High Prevalence of Osteoporosis and Morphometric Vertebral Fractures in Indian Males Aged 60 Years and Above: Should Age for Screening Be Lowered?

Bhat, K. M.; Kakaji, Manisha; Awasthi, Ashish; Shukla, Manoj Kumar; Dubey, Manoj Kumar; Srivastava, Rajesh K.; Singh, Uttam; Gupta, Sushil K.

doi:10.1016/j.jocd.2016.10.003

Cited by 10 publications

(6 citation statements)

References 31 publications

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“…Sundh et al emphasized that serum vitamin D is associated with higher cortical porosity in elderly men (30). Other studies also revealed the importance of vitamin D deficiency in male osteoporosis (12,15,19,31). The provinces where our study was performed are disadvantaged areas in terms of climate characteristics and insufficient sun exposure, when evaluated with regard to vitamin D synthesis.…”

Section: Resultsmentioning

confidence: 71%

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Hip Fracture Surgery in Patients Older than 90 Years: Evaluation of Factors that Affect 30-Day Mortality in a Particularly Risky Group

Daşar¹

2018

tjgeri

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Introduction: Osteoporosis in men is often underdiagnosed and neglected compared to postmenopausal women. Major risk factors should be determined to prevent this disease, which has potential risk of mortality and morbidity for elder men. This study's purpose was to determine the risk factors for osteoporosis and osteopenia in male patients aged >60 years.Materials and Method: Between January 2015 and June 2017, male patients aged >60 years admitted to our centers who underwent dual energy x-ray absorptiometry (DXA) were included in this retrospective study. Patients' age, body mass index, site of residence (village/ city), smoking status, and systemic diseases were examined through our records. Patients were divided into control, osteopenia, and osteoporosis groups according to DXA measurements. Serum vitamin D measurements also were evaluated. Multivariate analysis was performed to determine major risk factors for osteoporosis and osteopenia.Results: Compared with the control group, patients in the group categorized as having osteoporosis or osteopenia had a significantly lower body mass index and more commonly resided in the city (p<0.001 and p<0.005, respectively). Serum vitamin D levels were significantly lower in the osteoporosis and osteopenia groups than in the control group (p=0.001). According to multivariate analysis, insufficient or deficient serum vitamin D levels were determined to be a major risk factor for osteoporosis and osteopenia (p=0.001).Conclusion: According to our results, men aged >60 years with deficient serum vitamin D levels (<20 ng/mL) were six times more likely to have osteopenia and 80 times more likely to have osteoporosis.Keywords: Osteoporosis; Bone diseases, Metabolic; Bone density; Risk factors; Vitamin D Giriş: Erkeklerde osteoporoz postmenopozal kadınlara kıyasla çoğunlukla az tanı alır ve ihmal edilir. Yaşlı erkeklerde potansiyel mortalite ve morbidite riski taşıyan bu hastalığı önlemek için başlıca risk faktörleri belirlenmelidir. Bu çalışmanın amacı, 60 yaş üzerindeki erkek hastalarda osteoporoz ve osteopeni için risk faktörlerini belirlemektir.Gereç ve Yöntem: Ocak 2015-Haziran 2017 tarihleri arasında merkezlerimize başvuran ve Dual Enerji X-ray Absorptiometri (DXA) ölçümleri yapılan 60 yaş üzeri erkek hastalar bu retrospektif çalışmaya dahil edildi. Hastaların yaşı, beden kütle indeksi (BKİ), yerleşim yeri (köy-şehir), sigara içme durumu ve sistemik hastalıkları kayıtlarımızdan incelendi. Hastalar DXA ölçümlerine göre kontrol, osteopeni ve osteoporoz olarak 3 gruba ayrıldı. Hastaların serum vitamin D ölçümleri de değerlendirildi. Osteoporoz ve osteopeni için temel risk faktörlerini belirlemek için çok değişkenli analiz uygulandı.Bulgular: Kontrol grubuyla karşılaştırıldığında, osteoporoz veya osteopeni grubundaki hastalarda VKİ anlamlı derecede düşüktü ve bunlar daha çok şehirde yerleşikti (sırasıyla p<0.001 ve 0.005). Serum vitamin D seviyeleri osteoporoz ve osteopeni gruplarında kontrol grubuna göre anlamlı düşüktü (p=0.001). Çok değişkenli analize göre, yetersiz veya ...

