High prevalence of vitiligo in lepromatous leprosy

Boisseau‐Garsaud, Anne‐Marie; Vezon, G.; Helenon, R.; Garsaud, Philippe; Saint-Cyr, I.; Quist, D.

doi:10.1046/j.1365-4362.2000.00093.x

Cited by 13 publications

(7 citation statements)

References 5 publications

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“…But, we might first question whether microbial changes have been associated with melanoma or vitiligo (Gudjonsson et al., 2020). The association between microbes and progressive depigmentation stands out when we realize that vitiligo is approximately 10‐fold more prevalent among lepromatous leprosy patients (Boisseau‐Garsaud et al., 2000). This relationship would make vitiligo seem contagious, explaining why vitiligo can be so stigmatizing in locations where leprosy exists (Pahwa et al., 2013).…”

Section: Environmental Insults Impact Microbial Homeostasismentioning

confidence: 99%

Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation

Poole

2021

Pigment Cell Melanoma Res

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Melanocytes are static, minimally proliferative cells. This leaves them vulnerable in vitiligo. Yet upon malignant transformation, they form vicious tumors. This profound switch in physiology is accompanied by genetic change and is driven by environmental factors. If UV exposure in younger years supports malignant transformation and melanoma formation, it can likewise impart mutations on melanocytes that reduce their viability, to initiate vitiligo. A wide variety of microbes can influence these diametrically opposed outcomes before either disease takes hold. These microbes are vehicles of change that we are only beginning to study. Once a genetic modification occurs, there is a wide variety of immune cells ready to respond. Though it does not act alone, the T cell is among the most decisive responders in this process. The same biochemical process that offered the skin protection by producing melanin can become an Achilles heel for the cell when the T cells target melanosomal enzymes or, on occasion, neoantigens. T cells are precise, determined, and consequential when they strike. Here, we probe the relationship between the microbiome and its metabolites, epithelial integrity, and the activation of T cells that target benign and malignant melanocytes in vitiligo and melanoma.

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Section: Environmental Insults Impact Microbial Homeostasismentioning

confidence: 99%

Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation

Poole

2021

Pigment Cell Melanoma Res

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“…Corcos 82 studied how the depigmentation spread, and concluded that it was not passed from one cell to another but that it is brought about by extra bacillary proliferation of a subcellular, selfreplicating agent initially carried by mycobacteria, rather than by the mycobacteria themselves. In leprosy, the lepromatous end of the spectrum is 11 times more likely to be associated with vitiligo than is tuberculoid leprosy 83 . It has been most recently demonstrated that Mycobacterium leprae alters the genetics of Schwann cells without even penetrating their nuclei and this activates genes that convert the cell into a neural crest stem cell, shielding the bacteria from destructive elements 84 .…”

Section: Leprosymentioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

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Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

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“…The study was carried out in the only reference hospital for the follow-up of leprosy patients in Martinique, a place with a highly endemic leprosy. No patient from the tuberculoid pole had vitiligo 10 .…”

Section: Introductionmentioning

confidence: 96%

Vitiligo after borderline lepromatous leprosy: common immunological implications

Sequeira,

Cupertino,

Cunha

et al. 2024

PJDV

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Objective:The objective of this study is to demonstrate the occurrence of vitiligo after multibacillary (MB) leprosy. Methods: This study was a review of medical registry of patients followed at the leprosy and vitiligo outpatient clinics at a reference university hospital in the city of Rio de Janeiro. Results: Five cases of vitiligo were identified in patients from the MB leprosy, all reactional (before, during, and after treatment), with lesions appearing on average 10 years after the diagnosis of leprosy. Conclusion: There are few reports on the association between the two diseases in the world literature. However, all existing studies to date have shown the predominance of vitiligo in the MB pole. Humoral, innate, and adaptive immunity play an important role in the pathophysiology of MB pole, leprosy reactions, and vitiligo, but they have not yet been fully elucidated. Genome-wide association studies have highlighted several susceptibility genes that also require better understanding.

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High prevalence of vitiligo in lepromatous leprosy

Abstract: Our data confirmed that the association of vitiligo and leprosy was not fortuitous. The physiopathology leading to this high rate of vitiligo in lepromatous leprosy is unclear, despite the fact that autoimmunity plays a major role in both diseases.

Cited by 13 publications

References 5 publications

Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation

Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Vitiligo after borderline lepromatous leprosy: common immunological implications

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