High prevalence of transfusion‐transmitted virus among patients with non‐B, non‐C hepatocellular carcinoma

Nakagawa, Naoki; Ikoma, Jiro; Ishihara, Takeshi; Yasui, Noriko Imafuji; Fujita, Naoki; Iwasa, Motoh; Kaito, Masahiko; Watanabe, Shozo; Adachi, Yukihiko

doi:10.1002/(sici)1097-0142(19991015)86:8<1437::aid-cncr8>3.3.co;2-9

Cited by 5 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, retrospective analyses of patients treated with alpha interferon with or without ribavirin for underlying HCV infection have shown that therapy may result in a generally transient disappearance of detectable TTV from blood, especially if baseline TTV viremia is low, but that this is not accompanied by modulation of ALT levels unless HCV is also cleared (4,8,16,48). In addition, attempts to link TTV to hepatocellular carcinoma in patients positive or negative for HBV and HCV have given inconsistent results (107,132,156,184). Undoubtedly, the above observations rule out the notion that clinically evident liver disease is a frequent consequence of TTV infection.…”

Section: Clinical Significancementioning

confidence: 99%

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

et al. 2001

View full text Add to dashboard Cite

TT virus (TTV) was first described in 1997 by representational difference analysis of sera from non-A to non-G posttransfusion hepatitis patients and hence intensively investigated as a possible addition to the list of hepatitis-inducing viruses. The TTV genome is a covalently closed single-stranded DNA of approximately 3.8 kb with a number of characteristics typical of animal circoviruses, especially the chicken anemia virus. TTV is genetically highly heterogeneous, which has led investigators to group isolates into numerous genotypes and subtypes and has limited the sensitivity of many PCR assays used for virus detection. The most remarkable feature of TTV is the extraordinarily high prevalence of chronic viremia in apparently healthy people, up to nearly 100% in some countries. The original hypothesis that it might be an important cause of cryptogenic hepatitis has not been borne out, although the possibility that it may produce liver damage under specific circumstances has not been excluded. The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus

show abstract

Section: Clinical Significancementioning

confidence: 99%

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Numerous investigations also revealed that the presence of TTV‐DNA was not associated with liver injury, 17,22 acute fulminant and non‐fulminant hepatitis, 21 or hepatocellular carcinoma 24 . In contrast, some other reports showed that TTV was suggested to be associated with elevated ALT levels, 1,2 , 25,26 and may play a role in the development of chronic liver diseases of unknown etiology 1,27 or even hepatocellular carcinoma 28 . One of the possible explanations as to why the difference existed regarding the pathogenesis between studies may be that there was a difference in pathogenesis that depended on the TTV genotypes.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and distribution of genotypes of TT virus infection in a hepatitis C virus‐hyperendemic township of a hepatitis B virus‐endemic country (Taiwan)

Dai

Hou

et al. 2002

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Chronic infection with HGV may play a role in the development of HCC in non‐Asians in Los Angeles 6 . A high prevalence of TTV infection has been detected among patients with non‐B, non‐C HCC, suggesting a potential association between TTV infection and HCC 7 . The risk of dietary iron overload was 4.1 for HCC in black African people 8 .…”

Section: Aetiology Prevention and Hepatocarcinogenesismentioning

confidence: 99%

Hepatocellular carcinoma

Tang

2000

J of Gastro and Hepatol

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) has ranked second in cancer mortality in China since the 1990s and is increasing in frequency among males in many countries. Hepatitis B and C viruses, aflatoxin and algal toxin in the contaminated drinking water remain major aetiological factors and hepatitis G virus and transfusion-transmitted virus can not be excluded. A prospective randomized control trial screening for HCC in a high-risk population using alpha fetoprotein (AFP) and ultrasonography has demonstrated a decrease in HCC mortality. Rapidly progressing medical imaging has continuously contributed to the improving treatment results. Surgical resection still plays a major role in influencing prognosis of HCC. Studies on recurrence and metastasis after curative resection have become a key issue for further improvement of the surgical outcome. Regional cancer therapies are progressing rapidly, based on the advances in early diagnosis. The advantages and disadvantages of these are noted. Multimodality combination and sequential treatment has been accepted as an important approach for unresectable HCC and cytoreduction and sequential resection have attracted attention. Conformal radiotherapy has shown important potential for HCC treatment. Intra-arterial chemotherapy has been repeatedly proved effective; however, systemic chemotherapy for HCC remains disappointing. The effects of tamoxifen are questionable, whereas alpha-interferon has been shown to have significant potential, particularly in prevention of recurrence. All of these treatments have resulted in continuing improvement of HCC prognosis in some centres.

show abstract

High prevalence of transfusion‐transmitted virus among patients with non‐B, non‐C hepatocellular carcinoma

Abstract: This study showed that TTV DNA is frequently detected in the serum of patients with non-B, non-C hepatocellular carcinoma. This result suggests a potential pathogenetic association between hepatocellular carcinoma and TTV infection.

Cited by 5 publications

References 0 publications

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

Clinical characteristics and distribution of genotypes of TT virus infection in a hepatitis C virus‐hyperendemic township of a hepatitis B virus‐endemic country (Taiwan)

Hepatocellular carcinoma

Contact Info

Product

Resources

About