High prevalence of capillary abnormalities in patients with diabetes and association with retinopathy

Barchetta, Ilaria; Riccieri, Valeria; Vasile, Massimiliano; Stefanantoni, Katia; Comberiati, Pasquale; Taverniti, L.; Cavallo, Maria Gisella

doi:10.1111/j.1464-5491.2011.03325.x

Cited by 60 publications

(68 citation statements)

References 16 publications

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“…This vascular heterogeneity may be related to significant autonomic neuropathy disturbances among population with this disease. Some other reports confirmed our results [2] [16].…”

Section: Discussionsupporting

confidence: 83%

“…Kaminska-Winciorek et al also showed an increased frequency of twisted capillaries in patients with diabetes type 1 and 2 [4]. Although we did not consider duration of disease, coiled capillaries were significantly reported in patients with diabetes with long-standing disease [18]. Of all participants 17% had different degrees of advanced microcirculation angiopathy (scleroderma pattern) that warned us for more attention against consequence complications.…”

Section: Discussionmentioning

confidence: 99%

“…We suppose that many factors like duration or severity of disease may be involved in micro circulation impairment. Barchettast et al showed greater alterations of capillary length (P = 0.004), distribution (P = 0.02), and morphology (P = 0.0001) in their subjects with diabetes [18].…”

Section: Discussionmentioning

confidence: 99%

“…Kaminska-Winciorek et al and Barchetta et al depicted that microcirculation alterations revealed by nailfold capillaroscopy was independent from age and sex in patients affected by diabetes [4] [16].…”

Section: Discussionmentioning

confidence: 99%

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Nailfold Capillaroscopy Findings in Diabetic Patients (A Pilot Cross-Sectional Study)

Rajaei¹,

Dehghan²,

Farahani³

2015

OJPathology

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Background: Microcirculation is affected in diabetes mellitus and Microvascular abnormalities cause persistent diabetic complications. The aim of this study was nailfold capillaroscopic assessment to describe the pathological changes (morphological and structural) in capillary of a large series of patients with type 1 and 2 diabetes. Methods: A cross-sectional study was carried out in a Nailfold Capillaroscopy Center (Tehran-Iran) between 2011 and 2014. The study included 235 types 1, 2 diabetic patients. All patients underwent 10 nailfolds capillaroscopy examinations. Microvascular architecture, disturbances capillary distribution, capillary morphology, capillary density, efferent/afferent limb ratio, sub-papillary venular plexus, and morphological abnormalities were evaluated. Conclusions were stated as normalor scleroderma pattern. Results of patients' capillaroscopic images were recorded and analyzed quantitatively and qualitatively. P value < 0.05 was considered as statistical significance. Results: of all participants with mean age 59.91 ± 12.39, 183 cases (77.9%) were female and 52 (22.1%) were male. Tortuosity of capillaries was more often observed in our subjects (235 cases) followed by angiogenesis (171 cases). Normal and early scleroderma patterns were observed in 195 (83.0%) and 40 cases (17.0%). Based on P values, altered micro vascular architecture, capillary distribution and capillary morphology were more frequent in patients with scleroderma pattern in comparison to patients with normal pattern (P value < 0.05). Morphological abnormalities except from neo formation capillary and mega capillary were also significantly more common in patients with scleroderma pattern than patients in counterpart group (P value < 0.05). Conclusion: Nailfold capillaroscopy as a non-invasive, diagnostic and prognostic method may potentially affect on diabetes outcome and control.

