High Prevalence of Lipid Disorders in Type 1 Diabetes—Time for Treatment?

Bajpai, Anurag

doi:10.1007/s12098-022-04373-z

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The lipid metabolism is commonly deranged in diabetic conditions due to lack of insulin to regulate the synthesis and breakdown of lipid in adipose tissues, thereby causing dyslipidaemia leading to atherosclerosis 19 . In view of the lipid pro le, diabetic rats exhibited marked elevation of serum total cholesterol and total triglyceride level.…”

Section: Discussionmentioning

confidence: 99%

Influence of Rutin and its Combination with Metformin on Vascular Functions in Type 1 Diabetes

David

Chellian

et al. 2023

Preprint

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The present work examined the effect of oral administration of rutin and its combination with metformin, an antidiabetic drug on blood glucose, total cholesterol and triglycerides level and vascular function in streptozotocin (STZ) -induced diabetic rats. Male Sprague Dawley rats were rendered diabetic by a single intraperitoneal injection of STZ (50 mg/kg). Rutin and metformin were orally administered to diabetic rats at a dose of 100 mg/kg and 300 mg/kg body weight/day, respectively, for 4 weeks. Plasma analysis was conducted to determine changes in the plasma glucose and lipid levels. Rat aortic ring reactivity in response to endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) relaxants, and to the α1-adrenergic agonist phenylephrine (PE) were recorded. Histology of pancreas, liver and kidney were evaluated. In results, rutin and metformin alone and in combination has led to significant deterioration in blood glucose, cholesterol and triglyceride levels compared to diabetic and normal control. Diabetic aortic rings showed significantly greater contraction in response to PE, and less relaxation in response to ACh and SNP. Treatment with rutin and metformin in combination significantly reduced PE-induced contraction and increased ACh-induced and SNP-induced relaxation in diabetes when compared to rutin or metformin alone. Better histological improvements were recorded with combination treatment. In conclusion, rutin and metformin combination therapy has the most potentiality for restoring blood glucose and lipid level as well as vascular function.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Rutin and its Combination with Metformin on Vascular Functions in Type 1 Diabetes

David

Chellian

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The lipid metabolism is commonly deranged in diabetic conditions due to lack of insulin to regulate the synthesis and breakdown of lipid in adipose tissues, thereby causing dyslipidaemia leading to atherosclerosis 19 . In view of the lipid profile, diabetic rats exhibited marked elevation of serum total cholesterol and total triglyceride level.…”

Section: Discussionmentioning

confidence: 99%

Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes

David

Lai

Chellian

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The present work examined the effect of oral administration of rutin and its combination with metformin, an antidiabetic drug on blood glucose, total cholesterol and triglycerides level and vascular function in streptozotocin (STZ) -induced diabetic rats. Male Sprague Dawley rats were rendered diabetic by a single intraperitoneal injection of STZ (50 mg/kg). Rutin and metformin were orally administered to diabetic rats at a dose of 100 mg/kg and 300 mg/kg body weight/day, respectively, for 4 weeks. Plasma analysis was conducted to determine changes in the plasma glucose and lipid levels. Rat aortic ring reactivity in response to endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) relaxants, and to the α1-adrenergic agonist phenylephrine (PE) were recorded. Histology of pancreas, liver and kidney were evaluated. In results, rutin and metformin alone and in combination has led to significant improvements in blood glucose, cholesterol and triglyceride levels compared to diabetic group. Diabetic aortic rings showed significantly greater contraction in response to PE, and less relaxation in response to ACh and SNP. Treatment with rutin and metformin in combination significantly reduced PE-induced contraction and increased ACh-induced and SNP-induced relaxation in diabetes when compared to rutin or metformin alone. Significant histological improvements were seen with combination therapy. In conclusion, rutin and metformin combination therapy has the most potentiality for restoring blood glucose and lipid level as well as vascular function.

show abstract

Combination Therapy with Vitamin D and Metformin: A Potential Approach to Mitigate Testicular Dysfunction in Type 2 Diabetes Mellitus

Odetayo,

Abdulrahim,

Yusuf

et al. 2024

Reprod. Sci.

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High Prevalence of Lipid Disorders in Type 1 Diabetes—Time for Treatment?

Cited by 3 publications

References 7 publications

Influence of Rutin and its Combination with Metformin on Vascular Functions in Type 1 Diabetes

Influence of Rutin and its Combination with Metformin on Vascular Functions in Type 1 Diabetes

Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes

Combination Therapy with Vitamin D and Metformin: A Potential Approach to Mitigate Testicular Dysfunction in Type 2 Diabetes Mellitus

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