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Section: Resultsmentioning

confidence: 71%

“…Dual energy X-ray absorbtiometry (DXA) is recommended for osteoporosis in men aged 70 years and older but supportive data is limited (12,13). Male osteoporosis is becoming an increasingly common condition with subsequent mortality and mortality (14).…”

Section: Introductionmentioning

confidence: 99%

Hip Fracture Surgery in Patients Older than 90 Years: Evaluation of Factors that Affect 30-Day Mortality in a Particularly Risky Group

Daşar¹

2018

tjgeri

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“…In a prospective study conducted in Denmark, 585 males aged 60–74 years in the general population were referred to assess BMD, of which the prevalence of OP diagnosed by BMD increased from 10.2 to 14.8 % when the vertebral fracture assessment (VFA) was added to the classification [ 25 ]. Another study focused on Danish females also reported an increase in the number of patients with OP by 9.79 % when VFA and BMD were applied simultaneously [ 26 ]. A survey from northern India showed that the prevalence of VF in healthy community-dwelling men was 24.5 % in the 60–70 year age group and 38.4 % in the 71–80 year age group [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

High prevalence of osteoporosis in patients undergoing spine surgery in China

Zhao

Wen

et al. 2021

BMC Geriatr

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Background With the increase in life expectancy, a large number of patients with osteoporosis (OP) are undergoing spine surgery, which may adversely affect the surgical success rate. The prevalence of OP varies in different regions, and no data are available that represent the prevalence of OP among Chinese patients over 50 years of age who are undergoing spine surgery. It was the first multicenter study to assess OP in these patients. Aiming to obtain comprehensive data, this study combined bone mineral density (BMD) measurements and visual radiography assessment (VRA) to analyze the prevalence of OP in patients aged > 50 years who underwent spine surgery. Methods Data from 1,856 patients aged over 50 years undergoing spine surgery who resided in northern, central, and southern China were reviewed between 2018 and 2019. Based on the perioperative BMD and X-ray data, we calculated the prevalence of OP in this special population according to sex, age, and spine degenerative disease. Results A total of 1,245 patients (678 females and 567 males) were included in the study. The prevalence of OP diagnosed by BMD was 52.8 % in females and 18.7 % in males. When we combined with BMD and VRA, the prevalence of OP increased from 52.8 to 65.9 % in females and from 18.7 to 40.6 % in males. Although OP was more severe in females than in males, a significant difference in the rate of vertebral fracture (VF) was not observed between females and males with a normal BMD and osteopenia (females vs. males: aged 50–59 years, P = 0.977; 60–69 years, P = 0.302; >70 years, P = 0.172). Similarly, no significant difference in the vertebral fracture rate was observed within different age groups of patients with a normal BMD and osteopenia (females: P = 0.210; males, P = 0.895). The incidence of OP in patients with degenerative scoliosis was higher than that in the remaining patients (females: 63.6 % vs. 42.4 %, P = 0.018; males: 38.9 % vs. 13.8 %, P = 0.004). Conclusions A high prevalence of OP was identified in patients aged > 50 years undergoing spine surgery, especially in patients whose primary diagnosis was degenerative scoliosis. BMD and VRA evaluations should be included in the clinical routine for these patients prior to surgery.

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“…However, a slightly higher prevalence of morphometric VFs has been reported in men (18.8%) compared with women (17.1%) in India, 6 and a recent study reported a prevalence of 29.5% in Indian men. 27 In the latter study, the use of lateral vertebral assessment on DXA rather than lateral radiographs may have overestimated VF. Alternatively, Indian men may be at higher risk of VFs, which was not seen in our study.…”

Section: Discussionmentioning

confidence: 81%

Prevalence and clinical risk factors for morphometric vertebral fractures in older subjects in KwaZulu-Natal

Esaadi

Paruk

Cassim

2021

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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There are limited data on vertebral fractures (VFs) in South Africa (SA). Therefore a study was undertaken to compare the demographic profile, clinical risk factors and bone mineral density (BMD) in subjects aged 60 years and over with and without morphometric VFs. Patients and methods: In a descriptive case-controlled study, demographic data, clinical risk factors (CRF) and BMD were collected. Morphometric VFs were identified using the semi-quantitative Genant method. Descriptive analysis was undertaken using Student's t-test, the Mann-Whitney U-test and the chi-square test. Results: In the 197 subjects enrolled, the median age was 72.0 years (IQR 67.0-78.5 years) and morphometric VFs were identified in 41 subjects (20.8%). The prevalence of VFs increased with age, and while more common in women compared with men (23.8% vs. 13.0%), this was not significant (p 0.095). There was no difference in the prevalence of VFs between African and Indian subjects (23.4% vs. 17.4%; p 0.240), nor CRFs between subjects with and without VFs. Subjects with a VF had a significantly lower BMD at the spine (p = 0.020), but not at the neck of femur and total hip. Conclusion: This study highlights the need for adequate screening and management protocols for osteoporosis in all ethnic groups in SA.

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High Prevalence of Osteoporosis and Morphometric Vertebral Fractures in Indian Males Aged 60 Years and Above: Should Age for Screening Be Lowered?

Cited by 10 publications

References 31 publications

Hip Fracture Surgery in Patients Older than 90 Years: Evaluation of Factors that Affect 30-Day Mortality in a Particularly Risky Group

Hip Fracture Surgery in Patients Older than 90 Years: Evaluation of Factors that Affect 30-Day Mortality in a Particularly Risky Group

High prevalence of osteoporosis in patients undergoing spine surgery in China

Prevalence and clinical risk factors for morphometric vertebral fractures in older subjects in KwaZulu-Natal

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