High risk of polydipsia and water intoxication in schizophrenia patients

González, Idilio; Peñas-Lledó, Eva; Pérez, Nancy Estévez; Rubia, Alfredo de la; LLerena, Adrián

doi:10.1016/j.schres.2007.05.027

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…This disease appears to be associated with certain individual characteristics, namely male gender, chronic disease, heavy smoking, alcohol abuse and even certain psychiatric illnesses, such as schizophrenia and cognitive deficits. ( 3 )…”

Section: Discussionmentioning

confidence: 99%

Recurrent rhabdomyolysis secondary to hyponatremia in a patient with primary psychogenic polydipsia

Aguiar¹,

Monteiro²,

Coutinho³

2015

Revista Brasileira De Terapia Intensiva

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Rhabdomyolysis is characterized by the destruction of skeletal muscle tissue, and its main causes are trauma, toxic substances and electrolyte disturbances. Among the latter is hyponatremia-induced rhabdomyolysis, a rare condition that occurs mainly in patients with psychogenic polydipsia. Psycogenic polydipsia mostly affects patients with schizophrenia, coursing with hyponatremia in almost 25% of the cases. It is also in this context that rhabdomyolysis secondary to hyponatremia occurs most often. In this article, the case of a 49-year-old male with a history of schizophrenia, medicated with clozapine, and brought to the emergency room in a state of coma and seizures is described. Severe hypoosmolar hyponatremia with cerebral edema was found on a computed tomography examination, and a subsequent diagnosis of hyponatremia secondary to psychogenic polydipsia was made. Hyponatremia correction therapy was started, and the patient was admitted to the intensive care unit. After the hyponatremia correction, the patient presented with analytical worsening, showing marked rhabdomyolysis with a creatine phosphokinase level of 44.058UI/L on day 3 of hospitalization. The condition showed a subsequent progressive improvement with therapy, with no occurrence of kidney damage. This case stresses the need for monitoring rhabdomyolysis markers in severe hyponatremia, illustrating the condition of rhabdomyolysis secondary to hyponatremia induced by psychogenic polydipsia, which should be considered in patients undergoing treatment with neuroleptics.

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Section: Discussionmentioning

confidence: 99%

Recurrent rhabdomyolysis secondary to hyponatremia in a patient with primary psychogenic polydipsia

Aguiar¹,

Monteiro²,

Coutinho³

2015

Revista Brasileira De Terapia Intensiva

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“…This condition was found in up to 47% of psychiatry inpatients in series from Cuba, with almost 7% developing hyponatremia [19]. Hyponatremia occurs if the volume of water ingestion exceeds the excretory capacity of the kidneys.…”

Section: Acute Hypotonic Hyponatremiamentioning

confidence: 99%

Dysnatremia in the ICU

Pokaharel

Block

2011

Current Opinion in Critical Care

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“…Patients can present with a range of symptoms from nausea, vomiting to confusion, seizures and loss of consciousness. The condition has been widely reported in the literature amongst endurance athletes [1,2], psychiatric patients [3][4][5][6][7][8][9][10][11] and military recruits [12,13]. Water intoxication has also been reported in patients preparing for imaging studies that require fluid preparation such as abdominal or pelvic ultrasonography [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Severe Hyponatremia From Water Intoxication Associated With Preparation for a Urine Flow Study

2012

J Med Cases

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To discuss the natural history and impact of hyponatremia secondary to water intoxication in the setting of a urine flow study. Case report and literature review. An 82 year old male developed severe hyponatraemia following preparation for a urine flow study as part of ongoing follow up of lower urinary tract symptoms. He was admitted to an intensive care unit after developing acute confusion with a sodium of 114 mmol/L and discharged after his symptoms improved with slow correction of his sodium level. There are few reports in the literature of this event and no consensus guidelines on safe preparation for flow studies or other imaging modalities requiring pre-procedural fluid hydration. Patients with medications or conditions predisposing to hyponatremia are at higher risk of adverse events when overhydration occurs. Hyponatremia is a major adverse outcome of urine flow studies. Wider reporting of this condition is required to improve awareness of its effects and develop consensus guidelines on preventing its occurrence.

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High risk of polydipsia and water intoxication in schizophrenia patients

Cited by 6 publications

References 8 publications

Recurrent rhabdomyolysis secondary to hyponatremia in a patient with primary psychogenic polydipsia

Recurrent rhabdomyolysis secondary to hyponatremia in a patient with primary psychogenic polydipsia

Dysnatremia in the ICU

Severe Hyponatremia From Water Intoxication Associated With Preparation for a Urine Flow Study

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