High prevalence and low spontaneous eradication rate of <i>Helicobacter pylori</i> infection among schoolchildren aged 7–12 years

Zhou, Ying; Huang, Jie; Huang, Ying; Yan, Weili; Zhang, Yi

doi:10.1111/apa.14387

Cited by 20 publications

(21 citation statements)

References 16 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 1 The incidence of Hp infection in children in China is high; and its natural remission rate is low. 2 In recent years, the eradication rate of Hp infection has decreased. The eradication rate of Hp infection treated by triple therapy has been reported to be lower than 80%.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Zhang

Guo

et al. 2020

Pak J Med Sci

View full text Add to dashboard Cite

Objective: To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis. Methods: A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children’s Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence. Results: The levels of 25-(OH) D3 in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D3 in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D3 and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D3 and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05). Conclusion: Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D3 may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients. doi: https://doi.org/10.12669/pjms.36.6.2292 How to cite this:Zhang Y, Bi B, Guo X, Zhang S. Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Introductionmentioning

confidence: 99%

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Zhang

Guo

et al. 2020

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…Tang et al reported a statistically significant decrease in the H pylori infection rate in symptomatic children between 2005 (25.6%) and 2017 (12.8%) in China. However, infection rates remain higher in some groups of children, dependent on factors such as low socioeconomic status and bad sanitary conditions as was concluded in studies from Poland, Peru, China, and Ethiopia …”

Section: Epidemiologymentioning

confidence: 90%

“…The epidemiology of H pylori is rapidly changing, as shown by the high number of epidemiologic studies published in the last year. The world prevalence of H pylori varies significantly, from 2.5% in Japan to 34.6% in Ethiopia (Table ). Nonetheless, a decreasing trend in the prevalence of H pylori infection among children is being observed.…”

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Review: Helicobacter pylori in pediatrics

2019

View full text Add to dashboard Cite

Despite a decrease in the prevalence of Helicobacter pylori infection, it still poses a significant health burden worldwide. This review summarizes important pediatric studies on H pylori published from April 2018 to March 2019. Epidemiologic studies have reported different prevalences in different parts of the world and have mainly confirmed traditional risk factors. Several studies on pathophysiology attempted to identify risk markers in childhood for gastric cancer development later in life. One of the most interesting studies evaluated the relationship between eosinophilic esophagitis and H pylori infection; however, an inverse relationship was not confirmed. The high resistance of H pylori and, consequently, low eradication rates, is still a major concern and susceptibility testing before treatment has again been highlighted. Potassium‐competitive acid blockers are promising new acid‐suppressant drugs but their role in H pylori eradication schemes is still to be determined.

show abstract

“…Recent epidemiologic studies have reported a decreasing prevalence of pediatric H. pylori infection pointing out a significant difference between 25.6% in 2005 and 12.8% in 2017 [ 14 ]. Nevertheless, wide variations were reported among different populations in terms of prevalence mostly depending on the socio-economic status [ 7 , 8 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: New Insights On Pediatric H Pylori Infectionmentioning

confidence: 99%

Gastric Microenvironment—A Partnership between Innate Immunity and Gastric Microbiota Tricks Helicobacter pylori

Mărginean

Meliţ

Săsăran

2021

JCM

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) carcinogenicity depends on three major factors: bacterial virulence constituents, environmental factors and host’s genetic susceptibility. The relationship between microenvironmental factors and H. pylori virulence factors are incontestable. H. pylori infection has a major impact on both gastric and colonic microbiota. The presence of non-H. pylori bacteria within the gastric ecosystem is particularly important since they might persistently act as an antigenic stimulus or establish a partnership with H. pylori in order to augment the subsequent inflammatory responses. The gastric ecosystem, i.e., microbiota composition in children with H. pylori infection is dominated by Streptoccocus, Neisseria, Rothia and Staphylococcus. The impairment of this ecosystem enhances growth and invasion of different pathogenic bacteria, further impairing the balance between the immune system and mucosal barrier. Moreover, altered microbiota due to H. pylori infection is involved in increasing the gastric T regulatory cells response in children. Since gastric homeostasis is defined by the partnership between commensal bacteria and host’s immune system, this review is focused on how pathogen recognition through toll-like receptors (TLRs—an essential class of pathogen recognition receptors—PRRs) on the surface of macrophages and dendritic cells impact the immune response in the setting of H. pylori infection. Further studies are required for delineate precise role of bacterial community features and of immune system components.

show abstract

High prevalence and low spontaneous eradication rate of Helicobacter pylori infection among schoolchildren aged 7–12 years

Abstract: The prevalence of the H. pylori infection among Chinese schoolchildren aged 7-12 was high and spontaneous eradication was low.

Cited by 20 publications

References 16 publications

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Review: Helicobacter pylori in pediatrics

Gastric Microenvironment—A Partnership between Innate Immunity and Gastric Microbiota Tricks Helicobacter pylori

Contact Info

Product

Resources

About