High prevalence of increased interleukin-17A serum levels in postmenopausal estrogen deficiency

Molnár, Ildikó; Bohaty, Ilona; Somogyine-Vari, Eva

doi:10.1097/gme.0000000000000125

Cited by 53 publications

(35 citation statements)

References 21 publications

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“…In the meantime, we also found that serum IL-17A was negatively correlated with the T scores of lumbar spine BMD, which was consistent with the study findings by Ildiko'Molna'r et al [23]. Despite the very limited number of IL-17 studies in patients with osteoporosis, IL-17 studies in animal models and cell cultures supported our research findings.…”

Section: Discussionsupporting

confidence: 94%

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Zhang¹,

Fu²,

Ren³

et al. 2014

Gynecological Endocrinology

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Our experiments have confirmed the roles of IL-17 in the pathogenesis of postmenopausal osteoporosis and in the promotion of bone resorption. Targeted therapy of IL-17, IFN-γ, and IL-4 may be beneficial in the treatment of patients with postmenopausal osteoporosis. Our experiments have also confirmed the roles of IFN-γ and IL-4 in the pathogenesis of postmenopausal osteoporosis and in the inhibition of bone resorption.

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Section: Discussionsupporting

confidence: 94%

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Zhang¹,

Fu²,

Ren³

et al. 2014

Gynecological Endocrinology

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“…The change in circulating IL-17 level in the context of estrogen deprivation was frequently reported in animal studies [18] . Our study observed a significant rise in circulating IL-17 level in osteoporotic postmenopausal women, which was consistent with recent findings [19,25,26] . IL-17 can directly promote the production of RANKL by osteoblasts [17,18,27,28] .…”

Section: Discussionsupporting

confidence: 82%

Upregulated Cellular Expression of IL-17 by CD4+ T-Cells in Osteoporotic Postmenopausal Women

Zhao

Xin-zheng

Feng³

2016

Ann Nutr Metab

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Aim: The study aimed to investigate cellular expression of IL-17 by CD4+ T-cells in osteoporotic postmenopausal women. Methods: We enrolled 25 postmenopausal women with osteoporosis (PostMO) and 25 postmenopausal women with normal bone mineral density measurements (PostM) to examine the production of IL-17, tumor necrosis factor a (TNFa) and receptor activator of nuclear factor γ-B ligand (RANKL) by CD4+ T-cells and IL-17, RORγt, TNFa and RANKL mRNA levels in CD4+ T-cells. Circulating concentrations of IL-17 along with IL-6, TNFa, RANKL and osteoprotegerin (OPG) were also determined. Results: Osteoporotic postmenopausal women had higher serum concentrations of IL-17 (3.7 ± 1.3 vs. 2.5 ± 1.1 ng/ml, p = 0.042), IL-6 (158 ± 56 vs. 105 ± 39 pg/ml, p = 0.044), TNFa (138 ± 41 vs. 74 ± 11 pg/ml, p < 0.001) and OPG (1.7 ± 0.4 vs. 1.3 ± 0.4 ng/ml, p = 0.039) than healthy controls. The IL-17-producing CD4+ T-cells were higher in the PostMO group than in the PostM group (7.1 ± 2.4 vs. 4.9 ± 1.4%, p = 0.0015). Additionally, osteoporotic postmenopausal women had greater mRNA levels of IL-17 (3.5 ± 2.9 vs. 1.2 ± 1.0%, p = 0.019) and RORγt (5.7 ± 2.5 vs. 2.2 ± 1.0%, p < 0.001) in CD4+ T-cells than in healthy controls. Conclusions: Our findings implied that the upregulated production of IL-17 may play an important role in regulating bone loss in osteoporotic postmenopausal women.

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“…Another factor responsible for the bone loss induced by estrogen deficiency is IL-17, the signature cytokine of Th17 cells (47), which are an osteoclastogenic subset of CD4 + T cells (45,46). Intriguingly, postmenopausal women with osteoporosis exhibit elevated levels of serum IL-17 (66)(67)(68). In mice, ovx expands Th17 cells by promoting the differentiation of naive CD4 + T cells into mature Th17 cells (69), a phenomenon driven by cytokines such as TGFβ, IL-6, IL-1β, and TNF (43,44,47,70) -factors that are all disregulated by estrogen deficiency (25).…”

Section: Discussionmentioning

confidence: 99%

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

Li¹,

Chassaing²,

Tyagi³

et al. 2016

Journal of Clinical Investigation

491

610

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High prevalence of increased interleukin-17A serum levels in postmenopausal estrogen deficiency

Abstract: The results demonstrate a high prevalence of increased serum IL-17A levels in postmenopausal estrogen deficiency, which can play an inducing role in chronic inflammatory events such as bone loss.

Cited by 53 publications

References 21 publications

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Changes of serum cytokines-related Th1/Th2/Th17 concentration in patients with postmenopausal osteoporosis

Upregulated Cellular Expression of IL-17 by CD4+ T-Cells in Osteoporotic Postmenopausal Women

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

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