Recently, the self-modulation scheme of a weakly pre-bunched electron beam has been proposed [Yan et al., Physical Review Letters 126, 084801 (2021)], which is of great promise for highrepetition-rate seeded free-electron lasers (FELs), such as high-gain harmonic generation (HGHG). In this paper, the self-modulation scheme is systematically analyzed and optimized, and further experiments in which the self-modulator is resonant at the second harmonic of the seed laser are conducted. The three-dimensional numerical simulations show that the required seed laser intensity in the self-modulation scheme is around three orders of magnitude lower than that of the standard HGHG through the optimization of the beam size or the peak current. More importantly, by reasonably setting the initial energy modulation and the resonance of the self-modulator, a more prominent bunching factor and lase at the 30th harmonic of the seed laser can be achieved in a single-stage HGHG. Moreover, the experiment results confirm that varying the resonance conditions of the self-modulator can still amplify the laser-induced energy modulation, where coherent radiation generated even at the 12th harmonic can be observed. These results indicate that the self-modulation scheme can remarkably reduce the requirements of the seed laser system while improving the harmonic up-conversion efficiency, which paves the way for realizing high-repetition-rate and fully coherent soft x-ray FELs.