High prevalence of subacute thyroiditis during summer season in Italy

Martino, Enio; Buratti, Laura; Bartalena, Luigi; Mariotti, Stefano; C, Cupini; Aghini-Lombardi, F.; Pinchera, Aldo

doi:10.1007/bf03348138

Cited by 96 publications

(68 citation statements)

References 11 publications

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“…[5][6][7] It is a self limited disease thought to represent the response of the thyroid to systemic viral infection. [1][2][3][4] Clinically, the patients present with pain in the neck associated with tenderness of the gland, accompanied by malaise, weakness, fever, and an elevated ESR. [5][6][7] Depending on the phase of the disease, patients may be hyperthyroid, hypothyroid, or euthyroid.…”

Section: Discussionmentioning

confidence: 99%

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Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules

Shabb¹,

Salti²

2005

Diagn. Cytopathol.

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Subacute thyroiditis (SAT) is usually diagnosed clinically without the need for fine-needle aspiration. The cytologic literature on this condition is therefore rare. We report on 14 cases of SAT presenting with thyroid nodules. The majority of patients were women with a mean age of 46 yr. All had pain/tenderness in the thyroid area accompanied by fever or an elevated ESR. The salient cytologic features included cellular smears; multinucleated giant cells in 100% of cases, some ingesting colloid or neutrophils; fibrous fragments with enmeshed inflammatory cells were a constant feature; follicular cells were scant to absent in most cases. Granulomas were rare. Colloid, when present was thick, with central cracks and frayed edges. One case was suspicious for malignancy. We conclude that the cytologic features of SAT are predictable, particularly, in the appropriate clinical setting. FNA is also helpful in ruling out concomitant neoplastic conditions.

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Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] It typically presents in middle aged women who complain of pain and tenderness in the area of the gland, malaise, and fever. The erythrocyte sedimentation rate (ESR) is usually elevated.…”

mentioning

confidence: 99%

Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules

Shabb¹,

Salti²

2005

Diagn. Cytopathol.

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“…But direct proof has yet to be found as most attempts to isolate the viruses or viral inclusion bodies in thyroid tissue of patients have resulted in failure [5,6]. Seasonal epidemics of subacute thyroiditis have been reported, and some enterovirus infections are suggested to be the cause of epidemics occurring in summer [7]. In our cases, we could not identify the viruses, but we think that the virus that infected the first twin might be different from the virus that infected the second twin because their symptoms developed in the spring of 1993 and the summer of 1995, respectively and because they were living in different places.…”

Section: Discussionmentioning

confidence: 99%

Subacute Thyroiditis Developed in Identical Twins Two Years Apart

et al. 2005

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Abstract.A 34-year-old woman was referred to our hospital complaining of sore throat and arthralgia. She had low-grade fever, tachycardia, and goiter with tenderness. Laboratory data revealed thyrotoxicosis and tests for acute inflammatory markers were positive. Thyroidal radioactive iodine uptake was below normal. Ultrasonography of thyroid revealed mild thyroid enlargement and hypoechogenic areas consistent with tenderness. Subacute thyroiditis was diagnosed and prednisone was administered. Two years later, her identical twin sister, who lives separately, was referred to our hospital because of neck pain, low-grade fever, and palpitation. She exhibited the same clinical picture as her twin sister, and was also diagnosed as having subacute thyroiditis. Although the cause of subacute thyroiditis remains unclear, viral infection has been implicated in the onset of subacute thyroiditis in genetically predisposed individuals. We could not identify the viruses, but heterozygotes for HLA-B35, which has been reported to be linked with subacute thyroiditis, were found in the twins. This supports the suspicion that genetic factors, including this HLA haplotype, play a critical role in the onset of subacute thyroiditis.

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“…[5][6][17][18][19][20] The pathogenesis is unknown, but several viruses have been incriminated. [21][22][23] Currently, it is believed that SGT is not an autoimmune disorder. 5 In this series, a viral prodrome was recorded in 12 cases (33.33%).…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration of subacute granulomatous thyroiditis (De Quervain's thyroiditis): A clinico-cytologic review of 36 cases

García‐Solano

Bascuñana²,

Pérez³

et al. 1997

Diagn. Cytopathol.

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Although subacute granulomatous thyroiditis (SGT) is usually diagnosed clinically, there are other thyroid conditions that must be ruled out. This task is achieved by means of fine‐needle aspiration (FNA). In retrospect, the clinical and cytologic findings seen in 36 SGT cases are reassessed with a view to deciding which findings are most reliable for reaching a confident cytologic diagnosis. These are: the simultaneous presence in the same aspirate of the following cells: 1) follicular cells with intravacuolar granules and/or plump transformed follicular cells; 2) epithelioid granulomas; 3) multinucleated giant cells; 4) an acute and chronic inflammatory dirty background; 5) the absence of the following cells: fire‐flare cells, hypertrophic follicular cells, oncocytic cells, and transformed lymphocytes. The absence of one or more of these requirements does not exclude SGT but does increase the number of thyroid conditions that come into the differential diagnosis. In these cases, it is essential to review clinical data carefully and to submit the patient to a close clinical and FNA follow‐up. Diagn. Cytopathol. 16:214–220, 1997. © 1997 Wiley‐Liss, Inc.

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High prevalence of subacute thyroiditis during summer season in Italy

Cited by 96 publications

References 11 publications

Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules

Subacute thyroiditis: Fine-needle aspiration cytology of 14 cases presenting with thyroid nodules

Subacute Thyroiditis Developed in Identical Twins Two Years Apart

Fine-needle aspiration of subacute granulomatous thyroiditis (De Quervain's thyroiditis): A clinico-cytologic review of 36 cases

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