High‐resolution dynamic oxygen‐17 MR imaging of mouse brain with golden‐ratio–based radial sampling and k‐space–weighted image reconstruction

Abstract

Purpose: The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 ( 17 O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of 17 O water uptake and washout in the brains of mice with glioblastoma (GBM). Methods: A 3D imaging method with a stack-of-stars goldenratio-based radial sampling scheme was employed to acquire 17 O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution. Simulation studies were performed to validate the method. Using this method, the kinetics of 17 O water uptake and washout in the brains of mice with GBM were delineated after an intravenous bolus injection of 17 O water kinetics in vivo with high temporal and spatial resolution. It can also be used to image cerebral oxygen consumption rate in oxygen-17 inhalation studies.

Dynamic oxygen‐17 MRI with adaptive temporal resolution using golden‐means‐based 3D radial sampling

“…Previously, we used a golden‐ratio‐based, stack‐of‐stars sampling scheme in combination with k ‐space–weighted image contrast (KWIC) reconstruction strategy for improved spatial and temporal resolution 15 . We were able to achieve a voxel size of 11.25 µL and a temporal resolution of 7.56 s in an H 2 17 O injection study performed on mice.…”