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“…This vascular heterogeneity may be related to significant autonomic neuropathy disturbances among population with this disease. Some other reports confirmed our results [2] [16].…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nailfold Capillaroscopy Findings in Diabetic Patients (A Pilot Cross-Sectional Study)

Rajaei¹,

Dehghan²,

Farahani³

2015

OJPathology

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“…[25][26][27][28] No subjects had manifest diabetic retinopathy, which may indicate systemic microvasculopathy. 29 XFS/XFG patients demonstrated XFM on slit lamp examination by an ophthalmologist at recruitment. POAG patients had no secondary cause for elevated IOP on anterior segment examination and no secondary cause for optic nerve disease on posterior segment examination.…”

Section: Study Design and Samplementioning

confidence: 99%

Nailfold capillary morphology in exfoliation syndrome

Cousins

Kang

Bovee

et al. 2017

Eye

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Purpose The purpose of the study was to investigate nailfold microvascular morphology in exfoliation syndrome with or without glaucoma (XFS/XFG) compared with primary open-angle glaucoma (POAG) and control subjects using nailfold capillary videomicroscopy. Patients and methods We used a JH-1004 capillaroscope to perform nailfold capillary videomicroscopy on the fourth and fifth digit of the non-dominant hand. We enrolled 56 XFS/XFG patients, 87 POAG patients, and 75 control subjects. Masked observers graded the videos for hemorrhages, avascular zones ≥ 200 microns (μm), and degree of microvascular tortuosity on a four-point subjective scale. Multivariable odds ratios, 95% confidence intervals and P-for trends for assessing the relation between morphological changes and POAG or XFS/XFG were obtained from logistic regression analyses. We also assessed this relation with XFS/XFG compared with POAG in multivariable models. Results After adjusting for multiple covariates, nailfold hemorrhages, avascular zones ≥ 200 μm, and higher degree of vascular tortuosity were more common in XFS/XFG vs controls (P-for trend ≤ 0.0001) and in POAG vs controls (P-for trend ≤ 0.01). For each 100 capillaries, the number of hemorrhages was similar (P-for trend = 0.91) between XFS/XFG and POAG patients; however, there were more avascular zones per 100 capillaries with borderline significance (P-for trend = 0.04) in the XFS/XFG group. XFS/XFG patients had more tortuosity than POAG patients; specifically, having a tortuosity score ≥ 1.5 was associated with a 4.4-fold increased odds of XFS/XFG (95% confidence interval: 1.5-13.3) relative to a tortuosity score o1.0 (P-for trend = 0.005). Conclusion A high degree of nailfold capillary tortuosity is a distinct non-ocular feature associated with XFS/XFG compared with either POAG or controls.

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Biophotonics methods for functional monitoring of complications of diabetes mellitus

Zharkikh

Dremin

Zherebtsov

et al. 2020

Journal of Biophotonics

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The prevalence of diabetes complications is a significant public health problem with a considerable economic cost. Thus, the timely diagnosis of complications and prevention of their development will contribute to increasing the length and quality of patient life, and reducing the economic costs of their treatment. This article aims to review the current state-of-the-art biophotonics technologies used to identify the complications of diabetes mellitus and assess the quality of their treatment. Additionally, these technologies assess the structural and functional properties of biological tissues, and they include capillaroscopy, laser Doppler flowmetry and hyperspectral imaging, laser speckle contrast imaging, diffuse reflectance spectroscopy and imaging, fluorescence spectroscopy and imaging, optical coherence tomography, optoacoustic imaging and confocal microscopy. Recent advances in the field of optical noninvasive diagnosis suggest a wider introduction of biophotonics technologies into clinical practice and, in particular, in diabetes care units.

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High prevalence of capillary abnormalities in patients with diabetes and association with retinopathy

Abstract: A high prevalence of nailfold capillary changes is detected in patients with diabetes using nailfold videocapillaroscopy. These abnormalities tightly correlate with retinal damage and may be expression of a generalized microvessel involvement in both Type 1 and Type 2 diabetes.

Cited by 60 publications

References 16 publications

Nailfold Capillaroscopy Findings in Diabetic Patients (A Pilot Cross-Sectional Study)

Nailfold Capillaroscopy Findings in Diabetic Patients (A Pilot Cross-Sectional Study)

Nailfold capillary morphology in exfoliation syndrome

Biophotonics methods for functional monitoring of complications of diabetes mellitus

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