyrin treatment) groups. The wet/dry weight ratios, hematoxylin and eosin staining and pathological scores of pancreatic tissues were assessed and compared to those of the control mice. Amylase, lipase, nuclear factor-κB (NF-κB) and myeloperoxidase activities, and malondialdehyde, tumor necrosis factor α (TNFα), interleukin (IL)-6, IL-10 and HO-1 levels, as well as the expression of HO-1 were determined in serum and/or pancreatic tissue samples. SAP was successfully induced in male mice compared to normal control mice. The wet/dry weight ratios, pathological scores, and amylase and lipase activity, as well as the levels of TNFα and IL-6 were significantly reduced in the pancreatic tissues of the mice in the Lut group compared with those of the mice in the vehicle group. The Lut group exhibited a significant increase in HO-1 expression in the pancreas and enhanced serum HO-1 and IL-10 levels compared with the vehicle group. The suppression of HO-1 activity in the ZnPP group significantly abolished the protective effects of luteolin. NF-κB expression in the pancreatic tissues from the mice in the Lut + ZnPP group was significantly increased following the suppression of HO-1 activity. On the whole, our findings demonstrate that luteolin protects mice from SAP by inducing HO-1-mediated anti-inflammatory and antioxidant activities, in association with the suppression of the activation of the NF-κB pathway.

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Section: Discussionsupporting

confidence: 93%

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

Xiong

Wang

Yuan

et al. 2016

International Journal of Molecular Medicine

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“…Furthermore, we determined four main inflammatory mediators in the serum of SAP rats: TNF-α, IL-6, IL-1β, and IL-10. All of these cytokines were previously reported to participate in the acute-phase response of SAP (7,(22)(23)(24)(25). IL-6 was elevated more than the other cytokines in this SAP rat model.…”

Section: Il-6 Expression After Sap Inductionsupporting

confidence: 49%

Effects of Tocilizumab on Experimental Severe Acute Pancreatitis and Associated Acute Lung Injury

Chen

Yang

et al. 2016

Critical Care Medicine

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“…In our model system IL-1ra may have dual functions. First it may attenuate inflammatory processes similar as it was shown for acute or chronic pancreatitis (Shen et al, 2012; Vasseur et al, 2014); and second it affects lesion growth. The latter may be due to activation of ERK1/2 signaling (Fig.…”

Section: Discussionmentioning

confidence: 83%

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

et al. 2017

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SUMMARY The contributions of the innate immune system to the development of pancreatic cancer are still ill-defined. Inflammatory macrophages can initiate metaplasia of pancreatic acinar cells to a duct-like phenotype (ADM), which then give rise to pancreatic intraepithelial neoplasia (PanIN) when oncogenic KRas is present. However, it remains unclear when and how this inflammatory macrophage population is replaced by tumor-promoting macrophages. We here demonstrate presence of interleukin-13 (IL-13), which can convert inflammatory into Ym1+ alternatively-activated macrophages, at ADM/PanIN lesions. We further show that Ym1+ macrophages release factors such as IL-1ra and CCL2 to drive pancreatic fibrogenesis and tumorigenesis. Treatment of mice expressing oncogenic KRas under an acinar cell-specific promoter with a neutralizing antibody for IL-13 significantly-decreased the accumulation of alternatively-activated macrophages at these lesions, resulting in decreased fibrosis and lesion growth.

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High plasma levels of the pro-inflammatory cytokine IL-22 and the anti-inflammatory cytokines IL-10 and IL-1ra in acute pancreatitis

Cited by 41 publications

References 32 publications

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

Luteolin protects mice from severe acute pancreatitis by exerting HO-1-mediated anti-inflammatory and antioxidant effects

Effects of Tocilizumab on Experimental Severe Acute Pancreatitis and Associated Acute Lung Injury

The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis

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