High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D

Krüger, Diana; Galli, S.; Zeller‐Plumhoff, Berit; Wieland, D. C. Florian; Peruzzi, Niccolò; Wiese, Björn; Heuser, Philipp; Wennerberg, Ann; Willumeit‐Römer, Regine

doi:10.1016/j.bioactmat.2021.10.041

Cited by 31 publications

(47 citation statements)

References 49 publications

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“…By contrast, Krüger et al . found similar BIC of Mg-xGd implants to Ti-implants in a rat study [ 13 ]. Castellani et al .…”

Section: Discussionmentioning

confidence: 82%

“…The labels residual material (non-corroded alloy), degradation layer (corrosion products attached to the residual material), bone (mineralized tissue) and background (all remaining features not assigned to previously mentioned labels) were distinguished. The segmented data were used for quantitative analysis of parameters describing degradation of implants, osseointegration and bone regeneration over the healing process [ 13 ]. Prior to the analysis of VL and DR, the alignment of non-degraded screw and ROIs of degraded screw were necessary.…”

Section: Methodsmentioning

confidence: 99%

“…The entire implant was investigated in the distal meta- and epiphysis. To gain a more detailed insight into bone growth and degradation in the different bone types, smaller regions of interest were evaluated using high-resolution SRµCT measurements [ 13 , 14 ] and histology [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Marek

Ćwieka

Donohue

et al. 2022

Regenerative Biomaterials

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Magnesium (Mg)-based implants are highly attractive for the orthopedic field and may replace titanium (Ti) as support for fracture healing. To determine the implant-bone-interaction in different bony regions, we implanted Mg-based alloy ZX00 (Mg < 0.5 Zn < 0.5 Ca, in wt%) and Ti-screws into the distal epiphysis and distal metaphysis of sheep tibiae. The implant degradation and osseointegration were assessed in vivo and ex vivo after 4, 6 and 12 weeks, using a combination of clinical computed tomography (cCT), medium-resolution micro CT (µCT) and high-resolution synchrotron radiation µCT (SRµCT). Implant volume loss, gas formation, and bone growth were evaluated for both implantation sites and each bone region independently. Additionally, histological analysis of bone growth was performed on embedded hard-tissue samples. We demonstrate that in all cases, the degradation rate of ZX00-implants ranges between 0.23-0.75 mm/year. The highest degradation rates were found in the epiphysis. Bone-to-implant-contact varied between the time points and bone types for both materials. Mostly, bone-volume-to-total-volume was higher around Ti-implants. However, we found an increased cortical thickness around the ZX00-screws when compared to the Ti-screws. Our results showed the suitability of ZX00-screws for implantation into the distal meta- and epiphysis.

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“…By contrast, Krüger et al . found similar BIC of Mg-xGd implants to Ti-implants in a rat study [ 13 ]. Castellani et al .…”

Section: Discussionmentioning

confidence: 82%

Section: Methodsmentioning

confidence: 99%

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Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Marek

Ćwieka

Donohue

et al. 2022

Regenerative Biomaterials

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“…Bone is a hierarchical material that requires studying at several scales with each hierarchical level containing significant information. Macro-to micro-scale investigations are conducted to study the bone-to-implant interface and bone volume to total volume in order to assess the overall osseointegration of the implant [ 1 , 2 ]. Scaling further to the nanoscale, the study and imaging of bone cell arrangement can be achieved [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study

Espiritu

Sefa

Ćwieka

et al. 2023

Bioactive Materials

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“…In addition, discussions on possible tissue retention and potential adverse effects are ongoing. [17,18] Further alloy development through microalloying is suggested to offset the cost of REs without compromising their properties. Therefore, a thermomechanical process with a small amount of Gd added to Mg is suggested to obtain excellent mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Effects of Minor Gadolinium Addition and T4 Heat Treatment on Microstructure and Properties of Magnesium

Huang

Bode³

et al. 2022

Adv Eng Mater

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Mg–Gd alloys are candidates for degradable implants combining favorable mechanical and corrosion properties. Gd has a high solid solubility in Mg and an acceptable biocompatibility. The influences of different amount of Gd additions and solid solution (T4) treatment on mechanical properties and corrosion in 0.9 wt% NaCl and cell culture medium (CCM) of magnesium are systematically investigated. The effects of Gd are clarified by microstructural characterizations as well as stress and degradation analysis. It is shown that minor Gd additions to pure Mg lead to Gd solid solution in Mg (α) and the formation of Mg5Gd intermetallic particles (IMPs), which increase the hardness, tensile, and compressive strength. The GdH2 phase is found in low‐alloyed Mg–Gd alloys. The corrosion rate (CR) is increased by the addition of more Gd due to the increased kinetics of the cathodic reaction. However, the resistance to degradation is effectively improved by T4 heat treatment due to the dissolution of IMPs. The reduced susceptibility to pitting can be achieved by a minor Gd addition and T4 heat treatment. The Mg–2Gd alloy is a potential candidate for implants due to its good combination of tailorable mechanical properties and low homogeneous in vitro degradation rate (DR).

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High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D

Cited by 31 publications

References 49 publications

Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Degradation behavior and osseointegration of Mg–Zn–Ca screws in different bone regions of growing sheep: a pilot study

Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study

Effects of Minor Gadolinium Addition and T4 Heat Treatment on Microstructure and Properties of Magnesium

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