High-resolution NMR spectroscopy for measuring complex samples based on chemical-shift-difference selection

Numerous 1 H− 1 H J couplings contribute to complex multiplets in 1 H nuclear magnetic resonance spectroscopy, leading to an ambiguous spectral assignment, particularly for strongly coupled protons. Although the PSYCHE approach has proven to be effective in simplifying complex spectra by collapsing J couplings, the PSYCHE pure shift spectrum of strongly coupled protons always suffers from sideband artifacts and baseline oscillations, which impede spectral identification. Herein, we introduce a novel universal technique designed to separate artifacts from the desired absorption-mode pure shift signals. This new study will significantly benefit the development of molecular structure elucidations and composition analysis in the fields of chemistry, biochemistry, and metabonomics.

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High-resolution NMR spectroscopy for measuring complex samples based on chemical-shift-difference selection

Abstract: NMR spectroscopy serves as an immensely powerful tool for component assignments and molecular structure elucidations. However, proton NMR spectra are generally trapped with spectral congestion caused by limited frequency differences...

Cited by 2 publications

References 45 publications

Chemical constituents of Ulmus pumila L. and their chemotaxonomic significance

Chemical constituents of Ulmus pumila L. and their chemotaxonomic significance

ELSA-PSYCHE: An Improved Method for Protecting Pure Shift Spectra from Artifacts

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