High-resolution imaging of proteins in human teeth by scanning probe microscopy

Gruverman, Alexei; Wu, Dong; Rodriguez, Brian J.; Kalinin, Sergei V.; Habelitz, Stefan

doi:10.1016/j.bbrc.2006.10.182

Cited by 36 publications

(29 citation statements)

References 38 publications

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“…These behaviors often average out in macroscopic biological assemblies, since the piezoelectric effect is described by third rank tensor. However, on the nanoscale these polar regions are readily visualized by PFM, providing spectacular images of bones, 141 antlers 142 teeth, [143][144][145][146][147] and even butterfly wings. 147 Several examples are shown in Figure 4.…”

Section: Iia Basic Pfmmentioning

confidence: 99%

Ferroelectric or non-ferroelectric: Why so many materials exhibit “ferroelectricity” on the nanoscale

Vasudevan

Balke

Maksymovych

et al. 2017

Applied Physics Reviews

270

206

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Ferroelectric materials have remained one of the foci of condensed matter physics and materials science for over 50 years. In the last 20 years, the development of voltage-modulated scanning probe microscopy techniques, exemplified by Piezoresponse force microscopy (PFM) and associated time-and voltage spectroscopies, opened a pathway to explore these materials on a single-digit nanometer level. Consequently, domain structures, walls and polarization dynamics can now be imaged in real space. More generally, PFM has allowed studying electromechanical coupling in a broad variety of materials ranging from ionics to biological systems. It can also be anticipated that the recent Nobel prize 1 in molecular electromechanical machines will result in rapid growth in interest in PFM as a method to probe their behavior on single device and device assembly levels. However, the broad introduction of PFM also resulted in a growing number of reports on nearly-ubiquitous presence of ferroelectric-like phenomena including remnant polar states and electromechanical hysteresis loops in materials which are non-ferroelectric in the bulk, or in cases where size effects are expected to suppress ferroelectricity. While in certain cases plausible physical mechanisms can be suggested, there is remarkable similarity in observed behaviors, irrespective of the materials system. In this review, we summarize the basic principles of PFM, briefly discuss the features of ferroelectric surfaces salient to PFM imaging and spectroscopy, and summarize existing reports on ferroelectric-like responses in non-classical ferroelectric materials. We further discuss possible mechanisms behind observed behaviors, and possible experimental strategies for their identification.3

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Section: Iia Basic Pfmmentioning

confidence: 99%

Ferroelectric or non-ferroelectric: Why so many materials exhibit “ferroelectricity” on the nanoscale

Vasudevan

Balke

Maksymovych

et al. 2017

Applied Physics Reviews

270

206

View full text Add to dashboard Cite

show abstract

“…New imaging capabilities offered by PFM have resulted in breakthrough results ranging from detection of piezoelectricity in a butterfly wing to realspace imaging of electromechanically active protein fibrils in calcified and connective tissues-accomplishments unattainable by other experimental techniques. [30][31][32][33] Collagen-type proteins represent a key structural component of biological materials and systems. Assessment of the relationship between piezoelectric properties and molecular structure of proteins is an important step toward the understanding of the physico-chemical properties of biological systems and development of biologically inspired materials and devices.…”

Section: B Orientational Imaging Of Electromechanical Properties Of mentioning

confidence: 99%

Orientational imaging in polar polymers by piezoresponse force microscopy

Sharma

Poddar

et al. 2011

Journal of Applied Physics

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We report orientational imaging of the polarization distribution in nanostructured ferroelectric copolymer of polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE) and collagen fibrils using vertical and lateral modes of piezoresponse force microscopy (PFM). In PVDF-TrFE, detection of azimuthal variations in the lateral PFM signal is attributed to the alignment of the molecular chains along different directions. Local switching in PVDF-TrFE is shown to proceed via 120 or 180 rotation of dipoles around the molecular chain, depending upon the strength of the applied electric field. Analysis of the vertical and lateral PFM signals in collagen reveals polar anisotropy of the electromechanical properties along the axes of the fibrils. The surface plots of the piezoelectric response are constructed for both materials based on their piezoelectric tensors and are shown to be consistent with the observed vertical and lateral PFM maps.

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“…58 Furthermore, the 2010 Preface also predicted opportunities for new discoveries and breakthroughs in biological systems and strongly correlated oxides, and one of the exciting developments in the last two years is the observation of biological ferroelectricity in seashells, 22 aortic walls, 23 elastin, 24 glycine, 25 and peptide nanotubes, 26 which came more than 50 years after the closely related piezoelectricity was reported in biological tissues and 5 years after ubiquitous presence of biological piezoelectricity was established by PFM. [27][28][29][30][31] This advance is undoubtedly enabled by PFM, as vividly illustrated by Li and Zeng in their detailed studies on electromechanical coupling and ferroelectric switching of seashell in the present issue. 59 Another exciting development is recent realization of polarization reversal by mechanical stress, 32 attributed to the flexoelectric effect afforded by nanoscale Scanning Probe Microscopy (SPM) tip.…”

mentioning

confidence: 66%

Preface to Special Topic: Selected Papers from the Piezoresponse Force Microscopy Workshop Series: Part of the Joint ISAF-ECAPD-PFM 2012 Conference

Kalinin

Kholkin

2013

Journal of Applied Physics

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High-resolution imaging of proteins in human teeth by scanning probe microscopy

Abstract: Kalinin, Sergei V.; and Habelitz, S., "High-resolution imaging of proteins in human teeth by scanning probe microscopy" (2006). Alexei Gruverman Publications. 24.

Cited by 36 publications

References 38 publications

Ferroelectric or non-ferroelectric: Why so many materials exhibit “ferroelectricity” on the nanoscale

Ferroelectric or non-ferroelectric: Why so many materials exhibit “ferroelectricity” on the nanoscale

Orientational imaging in polar polymers by piezoresponse force microscopy

Preface to Special Topic: Selected Papers from the Piezoresponse Force Microscopy Workshop Series: Part of the Joint ISAF-ECAPD-PFM 2012 Conference

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