High prevalence of celiac disease in Swedish children and adolescents with type 1 diabetes and the relation to the Swedish epidemic of celiac disease: a cohort study

Abstract

The onset of CD in the T1DM population does not follow the pattern of the general population during the Swedish epidemic of CD. The shared genetic component in the human leukocyte antigen region in cases with comorbidity of CD and T1DM may overrule other CD-causing factors in the general population. Children with T1DM should be screened for CD at diagnosis and repeatedly at least during the first 2 years, even if asymptomatic.

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members

“…Our results confirm the Australian and Swedish reports on differing gender distribution; both boys and girls were equally often affected among children with both T1D and CD in contrast to the usual female predominance of CD . However, in Italy and Estonia an increased risk for CD has been reported among girls with T1D .…”

Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease

“…It is tempting to speculate that the ingestion of gluten lowers the gut barrier and increases the risk of being exposed to other antigens involved in the pathogenesis of type 1 diabetes. However, this speculation does not tie in with the fact that the incidence of coeliac disease and type 1 diabetes did not follow the same pattern during the high incidence years (30).…”

Celiac disease, collagenous sprue and microscopic colitis in IBD. Observations from a population-based cohort of IBD (ICURE)

“…In a recent Swedish study comprising a target population of 1151 children, 847 individuals accepted to take part of a screening study for celiac disease [21]. It was found that 9.1% of those accepting to be investigated were affected (6.7% of the whole population).…”