High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension

Wasilewska, Anna; Tenderenda, Edyta; Taranta-Janusz, Katarzyna; Zoch-Zwierz, W

doi:10.1007/s00467-010-1513-2

Cited by 13 publications

(11 citation statements)

References 52 publications

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“…In pediatric subjects with prehypertension and hypertension, Wasilewska et al demonstrated a strong positive correlation between MPV and UA. Using linear regression analysis, they showed that an increase of 1 mg/dL in UA levels was associated with an average increase of 0.27 fL in MPV [23]. In patients with nonalcoholic fatty liver disease, Shin et al also reported a positive correlation between MPV and UA [24].…”

Section: Discussionmentioning

confidence: 93%

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

et al. 2013

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Mean platelet volume (MPV) can reflect platelet activity. Furthermore, high MPV is associated with thrombogenic activation and increased risk of cardiovascular disease. MPV of subjects with hypertension, hyperglycemia, or hyperlipidemia is higher compared with that of normal subjects. In contrast, the relationship between MPV and uric acid (UA) is poorly understood. The present study aims to evaluate the relationship between MPV and serum UA levels in both genders. We retrospectively studied 2104 Japanese subjects (1221 males, 883 females) undergoing general health examinations. Age, gender, body mass index (BMI), blood pressure (BP), smoking habits, alcohol intake, lipid profiles, fasting plasma glucose (FPG), high-sensitivity C-reactive protein, serum UA levels and MPV were evaluated. On the basis of the serum UA levels, the subjects were categorized into the following tertiles: 1st (Q1), 2nd (Q2), and 3rd (Q3). In males, a univariate analysis revealed that age, FPG and systolic and diastolic BP were significantly associated with MPV; in addition to these parameters, in females, UA and LDL-cholesterol correlate with MPV. Furthermore, in females, a stepwise linear regression analysis showed a significant positive correlation between UA and MPV (β=0.059, p=0.008). MPV in females increased gradually based on the serum UA tertile, despite adjusting for confounding variables (Q1, Q2, and Q3 values were 9.88 ± 0.70, 9.95 ± 0.73, and 10.00 ± 0.77 fL, respectively; p<0.039). The serum UA levels were found to be a key determinant of MPV in females.

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Section: Discussionmentioning

confidence: 93%

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

et al. 2013

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“…Another interesting finding was the negative correlation between MPV and plasma lipid levels, which is considered a major cardiovascular risk factor. Although several studies have previously shown the association between MPV and hypertension, 14,15,21,22 its relationship in subjects without hypertension is unknown. The latest studies have shown that prehypertension causes platelet activation, as demonstrated by increased MPV.…”

Section: Discussionmentioning

confidence: 96%

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

et al. 2012

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Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with hypertension. However, data available on the association between MPV level and prehypertension are limited. Prehypertension is also associated with an increase in cardiovascular morbidity and mortality. A cross-sectional study was performed among 80 545 standardized medical checkup participants X18 years in age without hypertension or diabetes in China between April 2009 and May 2010. Blood pressure was categorized as prehypertensive (systolic blood pressure, 120-140 mm Hg and/or diastolic blood pressure, 80 to 90 mm Hg, n ¼ 36 586) and normotensive (systolic blood pressure, o120 mm Hg and diastolic blood pressure, o80 mm Hg, n ¼ 43 959). Mean systolic blood pressure and the prevalence of prehypertension increased significantly with increasing MPV. After adjusting for demographics, body mass index, smoking and serum cholesterol, the odds ratio for prehypertension, when comparing the highest category of MPV (412.0 fl) with the lowest category (o10.1 fl), was 1.08 (95% confidence interval, 1.02-1.13; P for trend ¼ 0.014). This association persisted in separate analysis among men but not among women. In nonparametric models, the positive association between MPV and prehypertension appeared to be present across the full range of MPV, without any threshold effect. Increased MPV is associated with prehypertension in a large sample of Chinese adults that are free of cardiovascular disease and hypertension.

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“…In addition, recent studies have showed that platelet depletion resulted in a significant inhibition of allergen-induced airway hyperresponsiveness, and it was found to be more effective in suppressing airway remodeling processes than the administration of a glucocorticosteroid [47]. Previous studies showed that there were no changes in MPV levels and no negative associations between MPV and CRP in asthmatic children [21], but a genome-wide association study revealed that there are different mechanisms in childhood asthma and adult asthma [48,49,50,51]. Further investigations on the role of activated platelets in asthma may be beneficial in the search for therapeutic targets.…”

Section: Discussionmentioning

confidence: 99%

A Decreased Mean Platelet Volume Is Associated with Stable and Exacerbated Asthma

Sun¹,

Zhang

Cao³

et al. 2014

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Background: Systemic inflammation is related to disease progression in asthma. Activated platelets play a critical role in atherogenesis, inflammation, and atherothrombosis. The mean platelet volume (MPV) is an early marker of platelet activation. Objectives: The aim of this study is to clarify the relevance of MPV levels in patients with stable and exacerbated asthma. Methods: We investigated the peripheral blood cell count parameters, C-reactive protein (CRP), lung function parameters, and arterial blood gas in patients with asthma and control subjects. Eighty-five stable asthma patients and 85 asthmatics with exacerbations were investigated. Eighty-five controls matched for age, gender, body mass index (BMI), and smoking status were recruited. Results: Patients with exacerbated asthma had lower MPV and higher CRP levels and white blood cell (WBC) counts compared to patients with stable asthma and control subjects. Furthermore, the MPV was reduced in patients with stable asthma compared to control subjects. Negative correlations between MPV and CRP were present in stable and exacerbated asthma. Although there was no relationship between MPV and WBC count in stable asthma, there was an inverse relationship between MPV and WBC count in exacerbated asthma. Conclusions: These findings show that patients with stable asthma had a lower MPV compared to controls and the MPV levels in asthmatic patients with exacerbations were lower compared to those in patients with stable asthma. Further investigations regarding the role of MPV in asthma may be beneficial in the search for therapeutic targets.

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High-sensitivity C-reactive protein and mean platelet volume in paediatric hypertension

Cited by 13 publications

References 52 publications

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Gender differences in the relationship between serum uric acid and mean platelet volume in a Japanese general population

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

A Decreased Mean Platelet Volume Is Associated with Stable and Exacerbated Asthma

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