High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children

Orbe-Orihuela, Yaneth Citlalli; Lagunas‐Martínez, Alfredo; Bahena-Román, Margarita; Madrid‐Marina, Vicente; Torres-Poveda, Kirvis; Flores‐Alfaro, Eugenia; Méndez-Padrón, Araceli; Díaz-Benítez, Cinthya Estefhany; Peralta‐Zaragoza, Oscar; Antúnez-Ortiz, Diana Lizzete; Cruz, Miguel; Burguete-García, Ana I.

doi:10.21149/8133

Cited by 36 publications

(36 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At the higher phylum level, Firmicutes and Cynobacteria increased in relative abundance, whereas the relative abundance of Proteobacteria decreased in AdV+ mouse lemurs. An increase in Firmicutes has been found to be associated with obesity in humans as well as in other animals 35–37 . It is interesting to observe that Firmicutes increased in AdV+ lemurs since a recent study reported AdV-induced obesity in humans and proposed microbiome dysbiosis as a potential cause 38 .…”

Section: Discussionmentioning

confidence: 99%

Adenovirus infection is associated with altered gut microbial communities in a non-human primate

Wasimuddin

Corman

Ganzhorn

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Adenovirus (AdV) infections are one of the main causes of diarrhea in young children. Enteric AdVs probably disrupt gut microbial defences, which can result in diarrhea. To understand the role of the gut microbiome in AdV-induced pathologies, we investigated the gut microbiome of a naturally AdV-infected non-human primate species, the Malagasy mouse lemur (Microcebus griseorufus), which represents an important model in understanding the evolution of diseases. We observed that AdV infection is associated with disruption of the gut microbial community composition. In AdV+ lemurs, several commensal taxa essential for a healthy gut microbiome decreased, whereas genera containing potential pathogens, such as Neisseria, increased in abundance. Microbial co-occurrence networks revealed a loss of important microbial community interactions in AdV+ lemurs and an overrepresentation of Prevotellaceae. The observation of enteric virus-associated loss of commensal bacteria and associated shifts towards pathobionts may represent the missing link for a better understanding of AdV-induced effects in humans, and also for their potential as drivers of co-infections, an area of research that has been largely neglected so far.

show abstract

Section: Discussionmentioning

confidence: 99%

Adenovirus infection is associated with altered gut microbial communities in a non-human primate

Wasimuddin

Corman

Ganzhorn

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Interestingly, HIV-infected individuals with severe periodontal disease display a higher level of SCFA in the saliva compared to healthy individuals [48]. Firmicutes abundance has also been linked to TNF-α serum concentration in young obese patients [49]. However, since our study was cross-sectional, it is also possible that changes in the oral microbiome were a consequence of detectable oral cellassociated KSHV DNA or oral KS development, which is closely linked to the immune status of the subjects.…”

Section: Discussionmentioning

confidence: 84%

Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA

et al. 2020

View full text Add to dashboard Cite

Infection by Kaposi's sarcoma-associated herpesvirus (KSHV) is necessary for the development of Kaposi's sarcoma (KS), which most often develops in HIV-infected individuals. KS frequently has oral manifestations and KSHV DNA can be detected in oral cells. Numerous types of cancer are associated with the alteration of microbiome including bacteria and virus. We hypothesize that oral bacterial microbiota affects or is affected by oral KS and the presence of oral cell-associated KSHV DNA. In this study, oral and blood specimens were collected from a cohort of HIV/KSHV-coinfected individuals all previously diagnosed with KS, and were classified as having oral KS with any oral cell-associated KSHV DNA status (O-KS, n = 9), no oral KS but with oral cell-associated KSHV DNA (O-KSHV, n = 10), or with neither oral KS nor oral cell-associated KSHV DNA (No KSHV, n = 10). We sequenced the hypervariable V1-V2 region of the 16S rRNA gene present in oral cell-associated DNA by next generation sequencing. The diversity, richness, relative abundance of operational taxonomic units (OTUs) and taxonomic composition of oral microbiota were analyzed and compared across the 3 studied groups. We found impoverishment of oral microbial diversity and enrichment of specific microbiota in O-KS individuals compared to O-KSHV or No KSHV individuals. These results suggest that HIV/KSHV coinfection and oral microbiota might impact one another and influence the development of oral KS.

