High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome

Garelli, Silvia; Masiero, Stefano; Plebani, Mario; Chen, Shu; Furmaniak, Jadwiga; Armanini, Decio; Betterle, Corrado

doi:10.1016/j.ejogrb.2013.03.003

Cited by 69 publications

(67 citation statements)

References 34 publications

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“…Singla et al [13] found that females with PCOS have higher thyroid antibody levels, larger thyroid volumes and their thyroids were more hypoechogenic (compatible with thyroiditis) when compared to controls. Similarly, ATPO have been shown to be present in 27 % of the patients when compared to 8 % in controls in a study done by Garelli et al [16].…”

Section: Discussionmentioning

confidence: 76%

Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome

Menon

Ramachandran

2016

J Obstet Gynecol India

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Objective To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group. Methods Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013-Feb 2014. Ninety cases of women with PCOS based on Rotterdam's criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques. Results Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (p \ 0.0001). Hyperandrogenism was the second most common manifestation present in PCOS of our study group. Hirsutism was the striking hyperandrogenic feature that was present in study group. PCOS patients had higher BMI compared to controls (p \ 0.0001). The prevalence of thyroid dysfunction was not significantly different in both the groups (p \ 0.80). Anti-TPO titre was higher in PCOS patients (25.8 ± 2.9 IU/ml) compared to the controls (14.5 ± 2.3 IU/ml) (p \ 0.009). Conclusion The present study shows that PCOS was associated with increased anti-TPO titres, thus emphasising the importance of screening all PCOS patients for anti-TPO along with routine thyroid profile.

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Section: Discussionmentioning

confidence: 76%

Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome

Menon

Ramachandran

2016

J Obstet Gynecol India

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“…Taken together, the prevalence of HT in PCOS patients was found to be increased by threefold when compared with controls (19). Recently, the higher prevalence of HT in women with PCOS than in controls was confirmed in 113 Italian patients with the mean age of 24 years and in 100 controls (27 vs 8%) (20). Out of 168 young Brazilian PCOS women with the mean age of 24 years, 149 (88.7%) had normal thyroid function and 19 (11.3%) subclinical hypothyroidism with TSH levels between 4.5 and 10 mIU/l, representing a higher prevalence of subclinical hypothyroidism in PCOS than in the general population (21).…”

Section: Joint Prevalencementioning

confidence: 83%

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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Thyroid disorders, especially Hashimoto's thyroiditis (HT), and polycystic ovary syndrome (PCOS) are closely associated, based on a number of studies showing a significantly higher prevalence of HT in women with PCOS than in controls. However, the mechanisms of this association are not as clear. Certainly, genetic susceptibility contributes an important part to the development of HT and PCOS. However, a common genetic background has not yet been established. Polymorphisms of the PCOS-related gene for fibrillin 3 (FBN3) could be involved in the pathogenesis of HT and PCOS. Fibrillins influence the activity of transforming growth factor beta (TGFb). Multifunctional TGFb is also a key regulator of immune tolerance by stimulating regulatory T cells (Tregs), which are known to inhibit excessive immune response. With lower TGFb and Treg levels, the autoimmune processes, well known in HT and assumed in PCOS, might develop. In fact, lower levels of TGFb1 were found in HT as well as in PCOS women carrying allele 8 of D19S884 in the FBN3 gene. Additionally, vitamin D deficiency was shown to decrease Tregs. Finally, high estrogen-to-progesterone ratio owing to anovulatory cycles in PCOS women could enhance the immune response. Harmful metabolic and reproductive effects were shown to be more pronounced in women with HT and PCOS when compared with women with HT alone or with controls. In conclusion, HT and PCOS are associated not only with respect to their prevalence, but also with regard to etiology and clinical consequences. However, a possible crosstalk of this association is yet to be elucidated.

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“…Metabolic disorders associated with PCOS include hyperinsulinaemia, insulin resistance, impaired pancreatic cell insulin secretion, type 2 diabetes [2]. In addition, disorders of general health such as preeclampsia and chronic thyroiditis [3,4] are also shown in association with PCOS. The observation of familial aggregation indicates heritable tendency of the PCOS, but the etiology and pathogenesis remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

Guruvaiah

Govatati

Reddy

et al. 2014

J Assist Reprod Genet

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Purpose The aim of this study was to investigate the association between two common single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene (−460C/T and +405G/C) and polycystic ovary syndrome (PCOS) risk in south Indian women. Methods This study involves clinically confirmed PCOS patients (n=126) and non-PCOS controls (n=130) of south Indian origin (Dravidian linguistic group). Genotyping of the VEGF gene −460C/T and +405G/C SNPs were performed by PCR and sequencing analysis. Haplotype frequencies for multiple loci and the standardized disequilibrium coefficient (D') for pairwise linkage disequilibrium (LD) were assessed by Haploview Software. Results The frequencies of +405G/G genotype (P=0.03) and +405G alleles (P=0.006) were significantly higher in patients compared to controls. Whereas the genotype and allele frequencies of −460C/T SNP were not significantly different between patients and controls. In addition, LD analysis revealed no significant difference between patients and controls. Conclusion Our findings suggest that the VEGF +405G/C polymorphism may constitute an inheritable risk factor for PCOS in south Indian women.

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High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome

Cited by 69 publications

References 34 publications

Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome

Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

The VEGF +405 G>C 5' untranslated region polymorphism and risk of PCOS: a study in the South Indian Women

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