High-resolution chemical profiling and antiparasitic potential of the tropical shrub Dillenia suffruticosa

Shah, Muhammad Dawood; Tani, Kazuki; Maran, Balu Alagar Venmathi; Yong, Yoong Soon; Ching, Fui Fui; Shaleh, Sitti Raehanah Muhamad; Vairappan, Charles Santhanaraju

doi:10.1007/s12562-020-01456-8

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…Compared to our study some other plants have also been reported with antiparasitic properties such as the chromatographic fractions of the methanol extract of Dillenia suffruticosa (Dilleneacea) (known as “Simpoh ayer” in Malay) [ 22 ]. A fraction of the methanol extract of D. suffruticosa resulted in the total mortality of Z. arugamensis at a concentration of 20 mg/mL in a time limit of 31 min [ 22 ]. The active component of Piper nigrum (Piperaceae) (black pepper) has been applied against branchiuran ectoparasite Argulus spp.…”

Section: Discussionmentioning

confidence: 71%

“…officinalis and S. alopecuroides at a concentration of 40 mg/L and 120 mg/L, respectively, were applied against the ciliate parasite Ichthyophthirius multifiliis infesting goldfish for 1 h. The extract of the plants reduced the prevalence of parasites by 24.7% and 44.7%, respectively [ 27 ]. From the abovementioned different studies, it is evidently proved that the medicinal plants have the potent antiparasitic properties [ 22 , 23 , 24 , 25 , 26 , 27 ]. Compared to these plants, the chromatographic fractions of the methanol extract of our sample have shown much better activity such as fraction 3 killing all leeches in 1.92 min.…”

Section: Discussionmentioning

confidence: 99%

“…The fractions were analyzed as described previously [ 22 ], where Agilent 1290 Infinity LC system coupled with an Agilent 6520 QTOF-MS system was employed. Briefly, a 2.0 µL sample was injected and separated with an Agilent Zorbax Eclipse XDB-C18 column (narrow bore, 2.1 mm × 150 mm × 3.5 µm; Agilent Technologies, Santa Clara, CA, USA) at a flow rate of 0.5 mL/min.…”

Section: Methodsmentioning

confidence: 99%

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Antiparasitic Potential of Chromatographic Fractions of Nephrolepis biserrata and Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry Analysis

et al. 2021

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Marine aquaculture development is recently impeded by parasitic leech Zeylanicobdellaarugamensis (Hirudinea, Piscicolidae) in Sabah, Malaysia. The parasitic leech infests a variety of cultured fishes in aquaculture facilities. In this study, we evaluated the antiparasitic activity of the chromatographic fractions of the medicinal plant Nephrolepis biserrata methanol extract against Z.arugamensis and highlighted the potential metabolites responsible for the antiparasitic properties through liquid chromatography (LC)–quadrupole time-of-flight (QTOF)–mass spectrometry (MS) analysis. Out of seven fractions obtained through flash column chromatography techniques, three fractions demonstrated antiparasitic properties. Significant parasitic mortality was indicated by fraction 3 at a concentration of 2.50 mg/mL, all the leeches were killed in a time limit of 1.92 ± 0.59 min. followed by fraction 4 (14 mg/mL) in 34.57 ± 3.39 and fraction 5 (15.3 mg/mL) in 36.82 ± 4.53 min. LC-QTOF-MS analysis indicated the presence of secondary metabolites including phytosphingosine (6), pyrethrosin (1), haplophytine (9), ivalin (2), warburganal (3), isodomedin (4) and pheophorbide a (16), representing sphingoid, alkaloid, terpenoid, phenolic and flavonoid groups. Thus, our study indicated that the chromatographic fractions of N. biserrata demonstrated significant antiparasitic activity against the marine parasitic leeches due to the presence of potent antiparasitic bioactive compounds.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Antiparasitic Potential of Chromatographic Fractions of Nephrolepis biserrata and Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry Analysis

et al. 2021

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“…The histopathological analysis indicated that the plant extract protected the liver from harmful effects , such as fatty degeneration, necrosis, and inflammation. Moreover, transmission electron microscopy observations indicated that D. suffruticosa also reduced hepatocyte damage such as abnormal lamellar organization and endoplasmic reticulum dilations [ 90 , 91 ].…”