show abstract

“…Metabolites secreted by Firmicutes spp. decreased the production of pro-in ammatory factors such as TNF-α, thus suppressed the occurrence of in ammation [83]. Probiotics such as Lactobacillales spp.…”

Section: Discussionmentioning

confidence: 99%

Honokiol Nanoscale Drug Delivery System Ameliorates the Cognitive Deficits in Tgcrnd8 Mice of Alzheimer’s Disease via Inhibiting Neuropathology and Modulating Gut Microbiota

Qu¹,

Li²,

Su³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Honokiol (HO) exerts neuroprotective effects in several animal models of Alzheimer’s disease (AD), but the poor dissolution hampers its bioavailability and therapeutic efficacy. A novel honokiol nanoscale drug delivery system (Nano-HO) with smaller size and excellent stability was developed in this study to improve the solubility and bioavailability of HO. Methods Male TgCRND8 mice were administered with Nano-HO or HO at the same dosage (20 mg/kg) by oral gavage daily for 17 consecutive weeks, followed by assessment of the spatial learning and memory functions with the Morris Water Maze test (MWMT). Results Nano-HO and HO could significantly improve cognitive deficits and inhibit neuroinflammation via suppressing the levels of tumor necrosis factor (TNF-α), interleukin 6 (IL-6) and IL-1β in the brain, preventing the activation of microglia (IBA-1) and astrocyte (GFAP), and reducing β-amyloid (Aβ) deposition in the cortex and hippocampus of TgCRND8 mice. In addition, Nano-HO and HO could modulate amyloid precursor protein (APP) processing and phosphorylation via suppressing β-secretase including β-site APP cleaving enzyme-1 (BACE-1) and phosphorylated APP (Thr 668), inhibiting γ-secretase including presenilin-1 (PS-1) and anterior pharynx-defective-1 (APH-1), as well as enhancing Aβ-degrading enzymes such as insulin degrading enzyme (IDE) and neprilysin (NEP). Moreover, Nano-HO remarkably inhibited tau hyperphosphorylation via decreasing the levels of p-tau (Thr 205) and p-tau (Ser 404), as well as regulating tau-related apoptosis proteins including caspase-3 and Bcl-2. Furthermore, Nano-HO and HO markedly attenuated the ratios of p-JNK/JNK and p-35/CDK5, while enhancing the ratio of p-GSK-3β (Ser9)/GSK-3β. On the other hand, Nano-HO and HO prevented the alterations on the composition of gut microbiota in TgCRND8 mice. Conclusions Nano-HO was more effective than regular HO in improving cognitive impairments in TgCRND8 mice via inhibiting Aβ deposition, tau hyperphosphorylation and neuroinflammation through suppressing the activation of JNK/CDK5/GSK-3β signaling pathway. Nano-HO was also more potently modulate the gut microbiota community to protect its stability as compared with that of regular HO. Our results amply indicated that HO with nano-sized drug delivery system has good potential for further development into therapeutic agent for AD treatment.

show abstract

High relative abundance of firmicutes and increased TNF-α levels correlate with obesity in children

Cited by 36 publications

References 37 publications

Adenovirus infection is associated with altered gut microbial communities in a non-human primate

Adenovirus infection is associated with altered gut microbial communities in a non-human primate

Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA

Honokiol Nanoscale Drug Delivery System Ameliorates the Cognitive Deficits in Tgcrnd8 Mice of Alzheimer’s Disease via Inhibiting Neuropathology and Modulating Gut Microbiota

Contact Info

Product

Resources

About