High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

Ribeiro, Mariana Goveia Melo; Marcolino, Larissa Doddi; Ramos, Bruna Ribeiro de Andrade; Miranda, Elaine Alves; Trento, Cléverson Luciano; Jain, Sona; Gurgel, Ricardo Queiróz; Silva, Márcia Guimarães da; Dolabella, Silvio Santana

doi:10.1590/1678-77572016-0313

Cited by 9 publications

(7 citation statements)

References 26 publications

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“…A lower but significantly different prevalence of oral HPV in oral lesions was found among Croatian individuals (17%) and Chilean patients (11%) with oral cancer [22,23]. However, in a Brazilian study, it was found the highest prevalence of oral lesions from South America (81%) [24].…”

Section: Discussionmentioning

confidence: 88%

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Mosmann

Talavera

Criscuolo

et al. 2019

Journal of Oral Microbiology

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Objective: Provide evidence of HPV, C. trachomatis, and HSV infection in the oral cavity from patients with different types of stomatological lesions. Materials and Methods: Oral swabs samples were collected from a total of 318 patients. The infectious agents were analyzed using the PCR technique. HPV genotyping and HSV type were studied using the RFLP method. Results: We studied 137 benign lesions (B), 96 potentially malignant disorders (PMD) and 85 oral squamous cell carcinomas (OSCC). The prevalence of HPV was 34%. The most frequently genotypes detected were 6 low risk and 16 high risk. The prevalence of C. trachomatis was 16% and HSV 3%. Co-infections were detected mostly in benign lesions as following: HPV-C. trachomatis in 4%, C. trachomatis-HSV in 1.8% and HPV-HSV in 0.3%. Conclusion: This report is the first contribution to the identification and genotype characterization of HPV in a scenario little studied in our area, and it also contributes to improving our understanding on sexually transmitted infectious agents and their associations with the oral cavity. Besides, we detect the presence of C. trachomatis and HSV and co-infection with HPV in the oral cavity, which they should be taken into account for diagnostic and treatment purposes.

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Section: Discussionmentioning

confidence: 88%

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Mosmann

Talavera

Criscuolo

et al. 2019

Journal of Oral Microbiology

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“…However, in the case of the third pathogen investigated here, the human papillomavirus (HPV), no systematic association has been established[ 6 , 22 - 24 ]. While the oncogenic properties of HPV have been demonstrated in studies of other portions of the digestive tract[ 25 - 28 ], its possible relationship with GC is still unclear[ 23 , 24 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Association betweenHelicobacter pylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas

Souza

Almeida

Khayat

et al. 2018

WJG

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AIMTo correlate Helicobacter pylori (H. pylori), Epstein-Barr virus (EBV) and human papillomavirus (HPV) with gastric cancer (GC) cases in Pará State, Brazil.METHODSTissue samples were obtained from 302 gastric adenocarcinomas. A rapid urease test was used to detect the presence of H. pylori, and the presence of the cagA gene in the HP-positive samples was confirmed by PCR. An RNA in situ hybridization test designed to complement Eber1 RNA was used to detect the presence of EBV in the samples, and the L1 region of HPV was detected using nested PCR. Positive HPV samples were genotyped and analyzed for E6 and E7 viral gene expression. Infections were also correlated with the clinical and pathological characteristics of the patients.RESULTSThe majority of the 302 samples analyzed were obtained from men (65%) aged 55 years or older (67%) and were classified as the intestinal subtype (55%). All three pathogens were found in the samples analyzed in the present study (H. pylori: 87%, EBV: 20%, HPV: 3%). Overall, 78% of the H. pylori-positive (H. pylori+) samples were cagA+ (H. pylori-cagA+), and there was an association between the cytotoxic product of this gene and EBV. Coinfections of H. pylori-cagA+ and EBV were correlated with the most advanced tumor stages. Although only 20% of the tumors were positive for EBV, infection with this virus was associated with distant metastasis. Only the HPV 16 and 18 strains were found in the samples, although no expression of the E6 and E7 oncoproteins was detected. The fundus of the stomach was the region least affected by the pathogens.CONCLUSIONHPV was not involved in gastric tumorigenesis. Prophylactic and therapeutic measures against H. pylori and EBV may prevent the development of GC, especially the more aggressive forms.

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“…This is probably associated to the fact that from the more than 170 genotypes described, we used in this study only a limited number of probes, and it is unknown with certainty what percentage of the genome is common for those genotypes not commercially available. High discrepancies are found when using methods such as ISH or PCR, as the latter possess a higher sensitivity but lower specificity, and studies using PCR shows higher percentages of positivity (19). In conclusion, low-risk HPV 6/11 are the most common subtypes found in the oral cavity, even though, a small percentage of hyperplastic papillary lesions are associated with HPV, they comprise a wide group of lesions that deserves further studies to better clarify its classification and etiology.…”

Section: Discussionmentioning

confidence: 99%

Benign epithelial oral lesions – association with human papillomavirus

Piña¹,

Fonseca²,

Pontes³

et al. 2019

Med Oral

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Background The presence of human papilloma virus in benign oral lesions has been studied by different techniques obtaining extremely variable results. The objective of this study was to determine the presence of human papillomavirus in 83 cases of benign hyperplastic epithelial oral lesions. Material and Methods Eighty-three oral lesions with clinical or histopathological features suggestive of HPV infection were retrieved from the files of four oral pathology services. Demographic data were obtained from patient´s medical charts. All cases had available clinical image, H&E preparations and paraffin blocks with enough tissue for HPV detection by in situ hybridization, and immunohistochemical reactions for Ki67. Results Episomal positivity for wide spectrum HPV was observed in 24% of the cases; most of them (70%) HPV 6/11 positive. HPV 16/18 was not detected. Condyloma acuminatum was the most common lesion associated with HPV (75%), followed by verruca vulgaris (15%), squamous papilloma and multifocal epithelial hyperplasia, 5% each. Koilocytes were identified in all the HPV positive cases. Ki67 showed an abnormal proliferation pattern in 90% of the HPV positive cases; most of them (70%) showing groups of proliferating cells in focal superficial regions, and in 20% positivity was seen almost in the whole thickness of the epithelium. HPV negative cases showed Ki67 positive cells restricted to the basal layer. Conclusions Regarding oral lesions associated with HPV, condyloma is the most common lesion expressing low-risk subtypes. The etiology of squamous papilloma remains controversial as HPV was found in 1.9% of the cases. The identification of koilocytes and the pattern of expression of Ki67 reflect HPV infection and are helpful for classification. Papillary oral lesions not associated to HPV deserve further studies to better clarify its etiology. Key words: Human papillomavirus, condyloma, papilloma.

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High prevalence of human papillomavirus (HPV) in oral mucosal lesions of patients at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Northeastern Brazil

Cited by 9 publications

References 26 publications

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Sexually transmitted infections in oral cavity lesions: Human papillomavirus,Chlamydia trachomatis, and Herpes simplex virus

Association betweenHelicobacter pylori, Epstein-Barr virus, human papillomavirus and gastric adenocarcinomas

Benign epithelial oral lesions – association with human papillomavirus

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