High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele

Pellacani, Giovanni; Casali, Bruno; Malagoli, Carlotta; Nicoli, Davide; Farnetti, Enrico; Bassissi, Stefania; Bergomi, Margherita; Seidenari, Stefania

doi:10.1097/01.cmr.0000198450.19204.dd

Cited by 15 publications

(9 citation statements)

References 16 publications

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“…[104][105][106] In one study, individuals carrying at least one variant ICAM-1 SNP R241 allele (conferring increased ICAM-1 expression) versus wild-type GG genotype had a 4.3 relative risk of melanoma (P = .022). 103 However, in this study, the CMM patient and control sample sizes each only numbered 59, so larger studies are needed to confirm this preliminary finding.…”

Section: Immune-related Genesmentioning

confidence: 82%

“…ICAM-1 appears to play a role in the inflammatory and immune response through its interaction with the leukocyte integrins leukocyte function-associated antigen-1 (LFA-1) and Mac-1. 103,104 Higher levels of ICAM-1 may therefore interfere with lymphocyte recognition of tumor cells and lymphocyte localization. [104][105][106] In one study, individuals carrying at least one variant ICAM-1 SNP R241 allele (conferring increased ICAM-1 expression) versus wild-type GG genotype had a 4.3 relative risk of melanoma (P = .022).…”

Section: Immune-related Genesmentioning

confidence: 99%

See 1 more Smart Citation

Germline melanoma susceptibility and prognostic genes: A review of the literature

Ward

Lazovich

Hordinsky

2012

Journal of the American Academy of Dermatology

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Section: Immune-related Genesmentioning

confidence: 82%

Section: Immune-related Genesmentioning

confidence: 99%

Germline melanoma susceptibility and prognostic genes: A review of the literature

Ward

Lazovich

Hordinsky

2012

Journal of the American Academy of Dermatology

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“…Overexpression of ICAM-1 in melanoma, gastric, breast, renal cell carcinoma and colorectal cancer has been shown (Arandi et al, 2008). The SNP in ICAM1 gene has been also reported which is correlated with the risk of cancers, such as breast cancer, colorectal cancer and melanoma (Howell et al, 2005;Cox et al, 2006;Vinceti et al, 2006;Wang et al, 2009). In our study, genotype and allele distribution of ICAM K469E were not observed statistically significant difference between patients with brain tumors and control group.…”

Section: Discussionmentioning

confidence: 99%

“…K469E polymorphism has been found to affect the splicing ICAM-1 mRNA (Iwao et al, 2004;Thanopoulou et al, 2012). This polymorhisms has been studied in various types of malignancies with disparate conclusions (Macchioni et al, 2000;Nakata et al, 2000;Salvarani et al, 2000;Alexiou et al, 2003;Vigano et al, 2003;Lee et al, 2004;Theodoropoulos et al, 2006;Vinceti et al, 2006;Brand et al, 2011;Eggeman et al, 2011). To the best of our knowledge, no published study has investigated the role of polymorphisms of the ICAM-1 and ITGB3 genes on the risk of primary brain tumors.…”

Section: Introductionmentioning

confidence: 99%

Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors

Yılmaz

Zeybek²,

Kahraman³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Primary brain tumors constitute a small percent of all malignant cancers, but their etiology remains poorly understood. β3 integrin (ITGB3) has been recognized to play influential roles in angiogenesis, tumor growth and metastasis. Intercellular adhesion molecule-1 (ICAM-1) is a surface glycoprotein important for tumor invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and ITGB3 could be associated with brain cancer development and progression in a Turkish population. Our study is the first to our knowledge to investigate the relationship between brain tumor risk and ICAM-1 and β3 integrin gene polymorphisms. Materials and Methods: The study covered 92 patients with primary brain tumors and 92 age-matched healthy control subjects. Evaluation of β3 integrin (Leu33Pro (rs5918)) and ICAM-1 (R241G (rs1799969) and K469E (rs5498)) gene polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: According to results of our research, the A allele of the ICAM-1 R241G gene polymorphism appeared to be a risk factor for primary brain tumors (p<0.001). Similarly, the frequency of the A mutant allele of ICAM-1 R241G was statistically significant in patients with brain tumors classified as glioma (p<0.001). When allele and genotype distributions of ICAM-1 K469E, ICAM-1 R241G and β3 integrin Leu33Pro gene polymorphisms were evaluated with age, sex, and smoking, there were no statistically significant differences. Haplotype analysis revealed that the frequencies of GAC (rs1799969-rs5498-rs5918) and GAT (rs1799969-rs5498-rs5918) haplotypes were significantly lower in patients as compared with controls (p=0.001; p=0.036 respectively). Conclusions: This study provides the first evidence that ICAM-1 R241G SNP significantly contributes to the risk of primary brain tumors in a Turkish population. In addition, our results suggest that ICAM-1 R241G in combination ICAM-1 K469E may have protective effects against the development of brain cancer.

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“…Polymorphisms of the ICAM-1 gene have previously been found to be significantly associated with rheumatoid arthritis [14] , inflammatory bowel disease [15] , melanoma [16] , Behçet's disease [17] , and multiple sclerosis [18] .…”

Section: Icam-1 and Il-6 Gene Polymorphism In Endometriosismentioning

confidence: 99%

Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis

Chae

Lee

Choi³

et al. 2010

Gynecol Obstet Invest

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Background/Aims: The aim of this study was to investigate the possibility that the K469E and G241R polymorphisms in the intercellular adhesion molecule-1 (ICAM-1) gene and the C-634G polymorphism in the interleukin (IL)-6 gene are associated with endometriosis in the Korean population. Methods: The ICAM-1 gene K469E and G241R polymorphisms and the IL-6 gene C-634G polymorphism were evaluated in 390 patients with endometriosis and 351 controls by polymerase chain reaction-restriction fragment length polymorphism analysis. Results: The ICAM-1 gene G241R polymorphism was not observed in all subjects. No differences were observed in the ICAM-1 K469E and IL-6 C-634G genotype distributions and allele frequencies between patients with endometriosis and controls. In subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometriomas, no significant differences were observed in the ICAM-1 gene K469E or the IL-6 gene C-634G polymorphism frequencies between the subgroups and the controls. The combined analysis of the ICAM-1 gene K469E polymorphism and the IL-6 gene C-634G polymorphism did not show any additional significant findings. Conclusions: The K469E and G241R polymorphisms in the ICAM-1 gene and the C-634G polymorphism in the IL-6 gene may not be genetic factors related to susceptibility to advanced-stage endometriosis in the Korean population.

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High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele

Cited by 15 publications

References 16 publications

Germline melanoma susceptibility and prognostic genes: A review of the literature

Germline melanoma susceptibility and prognostic genes: A review of the literature

Investigation of ICAM-1 and β3 Integrin Gene Variations in Patients with Brain Tumors

Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis

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