Glacier hypsometry provides a first-order approach for assessing a glacier's response to climate forcings. We couple the Randolph Glacier Inventory to a suite of in situ observations and climate model output to examine potential change for the ∼27,000 glaciers in Alaska and northwest Canada through the end of the 21st century. By 2100, based on Representative Concentration Pathways (RCPs) 4.5-8.5 forcings, summer temperatures are predicted to increase between +2.1 and +4.6 ∘ C, while solid precipitation (snow) is predicted to decrease by −6 to −11%, despite a +9 to +21% increase in total precipitation. Snow is predicted to undergo a pronounced decrease in the fall, shifting the start of the accumulation season back by ∼1 month. In response to these forcings, the regional equilibrium line altitude (ELA) may increase by +105 to +225 m by 2100. The mass balance sensitivity to this increase is highly variable, with the most substantive impact for glaciers with either limited elevation ranges (often small (<1 km 2 ) glaciers, which account for 80% of glaciers in the region) or those with top-heavy geometries, like icefields. For more than 20% of glaciers, future ELAs, given RCP 6.0 forcings, will exceed the maximum elevation of the glacier, resulting in their eventual demise, while for others, accumulation area ratios will decrease by >60%. Our results highlight the first-order control of hypsometry on individual glacier response to climate change, and the variability that hypsometry introduces to a regional response to a coherent climate perturbation.