Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics

Alambyan, Vilakshan; Pace, Jonathan; Sukpornchairak, Persen; Yu, Xin; Alnimir, Hamza; Tatton, Ryan; Chitturu, Gautham; Yarlagadda, Anisha; Ramos-Estébanez, Ciro

doi:10.1007/s13311-020-00843-4

Cited by 2 publications

(2 citation statements)

References 195 publications

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“…MRI offers accurate and precise estimation of cellular level neuroenergetic abnormality. Metabolic MRI monitors the process of astrogliosis and its correlation with the neuronal connective pathway over a period ( Hao et al, 2016 ; Alambyan et al, 2020 ). Laboratory methods assess the reactive astrocytes proliferation, glial scar formation for monitoring subtle changes during pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Mapping the research trends of astrocytes in stroke: A bibliometric analysis

Ding

Jiang

Yang

et al. 2022

Front. Cell. Neurosci.

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BackgroundStroke, including ischemic stroke and hemorrhagic stroke, possesses complex pathological mechanisms such as neuroinflammation, oxidative stress and blood-brain barrier damage. Astrocyte functions have been reported during injury, neuroprotection and cell crosstalk. It plays a key role in exacerbating stroke injury, promoting neurological repair and enhancing neuroregeneration.AimThis holistic bibliometric analysis aimed to provide a general overview of the recent advancement and the hotspots in the field of stroke and astrocyte from 2001 to 2021.Materials and methodsPublications between 2001 and 2021, related to stroke and astrocyte were retrieved from the Web of Science (WOS) and analyzed in Gephi and VOSviewer.ResultsIn total, 3789 documents were extracted from the WOS databases. The publications showed stable growth since 2001. The United States and China were the most prolific countries and University of California San Francisco and Oakland University were the most influential institutes. The top four most productive journals were Brain Research, Journal of Cerebral Blood Flow and Metabolism, Glia and Journal of Neuroinflammation. Keywords frequency and co-occurrence analysis revealed that the topics related to “micro-RNA”, “toll like receptor”, “neuroinflammation”, “autophagy” and “interleukin” were research frontiers. The field of stroke and astrocyte focused on several aspects, such as the role of astrocytes in the treatment of stroke, metabolic changes in astrocytes, the protective role of apoptosis in astrocytes after oxidative stress injury and neurovascular units.ConclusionThis comprehensive bibliometric study provides an updated perspective on the trend of research associated with stroke and astrocyte. It will benefit scientific community to identify the important issues, future directions and provide a novel understanding of stroke pathophysiology, hotspots and frontiers to facilitate future research direction.

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Section: Discussionmentioning

confidence: 99%

Mapping the research trends of astrocytes in stroke: A bibliometric analysis

Ding

Jiang

Yang

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Saadoun and Papadopolous review the monitoring of spinal cord blood flow after acute injury, revealing distinct blood flow patterns (e.g., local steal and diastolic ischemia) that may enable optimized and individualized spinal cord perfusion therapy [18]. Also, Alambyan et al discuss noninvasive metabolic imaging as a tool for molecular level energy exchange to guide targeted management in a diverse array of neuropathology [19]. Additionally, Hosseini et al assess potential combination therapies (e.g., pharmacotherapy, perfusion/oxygenation targets, and pre/post-conditioning) with targeted temperature management after hypoxicischemic brain injury [20].…”

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confidence: 99%

Translational Neurocritical Care Research: Advancing Understanding and Developing Therapeutics

Hemphill

James

2020

Neurotherapeutics

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Imaging Guidance for Therapeutic Delivery: The Dawn of Neuroenergetics

Cited by 2 publications

References 195 publications

Mapping the research trends of astrocytes in stroke: A bibliometric analysis

Mapping the research trends of astrocytes in stroke: A bibliometric analysis

Translational Neurocritical Care Research: Advancing Understanding and Developing Therapeutics

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