High‐resolution 7T MRI of the human hippocampus in vivo

Thomas, Bradley P.; Welch, E. Brian; Niederhauser, Blake D.; Whetsell, William O.; Anderson, Adam W.; Gore, John C.; Avison, Malcolm J.; Creasy, Jeffrey L.

doi:10.1002/jmri.21576

Cited by 118 publications

(101 citation statements)

References 16 publications

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“…For example, many of the brain's major white matter fiber bundles and distinct cortical lamination patterns have recently been visualized in vivo by observing the signal phase that is proportional to the resonance frequency in gradient-echo (GRE) MRI (1)(2)(3)(4). Despite this achievement and the potential clinical and scientific significance, however, the mechanisms underlying magnetic resonance frequency shifts remain poorly understood.…”

mentioning

confidence: 99%

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure

Lee

Shmueli²,

Fukunaga³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

249

316

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Recent advances in high-field (≥7 T) MRI have made it possible to study the fine structure of the human brain at the level of fiber bundles and cortical layers. In particular, techniques aimed at detecting MRI resonance frequency shifts originating from local variation in magnetic susceptibility and other sources have greatly improved the visualization of these structures. A recent theoretical study [He X, Yablonskiy DA (2009) Proc Natl Acad Sci USA 106:13558–13563] suggests that MRI resonance frequency may report not only on tissue composition, but also on microscopic compartmentalization of susceptibility inclusions and their orientation relative to the magnetic field. The proposed sensitivity to tissue structure may greatly expand the information available with conventional MRI techniques. To investigate this possibility, we studied postmortem tissue samples from human corpus callosum with an experimental design that allowed separation of microstructural effects from confounding macrostructural effects. The results show that MRI resonance frequency does depend on microstructural orientation. Furthermore, the spatial distribution of the resonance frequency shift suggests an origin related to anisotropic susceptibility effects rather than microscopic compartmentalization. This anisotropy, which has been shown to depend on molecular ordering, may provide valuable information about tissue molecular structure.

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mentioning

confidence: 99%

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure

Lee

Shmueli²,

Fukunaga³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

249

316

View full text Add to dashboard Cite

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“…Delineating hippocampal sublayers can be difficult without knowledge of the sublayer anatomy and signal characteristics of each component [10,22]. High-resolution MPRAGE provide better defined gray, white matter and CSF differentiation compared with conventional 2D sequence [15].…”

Section: Discussionmentioning

confidence: 99%

“…It extends in a curve, starting from the amygdala ventrally in each piriform lobe and progressing caudodorsally and then cranially over the diencephalon [8,21]. The caudal end of the hippocampal formation tapers under the splenium of the corpus callosum [22]. Dorsal to the caudal thalamus, the hippocampal formation of each cerebral hemisphere meets at the medial plane, and the fornix, the hippocampal commissure, is formed at this region [2,8].…”

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confidence: 99%

Canine Hippocampal Formation Composited into Three-Dimensional Structure Using MPRAGE

Jung

Nahm

Lee

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. This study was performed to anatomically illustrate the living canine hippocampal formation in three-dimensions (3D), and to evaluate its relationship to surrounding brain structures. Three normal beagle dogs were scanned on a MR scanner with inversion recovery segmented 3D gradient echo sequence (known as MP-RAGE: Magnetization Prepared Rapid Gradient Echo). The MRI data was manually segmented and reconstructed into a 3D model using the 3D slicer software tool. From the 3D model, the spatial relationships between hippocampal formation and surrounding structures were evaluated. With the increased spatial resolution and contrast of the MPRAGE, the canine hippocampal formation was easily depicted. The reconstructed 3D image allows easy understanding of the hippocampal contour and demonstrates the structural relationship of the hippocampal formation to surrounding structures in vivo.KEY WORDS: 3D, canine, hippocampal formation, MPRAGE.J. Vet. Med. Sci. 72 (7): [853][854][855][856][857][858][859][860] 2010 The hippocampal formation is located in the medial surface of the temporal lobe, along the floor and medial wall of the temporal horn of the lateral ventricle [1,2]. The hippocampal formation is shaped like a C [19]. It extends in a curve, starting from the amygdala ventrally in each piriform lobe and progressing caudodorsally and then cranially over the diencephalon [8,21]. The caudal end of the hippocampal formation tapers under the splenium of the corpus callosum [22]. Dorsal to the caudal thalamus, the hippocampal formation of each cerebral hemisphere meets at the medial plane, and the fornix, the hippocampal commissure, is formed at this region [2,8]. The hippocampal formation can be divided into three parts: a cranial part, or head, a middle part, or body and a caudal part, or tail [8]. It is again divided into 3 main transverse zones: the dentate gyrus; the hippocampal proper, also called the cornus ammonis (CA); and the subiculum [1,2,24].Abnormalities of the hippocampal contour and volume play important roles in several functions such as spatial response in dogs [12] [5,17]. These have been resulted in increased importance of the precise understanding of the hippocampal anatomy. These also have made three-dimensional (3D) hippocampal structure importance in medical image.MRI has been the principal method for studying structural brain change in vivo [11]. Normal MR images of canine brain has been described in previous studies [13,14]. They have only depicted the normal canine brain using a low field strength MRI scanner. In those images, description of the hippocampal formation and the perihippocampal structures were not available. It was because of their small size and ambiguity with the perihippocampal structures and low field strength having decreased signal to noise ratio [11]. There haven't been MRI studies that focused on the hippocampal formation itself. In addition, it is not easy to comprehend 3D relationship among the brain structures on MRI. Currently, the 3D canine hippocampal imag...

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“…[1][2][3] In this respect, the fluorophores emitting in the second near infrared biological window (NIR-II, 1,000-1,400 nm) is particularly advantageous over those emitting at the visible (400-650 nm) or first near-infrared (NIR-I, 650-900 nm) regions because of the greatly reduced light absorption and photon scattering together with negligible tissue autofluorescence 4,5 . As a result, NIR-II fluorescence imaging can allow deep penetration into biological tissues with excellent imaging fidelity, sensitivity and resolution.…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of β-lactoglobulin capped Ag₂S quantum dots for in vivo imaging in the second near-infrared biological window

et al. 2016

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Effective in vivo fluorescence imaging for cancer screening and diagnostics requires bright and biocompatible fluorophores whose emission can effectively penetrate biological tissues. Recent studies have confirmed that the second near-infrared window (NIR-II, 1,000-1,400 nm) is the most sensitive spectral range for in vivo imaging due to ultralow tissue absorption and autofluorescence. We report herein a facile synthesis of Ag2S QD LG T LG biodistribution and reduces in vivoQDs exhibit superior photostablity and biocompatibility, making them a promising probe for in vivo NIR-II imaging.

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High‐resolution 7T MRI of the human hippocampus in vivo

Cited by 118 publications

References 16 publications

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure

Canine Hippocampal Formation Composited into Three-Dimensional Structure Using MPRAGE

Facile synthesis of β-lactoglobulin capped Ag₂S quantum dots for in vivo imaging in the second near-infrared biological window

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High‐resolution 7T MRI of the human hippocampus in vivo

Cited by 118 publications

References 16 publications

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure

Sensitivity of MRI resonance frequency to the orientation of brain tissue microstructure

Canine Hippocampal Formation Composited into Three-Dimensional Structure Using MPRAGE

Facile synthesis of β-lactoglobulin capped Ag2S quantum dots for in vivo imaging in the second near-infrared biological window

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Facile synthesis of β-lactoglobulin capped Ag₂S quantum dots for in vivo imaging in the second near-infrared biological window