High-Sensitivity 3D ZIF-8/PDA Photonic Crystal-Based Biosensor for Blood Component Recognition

Abstract

Optical biosensors are sensitive devices used in bioanalytics detection. Analysis of blood constituents is very important for the detection of major diseases and also performs a significant role in the diagnosis of diabetes, various cancers, and cardiovascular disorders. In this work, a three-dimensional photonic crystal-based biosensor composed of zeolitic imidazolate framework-8 (ZIF-8) nanoarrays are placed on polydopamine (PDA) coated on a silicon substrate. This sensor is designed, simulated, and evaluated for various blood components in the wavelength range of 1.1 to 1.5 μm by the finite-difference time-domain (FDTD) method. The proposed biosensor was used for 10 types of blood components such as biotin−streptavidin, bovine serum albumin (BSA), cytop, glucose (40 mg/100 mL), hemoglobin, blood plasma, Sylgard184, white blood compounds, urethane dimethacrylate, and polyacrylamide. The FDTD technique was used for the performance analysis of the biosensor. The design parameters of the radius, the lattice constant, the thickness of the ZIF-8 arrays, and the PDA layer thickness are chosen to optimize the photonic crystal structure. This study indicates that the thickness of the PDA is the most important parameter for peak wavelength value in comparison to the other physical parameters. The factors for optimizing the photonic crystal-based biosensors such as the peak wavelength value (PWV), sensitivity, full width at half-maximum (FWHM), and figure of merit (FOM) are significant in comparison with pertinent works in this field, which evaluated 171 nm/RIU, 7.62 nm, and 22.5 RIU −1 , respectively. A change of 0.01 nm in the refractive index of the constituents of the blood leads to a shift of 80 nm in the maximum peak wavelength, therefore acting as a functional biosensor with a high detection limit of 0.004 RIU.

Zeolites: A series of promising biomaterials in bone tissue engineering

“…The advantages in microporosity, large surface area, rich structural variety, and high chemical and thermal stability make it broadly used ( Lin et al, 2019 ; Chen et al, 2020 ; Ozyilmaz et al, 2022 ). The majority of MOFs either contain cytotoxic elements such as chromium ( Karimi-Maleh et al, 2021 ) or are synthesized using non-acquire based methods, whereas ZIF-8 thin film can be synthesized using acquire based methods ( Mohammad et al, 2020 ; Yang et al, 2020 ; Fardjahromi et al, 2021 ; Nankali et al, 2021 ). Furthermore, because of its benign production conditions and high biocompatibility, ZIF-8 is widely regarded as one of the most preferred MOFs for biomedical applications ( Ricco et al, 2018 ; Feng et al, 2019 ).…”

Metal–organic framework-based photonic crystal platforms for gas sensing: a review

“…87,88 Their unique characters such as photon localization make them rapidly evolve in the field of physics, chemistry, biology, materials science, nanotechnology, etc. [89][90][91][92] Compared with 1-D and 3-D PC sensors, 2-D PC sensors required a small amount of different materials and a thin overall structure, result in excellent sensitivity and response. 52 Thus, it is significant to prepare 2-D PCs for the design of outstanding-performance MOF-based 2-D PC gas sensors.…”

Active Optical Signal Conditioning and Monitoring System

“…Due to the diffraction of light at the collapse region and insertion losses 37 there is a finite decrease in transmitted power. However, the transmitted spectrum is stable, temperature tolerant, and acts as a guiding spectrum for sensing applications [38][39][40][41][42] .…”