High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems

Xie, Jiayu; Wang, Danfeng; Ling, Shengan; Yang, Guang; Yang, Yufeng; Chen, Wenfeng

doi:10.3389/fnins.2019.01271

Cited by 16 publications

(14 citation statements)

References 71 publications

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“…The supplier reports that the AB152 successfully labeled TH in the striatum, sympathetic nerve terminals and adrenal glands. Staining of brain TH cells is significantly decreased in heterozygous TH‐knockout flies (Xie et al, 2019). In mice, AB152 was used in many studies for immunostaining of midbrain DA neurons in brain slices (e.g., Baron, Ratzka, & Grothe, 2012; Hennis, Seamans, Marvin, Casey, & Goldberg, 2013; Lobb, Zaheer, Smith, & Jaeger, 2013).…”

Section: Methodsmentioning

confidence: 99%

Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8–A13

Fougère

Zouwen

Boutin

et al. 2020

J of Comparative Neurology

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Co-transmission of glutamate by brain dopaminergic (DA) neurons was recently proposed as a potential factor influencing cell survival in models of Parkinson's disease. Intriguingly, brain DA nuclei are differentially affected in Parkinson's disease. Whether this is associated with different patterns of co-expression of the glutamatergic phenotype along the rostrocaudal brain axis is unknown in mammals. We hypothesized that, as in zebrafish, the glutamatergic phenotype is present preferentially in the caudal mesodiencephalic DA nuclei. Here, we used in mice a cell fate mapping strategy based on reporter protein expression (ZsGreen) consecutive to previous expression of the vesicular glutamate transporter 2 (Vglut2) gene, coupled with immunofluorescence experiments against tyrosine hydroxylase (TH) or dopamine transporter (DAT). We found three expression patterns in DA cells, organized along the rostrocaudal brain axis. The first pattern (TH-positive, DAT-positive, ZsGreenpositive) was found in A8-A10. The second pattern (TH-positive, DAT-negative, ZsGreen-positive) was found in A11. The third pattern (TH-positive, DAT-negative, ZsGreen-negative) was found in A12-A13. These patterns should help to refine the establishment of the homology of DA nuclei between vertebrate species. Our results also uncover that Vglut2 is expressed at some point during cell lifetime in DA nuclei known to degenerate in Parkinson's disease and largely absent from those that are preserved, suggesting that co-expression of the glutamatergic phenotype in DA cells influences their survival in Parkinson's disease.

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Section: Methodsmentioning

confidence: 99%

Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8–A13

Fougère

Zouwen

Boutin

et al. 2020

J of Comparative Neurology

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“…Although the DASH sodium component was not significant in this study, it is recognized that high-salt diets can affect sleep quality. Xie et al found that young Drosophila on high-salt diet exhibit a fragmented sleep phenotype similar to that of normal aging individuals [69]. The induced sleep changes were attributed to impaired circadian rhythms and were dopaminergic system dependent [69].…”

Section: Biological Plausibilitymentioning

confidence: 99%

“…Xie et al found that young Drosophila on high-salt diet exhibit a fragmented sleep phenotype similar to that of normal aging individuals [69]. The induced sleep changes were attributed to impaired circadian rhythms and were dopaminergic system dependent [69]. It is worth noting that approximately 10% of our selected sample were hypertensive with systolic blood pressure ≥150 mm Hg and/or diastolic blood pressure ≥90 mm Hg (7.2% in the 30-59 yo group; 20.1% in the 60+ yo group, P < 0.05, Wald test for age group difference), with no gender differences.…”

Section: Biological Plausibilitymentioning

confidence: 99%

Dietary Approaches to Stop Hypertension (DASH) Score and Its Association with Sleep Quality in a National Survey of Middle-Aged and Older Men and Women

et al. 2020

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Complex processes appear to link sleep duration and quality with dietary patterns. Numerous studies show healthful benefits of the Dietary Approaches to Stop Hypertension (DASH) diet, but few have examined its association with sleep duration or quality. The current study tested cross-sectional associations of DASH diet quality score with sleep quality among adults. Analyses of participants were from the 2005–2008 wave of the National Health and Nutrition Examination Surveys (n = 3941 adults ≥30 years of age, complete data). We performed sex- and age group-stratified multiple OLS regression analyses with DASH total score and components as main predictors and sleep quality as main outcomes, adjusting sequentially for socio-demographic, behavioral and health-related factors. Sex and age differences in associations of DASH with sleep quality, adjusting for covariates, were also examined by incorporating two-way interaction terms between sex/age and the DASH score in each unstratified model. We found that the DASH diet score was inversely related to poor sleep-related daytime dysfunction adjusted by age, sex, demographic and socio-economic factors. Some sex-specific associations were detected between DASH diet component scores and sleep quality. Notably, the potassium DASH component was inversely associated with Factor 1 (“sleepiness and sleep disturbance”) among women. The fiber DASH component was associated with better sleep quality and inversely related to Factor 2 (“sleep-related daytime dysfunction”) in younger subjects. This study indicates health benefits of the DASH diet for sleep duration and quality. Future longitudinal studies and randomized placebo-controlled trials are required to ascertain protective effects.

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“…Most people consume excessive amounts of salt-on average, about twice the maximum recommended amount [4]. An HSD can also negatively impact brain health, causing deficits in behavior and physiological processes such as cognitive function [5][6][7] and sleep [8,9]. However, how an HSD affects brain neuron function is still unclear.…”

Section: Introductionmentioning

confidence: 99%

High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes

Ling

et al. 2021

Nutrients

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Salt, commonly known as sodium chloride, is an important ingredient that the body requires in relatively minute quantities. However, consuming too much salt can lead to high blood pressure, heart disease and even disruption of circadian rhythms. The biological process of the circadian rhythm was first studied in Drosophila melanogaster and is well understood. Their locomotor activity gradually increases before the light is switched on and off, a phenomenon called anticipation. In a previous study, we showed that a high-salt diet (HSD) impairs morning anticipation behavior in Drosophila. Here, we found that HSD did not significantly disrupt clock gene oscillation in the heads of flies, nor did it disrupt PERIOD protein oscillation in clock neurons or peripheral tissues. Remarkably, we found that HSD impairs neuronal plasticity in the axonal projections of circadian pacemaker neurons. Interestingly, we showed that increased excitability in PDF neurons mimics HSD, which causes morning anticipation impairment. Moreover, we found that HSD significantly disrupts neurotransmitter-related biological processes in the brain. Taken together, our data show that an HSD affects the multiple functions of neurons and impairs physiological behaviors.

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High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems

Cited by 16 publications

References 71 publications

Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8–A13

Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8–A13

Dietary Approaches to Stop Hypertension (DASH) Score and Its Association with Sleep Quality in a National Survey of Middle-Aged and Older Men and Women

High-Salt Diet Impairs the Neurons Plasticity and the Neurotransmitters-Related Biological Processes

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