High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma

Abstract

The new imaging concept shows a trend towards improving the accuracy of detecting metastatic risk factors in children with retinoblastoma and is therefore recommended for pretherapeutic imaging and follow-up.

High-resolution MRI using orbit surface coils for the evaluation of metastatic risk factors in 143 children with retinoblastoma

“…However, an additional prospective study would be necessary to confirm this finding. In the interpretation of these results, it has to be considered that new image concepts using two orbit surface coils seem to improve the detection of choroidal invasion, especially of massive choroidal invasion further [29,31].…”

“…Additionally, different scanners and surface coils (4-and 7-mm diameter) were used in their setting, which might have influenced the results. Newer image concepts using two orbit surface coils and newer MR scanners might further improve the detection rate for postlaminar optic nerve infiltration [29,31].…”

“…In all children, 1-channel, linear polarized orbit surface coils with a diameter of 4 cm were used for imaging. Between February 2007 and June 2010, one orbit surface coil focused on the (most) effected eye was used for imaging, afterwards a new image concept with two orbit surface coils was established (for details please see Sirin et al [31]). All sequences performed with the orbit surface coil(s) had a measured voxel of 0.43×0.21×2 mm, after interpolation 0.21×0.21×2 mm.…”

Diagnosis of Postlaminar Optic Nerve Invasion in Retinoblastoma With MRI Features

“…Prior studies have shown that PLONI can be diagnosed by the presence of optic nerve enhancement or tumor size (volume) . In a recent meta‐analysis, De Jong et al reported the sensitivity and specificity of MRI in detecting PLONI was 59% and 94%, respectively.…”

“…Prior studies have shown that PLONI can be diagnosed by the presence of optic nerve enhancement or tumor size (volume). 19,20,[23][24][25]28,[30][31][32] In a recent meta-analysis, De Jong et al 18 reported the sensitivity and specificity of MRI in detecting PLONI was 59% and 94%, respectively. In our study, the optimal cutoff value was selected as the point when the Youden index was maximal and resulted in a higher sensitivity and accuracy for predicting PLONI (82% and 77%, respectively) compared to the aforementioned results.…”