High-pressure studies of pharmaceutical compounds and energetic materials

Abstract

The effects of high pressure on pharmaceutical compounds and energetic materials can have important implications for both the properties and performance of these important classes of material. Pharmaceutical compounds are frequently subjected to pressure during processing and formulation, causing interconversion between solid forms that may affect properties such as solubility and bio-availability. Energetic materials experience extremes of both pressure and temperature under conditions of detonation and deflagration, causing changes in properties such as sensitivity to shock and chemical reactivity. This tutorial review outlines the various methods used to study these materials at high pressure, describes how pressure can be used to explore polymorphism, and provides examples of compounds that have been studied at high pressure.

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

“…Since these measurements are influenced by surface properties, the obtained results have to be supported with complementary techniques such as high-pressure diffraction (40)(41)(42)(43) or simulation approaches based on determination of crystal interplanar d-spacings, attachment or surface energy (44)(45)(46)(47).…”

High-pressure diffraction studies of molecular organic solids. A personal view

“…At the same time, they can find important applications in molecular electronics and in the pharmaceutical industry (Boldyreva & Boldyrev, 1999;Shakhtshneider et al, 1999;Hemley & Dera, 2000;Boldyreva, Shakhtshneider et al, 2000;Katrusiak, 2001;Boldyreva, 2003a,b;Fabbiani et al, 2003Fabbiani et al, , 2004Boldyreva, Drebushchak, Paukov et al, 2004;Boldyreva, Drebushchak, Shakhtshneider, Ahsbahs, Uchtmann et al, 2004;Fabbiani, Allan, Marshall et al, 2005Fabbiani et al, 2006Fabbiani et al, , 2007Boldyreva, 2006Boldyreva, , 2007a.…”

High-pressure crystallography

“…The development of science and technology increasingly relies on technologies involving extreme conditions, like extrusion of metal capillaries, syntheses of super-hard materials (Huppertz, 2004;Kim et al, 2007), production of components of jet engines and spacecraft coatings, and also in the search for new polymorphic forms of drugs (Boldyreva, Shakhtshneider, Ahsbahs, Sowa & Uchtmann, 2002;, pigments and energetic materials (Fabbiani & Pulham, 2006). For many years, variation of temperature has been the main manner of changing thermodynamical conditions in technological processes and structural studies.…”