High-protein diet and omega-3 fatty acids improve redox status in olanzapine-treated rats

Mitrović, Miroslav; Turnic, Tamara Nikolic; Živković, Vladimir; Pavic, Z.; Vranic, Aleksandra; Srejović, Ivan; Sretenovic, Jasmina; Bolevich, Sergey; Jakovljević, Vladimir

doi:10.1007/s11010-020-03718-6

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…The possibilities of controlling these negative effects of drugs while maintaining the positive therapeutic effects are very interesting. Treatment with olanzapine (an antipsychotic drug) has been associated with increased release of prooxidants and decreased activity of antioxidant markers (54). The addition of whey protein to the diet (alone or in combination with omega fatty acids) has managed to achieve partial positive control over the negative impact of measurable free radicals (54).…”

Section: Whey Proteins and Their Protective Role During Oxidative Stressmentioning

confidence: 99%

“…Treatment with olanzapine (an antipsychotic drug) has been associated with increased release of prooxidants and decreased activity of antioxidant markers (54). The addition of whey protein to the diet (alone or in combination with omega fatty acids) has managed to achieve partial positive control over the negative impact of measurable free radicals (54). Interestingly, these effects were better during the separate administration of whey protein from omega fatty acids, which indicates that at the level of dietary supplements there is the possibility of interactions and competition at the level of antioxidant enzymes, especially when given together with drugs (54).…”

Section: Whey Proteins and Their Protective Role During Oxidative Stressmentioning

confidence: 99%

“…The addition of whey protein to the diet (alone or in combination with omega fatty acids) has managed to achieve partial positive control over the negative impact of measurable free radicals (54). Interestingly, these effects were better during the separate administration of whey protein from omega fatty acids, which indicates that at the level of dietary supplements there is the possibility of interactions and competition at the level of antioxidant enzymes, especially when given together with drugs (54). These forms of research are potentially interesting because they can examine the possibilities of beneficial synergism and antioxidant protection of the calf, during the application of many drugs.…”

Section: Whey Proteins and Their Protective Role During Oxidative Stressmentioning

confidence: 99%

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Whey proteins: Facts and possibilities in modern medicine

Mitrović,

Mitrovič,

Tasič

et al. 2023

Medicinski časopis

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The values of whey as a healthy and therapeutically useful drink are well known, and in folk medicine it has often been attributed miraculous powers and possibilities. This is nothing new, bearing in mind that in 460 BC, the father of medicine Hippocrates emphasized the value of whey in the treatment of tuberculosis, jaundice, diseases of the liver and digestive system, skin diseases and many other diseases. Whey is obtained during milk processing and cheese production, where it is present in almost 90% of the total mass. The composition of whey is specific. Water makes up to 93% of the composition, the rest consists of sugars and minerals, B vitamins, as well as a great wealth of probiotic bacteria. Whey is the largest source of essential amino acids compared to plant or animal sources. The concentration of amino acids in whey is 43% compared to oats (21%), wheat husk (21%) and wheat (22%), milk 39%, casein 34% and eggs 32%) or meat proteins (38%). Whey proteins contain almost 50% of essential amino acids and about 26% of branched-chain amino acids. Their composition is similar to the amino acid composition of human muscles, which allows their faster absorption than other sources of protein. The share of free amino acids in whey is 4 to 10 times higher than in milk. They have a significant effect on protein synthesis and a very strong anabolic effect in the body. Whey amino acids stimulate skeletal muscle regeneration, reduce fatigue, increase synthesis, and reduce muscle protein breakdown. Whey proteins increase the levels of antioxidant enzymes, especially glutathione and catalase. Positive effect on the reduction of the levels of TBARS (thiobarbituric acid reactive substance) is an important indicator of the decreasing process of lipid peroxidation. Reduction of oxidative stress process in the liver has positive consequences on inflammation and the content of lipids in the liver tissue and atherosclerosis process. Recent research indicates a positive effect on glucose metabolism, improving insulin sensitivity and preventing the development of fatty liver syndrome and type 2 diabetes. It has a positive effect on weight control, so whey proteins are integral parts of healthy medical diets, sport drinks, with approved efficacy in obesity treatments. Essential amino acids also act as neurogenic active substances, and they are also known as precursors of biogenic amines and neurotransmitters, so it is logical that there is a growing interest in researching their potential in psychiatry.

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Section: Whey Proteins and Their Protective Role During Oxidative Stressmentioning

confidence: 99%

Section: Whey Proteins and Their Protective Role During Oxidative Stressmentioning

confidence: 99%

Section: Whey Proteins and Their Protective Role During Oxidative Stressmentioning

confidence: 99%

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Whey proteins: Facts and possibilities in modern medicine

Mitrović,

Mitrovič,

Tasič

et al. 2023

Medicinski časopis

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Fatty Acid Profile and Genetic Variants of Proteins Involved in Fatty Acid Metabolism Could Be Considered as Disease Predictor

et al. 2023

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Circulating fatty acids (FA) have an endogenous or exogenous origin and are metabolized under the effect of many enzymes. They play crucial roles in many mechanisms: cell signaling, modulation of gene expression, etc., which leads to the hypothesis that their perturbation could be the cause of disease development. FA in erythrocytes and plasma rather than dietary FA could be used as a biomarker for many diseases. Cardiovascular disease was associated with elevated trans FA and decreased DHA and EPA. Increased arachidonic acid and decreased Docosahexaenoic Acids (DHA) were associated with Alzheimer’s disease. Low Arachidonic acid and DHA are associated with neonatal morbidities and mortality. Decreased saturated fatty acids (SFA), increased monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) (C18:2 n-6 and C20:3 n-6) are associated with cancer. Additionally, genetic polymorphisms in genes coding for enzymes implicated in FA metabolism are associated with disease development. FA desaturase (FADS1 and FADS2) polymorphisms are associated with Alzheimer’s disease, Acute Coronary Syndrome, Autism spectrum disorder and obesity. Polymorphisms in FA elongase (ELOVL2) are associated with Alzheimer’s disease, Autism spectrum disorder and obesity. FA-binding protein polymorphism is associated with dyslipidemia, type 2 diabetes, metabolic syndrome, obesity, hypertension, non-alcoholic fatty liver disease, peripheral atherosclerosis combined with type 2 diabetes and polycystic ovary syndrome. Acetyl-coenzyme A carboxylase polymorphisms are associated with diabetes, obesity and diabetic nephropathy. FA profile and genetic variants of proteins implicated in FA metabolism could be considered as disease biomarkers and may help with the prevention and management of diseases.

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High-protein diet and omega-3 fatty acids improve redox status in olanzapine-treated rats

Cited by 2 publications

References 30 publications

Whey proteins: Facts and possibilities in modern medicine

Whey proteins: Facts and possibilities in modern medicine

Fatty Acid Profile and Genetic Variants of Proteins Involved in Fatty Acid Metabolism Could Be Considered as Disease Predictor

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