High Sensitive C-Reactive Protein (hs-CRP) and Its Correlation with Angiographic Severity of Patient with Coronary Artery Disease (CAD)

Abstract

Severity of CAD was assessed by vessel score, stenosis score and extent score.Result: Significant positive correlation (r=0.7409; p<0.001 r=0.6648; p<0.001 and r=0.6386; p<0.001) Less than 50% of the CAD can be ascribed to traditional risk factors and rests are unexplained. 7 CRP has emerged as the most exquisitely sensitive systemic marker of inflammation and a powerful predictive marker of future cardiovascular risk. Role for inflammation has become well established over the past decade or more in theories describing the atherosclerotic disease process. 8 A body of evidence now suggests that atherosclerosis represents a chronic inflammatory response to vascular injury caused by a variety of agents that activate or injure endothelium and promote lipoprotein infiltration, retention, and modification, combined with inflammatory cell entry, retention and activation. 9 So, from a pathological viewpoint, all stages, i.e., initiation, growth, and complication of the atherosclerotic plaque might be considered to be an inflammatory response to injury. 10,11 Creactive protein (CRP) is one of the acute phase proteins that increase during systemic inflammation. 12 Several prospective studies recently showed that plasma high sensitive Creactive protein (hs-CRP) levels, a more sensitive CRP test, are a powerful predictor of future myocardial infarction and cardiac death among apparently healthy individuals. 13 However, the association between the plasma hs-CRP levels and the severity of coronary stenosis in subjects remains controversial. Some studies previously demonstrated such associations whereas other could not found it. 14,15 This study was performed to determine whether the concentrations of hs-CRP correlate with the coronary atherosclerotic disease assessed by coronary angiography. was found between hs-CRP and vessel score, stenosis score and hs-CRP and extent score suggesting increasing level of hs-CRP strongly suggestive of extensive coronary artery disease. Conclusion: High level of hs-CRP strongly suggestive of extensive coronary artery disease Objectives:General Objective: 1. To correlate the levels of hs-CRP with angiographic severity of coronary artery stenosis in patients with IHD admitted for CAG in DMCH. Correlation between hs CRP with vessel score (n=90).Hs CRP was expressed in mg/L and vessel score ranges from 0 to 3 depending on the number of vessel involve. Significant positive correlations were found between hs-CRP and vessel score.The values of Pearson's correlation coefficient was 0.7409 which is highly significant (p<0.001). Therefore, there was linear positive correlation between hs-CRP and vessel score (Fig. 1). The values of Pearson's correlation coefficient was 0.6648 which is highly significant (p<0.001). Therefore, there was linear positive correlation between hs-CRP and stenosis score (Fig. 2).(p<0.001). Therefore, there was linear positive correlation between hs-CRP and extent score (Fig.-3). DiscussionThis cross sectional study was carried out with an aim to correlate the...

Atherosclerosis Prediction with High Sensitivity C-Reactive Protein (hs-CRP) and Related Risk Factor in Patient with Dyslipidemia

“…Various hypotheses to explain the possible mechanism of which hs-CRP increasing the atherosclerotic risk have been proposed [15] . It has been thought that the development of atherosclerosis was led by serum hs-CRP level [5], [6], [7], [8], [9], [10], [11], [12]. Creactive protein previously has been proposed to correlate with the extent of atherosclerosis [14].…”

“…There for we investigate the possible association between serum hs-CRP with atherosclerosis severity. hs-CRP levels were also shown associated with increased cardiovascular risk [7], [8], [9], [10]. Several new pharmacological approaches have been discovered to reduce hs-CRP levels [11], [12].…”

Blood viscosity increases the degree of coronary stenosis in coronary heart disease

“…The increase in CRP concentration was associated with cardiovascular disease incidence in the future and may predict coronary atherosclerotic disease. (20) Nyandak et al (13) also investigated the relationship between CRP and coronary stenosis by angiography and found a positive correlation; whereas if CRP was correlated with angiographic extent score. The CRP concentration was higher in patients with this angiographic degree of stenosis, showing that CRP concentration was correlated with degree of disease severity in patients with CHD.…”

“…Toth et al (19) found changes in hemorheological parameters in CHD. Hasnat et al (20) concluded that there is an association in patients with CHD between the concentration of highly sensitive C reactive protein (hs-CRP) and CHD severity in comparison to controls. (20) Atherosclerotic plaques, in addition to being a disease of lipid deposition, also have a role in systemic inflammation as their main key, and may be expected to predict the early stages of coronary stenosis.…”

“…Hasnat et al (20) concluded that there is an association in patients with CHD between the concentration of highly sensitive C reactive protein (hs-CRP) and CHD severity in comparison to controls. (20) Atherosclerotic plaques, in addition to being a disease of lipid deposition, also have a role in systemic inflammation as their main key, and may be expected to predict the early stages of coronary stenosis. In view of the above, the objective of the present study was to determine the relationship between blood viscosity as hemorheological parameter and CRP as inflammatory marker in patients with coronary artery stenosis.…”