High prevalence of IgE antibodies among blood donors in Sweden and Norway

Johansson, S. G. O.; Nopp, Anna; Florvaag, Erik; Lundahl, Joachim; Söderström, T; Guttormsen, Anne Berit; Hervig, Tor; Lundberg, María; Öman, H.; Hage, Marianne van

doi:10.1111/j.1398-9995.2005.00896.x

Cited by 46 publications

(41 citation statements)

References 9 publications

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“…Serum samples were analysed at the Laboratory of Clinical Biochemistry at Haukeland University Hospital for serum IgE (kU/l) and IgE antibody levels by the Immuno-CAP FEIA system (Phadia, Uppsala, Sweden). Allergen-speciWc IgE was tested for the main inhalation allergens using Phadiatop ® (Dermatophagoides pteronyssinus (d1), D. farinae (d2), birch (t3), timothy (g6), mugwort (w6), cat (e1), dog (e2), horse (e3), and Cladosporium (m2)) (Johansson et al 2005). Results were assessed as negative when the total concentration of the diVerent IgE antibodies was <0.35 kU A /l (kU A = kilounits of speciWc antigen) or positive when concentration waş 0.35 kU A /l.…”

Section: Questionnairementioning

confidence: 99%

“…This can be performed by means of testing allergen-speciWc IgE with a mixture of common inhalant allergens such as in Phadiatop ® (Johansson et al 2005). The presence of IgE antibodies does not necessarily mean clinically active disease but have clinically predictive value for developing characteristic symptoms and to react on allergens corresponding to the speciWc IgE antibodies (Johansson et al 2004).…”

Section: Introductionmentioning

confidence: 98%

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Atopy, symptoms and indoor environmental perceptions, tear film stability, nasal patency and lavage biomarkers in university staff

Bakke

Wieslander

Norbäck

et al. 2007

Int Arch Occup Environ Health

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BUT and NAL-lysozyme was associated with ocular, nasal, laryngeal symptoms and indoor environmental perceptions. Ever having had asthma and ever having had hay fever were predictors for symptoms and perceived air quality, respectively. Phadiatop, Total IgE, familiar allergy and ever eczema were not associated to symptoms or perceived environments. Age, gender and Phadiatop were main predictors for ocular and nasal biomarkers.

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Section: Questionnairementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Atopy, symptoms and indoor environmental perceptions, tear film stability, nasal patency and lavage biomarkers in university staff

Bakke

Wieslander

Norbäck

et al. 2007

Int Arch Occup Environ Health

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show abstract

“…Allergic reactions can occur after a patient ingests or inhales these allergens. One study found that 23% of donors had significant levels of IgE antibodies to common allergens (Johansson et al, 2005a). Therefore, the risk of passive sensitization by blood and plasma transfusion is probably not low.…”

Section: Passive Sensitizationmentioning

confidence: 99%

Current Understanding of Allergic Transfusion Reactions: Incidence, Pathogenesis, Laboratory Tests, Prevention and Treatment

文也¹

2013

JJTC

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SummaryNon-haemolytic transfusion reactions are the most common type of transfusion reaction and include transfusion-related acute lung injury, transfusion-associated circulatory overload, allergic reactions, febrile reactions, post-transfusion purpura and graft-versus-host disease. Although life-threatening anaphylaxis occurs rarely, allergic reactions occur most frequently. If possible, even mild transfusion reactions should be avoided because they add to patients' existing suffering. During the last decade, several new discoveries have been made in the field of allergic diseases and transfusion medicine. First, mast cells are not the only cells that are key players in allergic diseases, particularly in the murine immune system. Second, it has been suggested that immunologically active undigested or digested food allergens in a donor's blood may be transferred to a recipient who is allergic to these antigens, causing anaphylaxis. Third, washed platelets have been shown to be effective for preventing allergic transfusion reactions, although substantial numbers of platelets are lost during washing procedures, and platelet recovery after transfusion may not be equivalent to that with unwashed platelets. This review describes allergic transfusion reactions, including the above-mentioned points, and focusses on their incidence, pathogenesis, laboratory tests, prevention and treatment.

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“…In one Scandinavian study, as many as 27% of donors had IgE antibodies to 1 of 14 common allergens, which included food, medication and inhalant allergens. 5 A Canadian study found high rates of self-reported allergies among donors. 6 Theoretically, the risk of symptomatic passive transfer of IgE from transfusions would be high because of the large number of atopic blood donors.…”

Section: Key Pointsmentioning

confidence: 99%