High‐refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats

Niño, Oscar; Costa, Charles S. da; Torres, Karine M.; Zanol, Jordana F.; Freitas-Lima, Leandro Ceotto; Miranda-Alves, Leandro; Graceli, Jones Bernardes

doi:10.1016/j.toxlet.2020.07.002

Cited by 20 publications

(8 citation statements)

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“…In line with early puberty onset, HSD rats displayed increased cystic and atretic antral ovarian follicles. Likewise, Nino et al (37) found that a high-carbohydrate diet was able to increase the number of atretic follicles in rats. Furthermore, Roberts et al (38) have shown that animals fed a high-fat, high-sugar diet had higher frequency of cystic follicles when compared to control animals.…”

Section: Discussionmentioning

confidence: 93%

Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health

et al. 2021

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BackgroundThe metabolic syndrome (MetS) is correlated with disorders of the reproductive system, such as the polycystic ovary syndrome (PCOS). While consumption of a diet rich in carbohydrates is linked to the development of MetS, it is still unclear if this diet leads to ovarian dysfunction and PCOS.ObjectivesWe investigated the influence of a high-sucrose diet (HSD) on the ovarian milieu of Wistar rats and studied the correlation between high consumption of sugary drinks and the prevalence of PCOS in women.MethodsWistar rats were given a standard laboratory diet (CTR, 10% sucrose, n = 8) or HSD (HSD, 25% sucrose, n = 8) from postnatal day 21 to 120. Animals were evaluated weekly to calculate food intake, feed efficiency and weight gain. Both onset of puberty and estrous cycle were monitored. Metabolic serum biochemistry, organ morphometry and ovarian histology were performed upon euthanasia. In parallel, a fixed-effects multiple linear regression analysis was performed using data from Brazilian states (459 state-year observations) to test the correlation between the consumption of sugar-sweetened beverages (surrogate for HSD intake) and the prevalence of PCOS (surrogate for ovarian dysfunction).ResultsHSD animals showed increased adipose tissue accumulation, hyperglycaemia and insulin resistance when compared to CTR. Interestingly HSD rats also entered puberty earlier than CTR. Moreover, ovaries from HSD animals had an increased number of atretic antral follicles and cystic follicles, which were correlated with the hypertrophy of periovarian adipocytes. Finally, there was a positive correlation between the intake of sugary drinks and prevalence of PCOS in women of reproductive age.ConclusionsHSD ingestion leads to ovarian dysfunction in rats and could be correlated with PCOS in women, suggesting these alterations could lead to public health issues. Therefore, we reinforce the deleterious impact of HSD to the ovarian system and suggest that the reduction of added sugars intake could be beneficial to ovarian health.

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Section: Discussionmentioning

confidence: 93%

Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health

et al. 2021

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“…Lipid accumulation in the liver is associated with lipid metabolism leading to hepatic steatosis. The degree of hepatic steatosis is measured by the concentration of TC and TG contents in liver tissue [ 25 , 26 , 27 ]. By the formation of lipid droplets in the liver, the accumulation of fat globules increased in the HCD group compared with the ND group.…”

Section: Resultsmentioning

confidence: 99%

Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet

et al. 2021

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Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). First, the mice were divided into five groups (n = 6/group) as follows: normal diet, HCD, and HCD+EAT (100, 200, and 400 mg/kg/day), which were orally administered with EAT daily for 84 days. Using microcomputed tomography (micro-CT) analysis, we found that EAT inhibited not only body-weight gain, but also visceral fat and subcutaneous fat accumulation. Histological analysis confirmed that EAT decreased the size of fat tissues. EAT consistently improved various indices, including plasma levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein, high-density lipoprotein, atherogenic index, and cardiac risk factors, which are related to dyslipidemia—a major risk factor for heart disease. The contents of TC and TG, as well as the lipid droplets of HCD-induced hepatic accumulation in the liver tissue, were suppressed by EAT. Taken together, these findings suggest the possibility of developing EAT as a therapeutic agent for improving HCD-induced obesity and hyperlipidemia.

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“…Die Ernährung bei Frauen mit PCOS spielt in der Therapie eine entscheidende Rolle. Untersuchungen bei Ratten weisen auf den negativen Einfluss einer Ernährung mit hohen Anteilen raffinierter Kohlenhydrate auf den Reproduktionstrakt mit der Entwicklung PCOS-ähnlicher Veränderungen hin [58].…”

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Microbiome and metabolism in polycystic ovary syndrome (PCOS)

Heizmann

Keck

2021

Gynäkologe

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ZusammenfassungDas Syndrom der polyzystischen Ovarien (PCOS) gehört zu den häufigen Hormonstörungen bei Frauen in der fertilen Lebensphase. Die Ätiologie ist bis heute nicht bekannt, allerdings konnte in den letzten Jahren das Verständnis der pathophysiologischen Zusammenhänge deutlich verbessert werden. Neben endokrinologischen und metabolischen Aspekten findet der Zusammenhang zwischen PCOS und Darmmikrobiom zunehmende Beachtung. Es konnte gezeigt werden, dass das Darmmikrobiom von Frauen mit PCOS sich signifikant vom Mikrobiom nichtbetroffener Frauen unterscheidet. Daraus lassen sich therapeutische Konsequenzen ableiten, welche die Behandlung von PCOS-Patientinnen in Zukunft maßgeblich beeinflussen könnten.

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High‐refined carbohydrate diet leads to polycystic ovary syndrome-like features and reduced ovarian reserve in female rats

Cited by 20 publications

References 59 publications

Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health

Early Exposure to High-Sucrose Diet Leads to Deteriorated Ovarian Health

Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet

Microbiome and metabolism in polycystic ovary syndrome (PCOS)

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