Section: Medicinal Plantsmentioning

confidence: 99%

Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms

et al. 2022

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Hepatotoxicity is a major global public health concern. Despite advances in modern medicine, the demerits of chemically prepared drugs outweigh their merits. In addition, the treatment of liver diseases based on modern medical principles has been found to produce several undesired side effects. Therefore, the exploration of medicinal plants has gained worldwide attention for treating various diseases, including liver diseases, owing to their potential efficacy and cost effectiveness. Several plants, including Andrographis paniculata, Bauhinia purpurea, Commelina nudiflora, Dillenia suffruticosa, Elaeis guineensis, Lygodium microphyllum, and Nephrolepis biserrata, have been reported with hepatoprotection. Moreover, these plants have been shown to play a vital role in ameliorating cellular damage because they contain several phytochemicals, including alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones. The following antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective compounds have been found in these plants: andrographolide, rosmarinic acid, phenol, eugenol, 9,12-octadecadienoic, n-hexadecanoic acid, dihydroxy dimethoxy flavone, sitosterol, demethoxycurcumin, quercetin, linoleic acid, stigmasterol, kojic acid, indole-2-one, α-terpinol, linalool, kaempferol, catechin, ellagic acid, and oleanolic acid. This paper aimed to provide an in-depth review of in vivo studies on Malaysian medicinal plants possessing hepatoprotective properties, phytochemical ingredients, and antioxidant mechanisms, with an emphasis on the species proven particularly useful for treating hepatic disorders.

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“…Among flavonoid compounds, Glyflavanone A has antioxidant and antiulcer activities [37]. Ponganone III is a chemopreventive agent [38] whereas 3,7,8,4 -tetrahydroxyflavone possesses antiparasitic activity [39]. 2-O-Caffeoylglucarate is a strong antioxidant agent [40].…”

Section: Uhplc-esi-qtof-ms Analysismentioning

confidence: 99%

Efficacy of Phytochemicals Derived from Roots of Rondeletia odorata as Antioxidant, Antiulcer, Diuretic, Skin Brightening and Hemolytic Agents—A Comprehensive Biochemical and In Silico Study

et al. 2022

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Roots of Rondeletia odorata are a rich source of phytochemicals with high antioxidant potential and thus may possess health benefits. This study used the LC-MS technique to identify phytoconstituents in R. odorata roots extract/fractions. Results revealed that n-butanol fraction and ethanolic extract contained total phenolic and flavonoid contents with values of 155.64 ± 0.66 mgGAE/g DE and 194.94 ± 0.98 mgQE/g DE, respectively. Significant potential of antioxidants was observed by DPPH, CUPRAC and FRAP methods while the ABTS method showed moderate antioxidant potential. Maximum % inhibition for urease, tyrosinase and carbonic anhydrase was shown by ethanolic extract (73.39 ± 1.11%), n-butanol soluble fraction (80.26 ± 1.59%) and ethyl acetate soluble fraction (76.50 ± 0.67%) which were comparable with thiourea (standard) (98.07 ± 0.74%), kojic acid (standard) (98.59 ± 0.92%) and acetazolamide (standard) (95.51 ± 1.29%), respectively, while all other extract/fractions showed moderate inhibition activity against these three enzymes. Hemolytic activity was also observed to range from 18.80 ± 0.42 to 3.48 ± 0.69% using the standard (triton X-100) method. In total, 28 and 20 compounds were identified tentatively by LC-MS analysis of ethanolic extract and n-butanol soluble fraction, respectively. Furthermore, molecular docking was undertaken for major compounds identified by LC-MS for determining binding affinity between enzymes (urease, tyrosinase and carbonic anhydrase) and ligands. It was concluded that active phytochemicals were present in roots of R. odorata with potential for multiple pharmacological applications and as a latent source of pharmaceutically important compounds. This should be further explored to isolate important constituents that could be used in treating different diseases.

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High-resolution chemical profiling and antiparasitic potential of the tropical shrub Dillenia suffruticosa

Cited by 4 publications

References 29 publications

Antiparasitic Potential of Chromatographic Fractions of Nephrolepis biserrata and Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry Analysis

Antiparasitic Potential of Chromatographic Fractions of Nephrolepis biserrata and Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry Analysis

Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms

Efficacy of Phytochemicals Derived from Roots of Rondeletia odorata as Antioxidant, Antiulcer, Diuretic, Skin Brightening and Hemolytic Agents—A Comprehensive Biochemical and In Silico Study

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