High risk of temporary alteration of semen parameters after recent acute febrile illness

Sergerie, Martin; Mieusset, R.; Croute, F.; Daudin, Myriam; Bujan, Louis

doi:10.1016/j.fertnstert.2006.12.045

Cited by 153 publications

(133 citation statements)

References 39 publications

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“…Exclusion criteria were: pharmacologic therapies and high fever (28,29) within the preceding 100 days; sexual abstinence >7 or <2 days (7); and incomplete collection of semen sample (30). sDF variability was expressed as coefficient of variation (CV) ¼ (SD/mean of the two determinations) Â 100.…”

Section: Interindividual Variabilitymentioning

confidence: 99%

“…Such a difference could be due to the recruitment criteria adopted in our study that, at variance with the above studies (36)(37)(38), excluded any conditions among those that so far are known to affect sDF (including recent pharmacologic therapies and fever episodes [28,29]). Indeed, when some of these conditions are excluded, the variability of sDF results decreased ($20% [39]).…”

Section: Figurementioning

confidence: 99%

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DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters

Muratori

Marchiani

Tamburrino

et al. 2015

Fertility and Sterility

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Objective: To evaluate whether sperm DNA fragmentation (sDF), measured in brighter, dimmer, and total populations, predicts natural conception, and to evaluate the intra-individual variability of sDF. Design: Prospective study. Setting: Outpatient clinic and diagnostic laboratory. Patient(s): A total of 348 unselected patients and 86 proven fertile men. Intervention(s): None. Main Outcome Measure(s): sDF was revealed with the use of terminal deoxynucleotide transferase-mediated dUTP nick-end labeling (TUNEL)/propidium iodide (PI). Receiver operating characteristic (ROC) curves were built before and after matching fertile men to patients for age (76:152) or semen parameters (68:136) or both (49:98). Intra-individual variability of sDF was assessed over 2 years. Result(s): Brighter (area under ROC curve [AUC] 0.718 AE 0.54), dimmer (AUC 0.655 AE 0.63), and total (AUC 0.757 AE 0.54) sDF predict male fertility in unmatched and age-or semen parameters-matched subjects. After matching for both age and semen parameters, only brighter (AUC 0.711 AE 0.83) and total (AUC 0.675 AE 0.92) sDF predict male fertility. At high values of total sDF, brighter predicts natural conception better than total sDF. Intra-individual coefficients of variation of sDF were 9.2 AE 8.6% (n ¼ 25), 12.9 AE 12.7% (n ¼ 53), and 14.0 AE 12.6% (n ¼ 70) over, respectively, 100-day and 1-and 2-year periods, appearing to be the most stable of the evaluated semen parameters. Conclusion(s):The predictive power of total sDF partially depends on age and semen parameters, whereas brighter sDF independently predicts natural conception. Therefore, brighter sDF is a fraction of sDF that adds new information to the routine semen analysis. At high levels of sDF, distinguishing the two sperm populations improves the predictive power of sDF. Overall, our results support the idea that TUNEL/PI can be of clinical usefulness in the male fertility workup. (Fertil Steril Ò 2015;104:582-90. Ó2015 by American Society for Reproductive Medicine.)

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Section: Interindividual Variabilitymentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters

Muratori

Marchiani

Tamburrino

et al. 2015

Fertility and Sterility

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“…25 Furthermore, sperms lack antioxidants and DNA repair systems, 26 and protection of the offspring from the negative effects of DNA strand breaks originating from the spermatozoa is completely dependent on the repair capacity of the oocyte and the early embryo. Leukocytes and abnormal spermatozoa in the semen are the main sources of ROS in semen; 14,27,28 however, increased scrotal temperature due to illness such as fever [29][30][31] or varicocele 32 are other reported sources. Also, older men are reported to have sperm with more DNA fragmentation than younger men, which is likely because of OS.…”

Section: Male Infertility/subfertilitymentioning

confidence: 99%

Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility

Bungum

Bungum²,

Giwercman³

2010

Asian J Androl

173

111

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Diagnosis of male infertility has mainly been based on the World Health Organization (WHO) manual-based semen parameter's concentration, motility and morphology. It has, however, become apparent that none of these parameters are reliable markers for evaluation of the fertility potential of a couple. A search for better markers has led to an increased focus on sperm chromatin integrity testing in fertility work-up and assisted reproductive techniques. During the last couple of decades, numerous sperm DNA integrity tests have been developed. These are claimed to be characterized by a lower intraindividual variation, less intralaboratory and interlaboratory variation and thus less subjective than the conventional sperm analysis. However, not all the sperm chromatin integrity tests have yet been shown to be of clinical value. So far, the test that has been found to have the most stable clinical threshold values in relation to fertility is the sperm chromatin structure assay (SCSA), a flow cytometric test that measures the susceptibility of sperm DNA to acid-induced DNA denaturation in situ. Sperm DNA fragmentation as measured by SCSA has shown to be an independent predictor of successful pregnancy in first pregnancy planners as well as in couples undergoing intrauterine insemination, and can be used as a tool in investigation, counseling and treatment of involuntary childlessness. More conflicting data exist regarding the role of sperm DNA fragmentation in relation to fertilization, pre-embryo development and pregnancy outcome in in vitro fertilization and intracytoplasmic sperm injection (ICSI).

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“…A recent review reinforces the effect that various lifestyle factors have on sperm DNA integrity, including physical agents (e.g., chemotherapy or radiation), chemical agents (e.g., cigarette smoking), and biologic agents (e.g., sexually transmitted infections, BMI, and insulindependent diabetes mellitus) (11,12,(21)(22)(23). Other etiologies for sperm DNA damage include malignancies, recent febrile illness (24,25), and varicocele (26).…”

Section: Normal Sperm Parameters and Their Biologic Variationmentioning

confidence: 87%

Male fertility: psychiatric considerations

Hall

Burt²

2012

Fertility and Sterility

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High risk of temporary alteration of semen parameters after recent acute febrile illness

Cited by 153 publications

References 39 publications

DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters

DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters

Sperm chromatin structure assay (SCSA): a tool in diagnosis and treatment of infertility

Male fertility: psychiatric considerations

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