High Prevalence of Metabolic Syndrome among Young Women with Nonfatal Myocardial Infarction

Amowitz, Lynn L.; Ridker, Paul M.; Rifai, N; Loughrey, Clodagh; Komaroff, Anthony L.

doi:10.1089/154099904322966146

Cited by 14 publications

(7 citation statements)

References 65 publications

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“…With our study we infer that hypertension and fasting hyperglycemia are the most prevalent components of metabolic syndrome in patients of acute coronary syndrome low HDL level was the least frequent one this was in similarity of studies done by Amowitz et al 9 Tenerz A, et al 11 and Zeller M, et al 2 Metabolic syndrome is more common in patients having fasting hyperglycemia. Impaired glucose tolerance is one of the commonest components of metabolic syndrome in patients with coronary artery disease.…”

Section: Discussionsupporting

confidence: 88%

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Syndrome X in Acute Coronary Syndrome Patients - A Tertiary Care Center Study

Malhotra¹,

Shukla²,

Prabhakar³

2015

jemds

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Metabolic Syndrome (MS) or insulin resistance syndrome is commonly defined as a group of risk factors or abnormalities associated with insulin resistance that markedly increased risk for both coronary heart disease and diabetes. Cardiovascular disease and all-cause mortality, even in the absence of baseline CVD and diabetes. Early identification, treatment and prevention of the metabolic syndrome present a major challenge for health care professionals facing an epidemic of overweight and sedentary lifestyle. AIMS AND OBJECTIVESTo study the prevalence of metabolic syndrome in pts. with Acute Coronary Syndrome (ACS) and its effect on hospital outcomes. MATERIALS AND METHODSObservational study in 55 cases (28 cases and 27 controls) was conducted in Dr. BRAMH, Raipur and each patient was assessed with detailed clinical history and was also assessed for parameters of MS. The cases and controls were also followed up during their hospital stay for the presence of or development of heart failure, arrhythmias, shock and death. Chi square and 't' test were used to analyse obtained data. RESULTS AND CONCLUSIONSIn the present study sex ratio amongst the cases was (M:F) 1.15:1 and 2.6:1 in controls. Maximum patients were between the ages of 50-60. Non-ST elevation MI was more common in patients with metabolic syndrome and they presented late to the hospital for treatment. Hypertension and fasting hyperglycemia are the most prevalent components of metabolic syndrome in patients of acute coronary syndrome. Our Study also suggests that hypertriglyceridemia is the most common lipid abnormality in patients of acute coronary syndrome. An increase in the incidence of heart failure was observed in patients with metabolic syndrome Cardiogenic shock is seen with increased frequency in patients with metabolic syndrome. Case fatalities were seen with equal frequency in both the groups, hence metabolic syndrome is not associated with increased case fatality while ventricular arrhythmias have equal incidence in both the groups.

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Section: Discussionsupporting

confidence: 88%

“…As in previous studies by Zeller M, et al 2 and Amowitz LL, et al 9 in our study, out of 55 patients 28 patients (51%) had metabolic syndrome while the rest 21 patients (49%) did not have Metabolic Syndrome.…”

Section: Discussionsupporting

confidence: 86%

Syndrome X in Acute Coronary Syndrome Patients - A Tertiary Care Center Study

Malhotra¹,

Shukla²,

Prabhakar³

2015

jemds

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“…The utility of the metabolic syndrome concept for risk stratification in the young non-pregnant population [29] and the observed similarities between CVD and pre-eclampsia suggest its potential usefulness in the pregnant population. This association between pre-eclampsia and metabolic syndrome is stronger than the association with CHTN or lipids alone suggesting an added benefit to the aggregate syndrome concept over individual risk factors alone.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the association between all components of the metabolic syndrome and pre-eclampsia

Srinivas

Sammel

Bastek

et al. 2009

The Journal of Maternal-Fetal & Neonatal Medicine

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Metabolic syndrome and hs-CRP are associated with pre-eclampsia. Investigation is crucial to determine if these abnormal lipid and inflammatory pathways observed in women with pre-eclampsia are present pre-pregnancy or develop as a result of the disease process of pre-eclampsia. Further investigation is also warranted to determine whether these abnormalities persist post-pregnancy and if so, their contribution to long-term cardiovascular disease.

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“…13 They found that when compared with female controls matched for age, ethnicity, and smoking, the cases were more likely to have insulin resistance, obesity, dyslipidemia, and hypertension. Interestingly, there was no statistically significant difference in the levels of inflammatory and thrombotic biomarkers; however, the study may have been underpowered to accurately assess these associations.…”

Section: Background and Definitionmentioning

confidence: 99%

The Metabolic Syndrome in Women

Schneider¹,

Tompkins²,

Blumenthal³

et al. 2006

Cardiology in Review

102

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The metabolic syndrome, an increasingly prevalent disorder, is known to significantly enhance the risk of developing cardiovascular disease and diabetes. The syndrome is defined by a constellation of cardiac risk factors that include obesity, atherogenic dyslipidemia, hypertension, and insulin resistance. There are several unique features of the metabolic syndrome in women. An insulin-resistant state associated with both polycystic ovarian syndrome and increased abdominal fat may contribute to the development of the metabolic syndrome and increase cardiovascular risk when present. Menopause heralds a decline in circulating estrogen levels, which may increase cardiovascular risk through effects on adiposity, lipid metabolism, and prothrombotic state. The key elements involved in managing the metabolic syndrome are dietary and lifestyle modification. Appropriate treatment may also include managing individual cardiac risk factors with the use of antihypertensive and lipid-modifying agents among others.

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High Prevalence of Metabolic Syndrome among Young Women with Nonfatal Myocardial Infarction

Cited by 14 publications

References 65 publications

Syndrome X in Acute Coronary Syndrome Patients - A Tertiary Care Center Study

Syndrome X in Acute Coronary Syndrome Patients - A Tertiary Care Center Study

Evaluating the association between all components of the metabolic syndrome and pre-eclampsia

The Metabolic Syndrome in Women

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