High-sensitivity C-reactive protein is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients

Anan, Futoshi; Takahashi, Naohiko; Nakagawa, Mikiko; Ooie, Tatsuhiko; Saikawa, Tetsunori; Yoshimatsu, Hironobu

doi:10.1016/j.metabol.2004.11.012

Cited by 62 publications

(47 citation statements)

References 31 publications

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“…Olumide Olatubosun Rowaiye et al, Baroreceptor sensitivity and diabetes mellitus -The presence of low-grade inflammation (higher levels of plasma high-sensitivity C-reactive protein (hsCRP) [54]: In type 2 DM patients, increased plasma levels of hsCRP have been associated with depressed cardiovascular autonomic function as indicated by diminished BRS [54]. Higher plasma levels of CRP have also been linked to insulin resistance, obesity (increased body mass index) and the development of type 2 DM, thereby suggesting the role of an underlying inflammatory process in the etiopathogenesis of diabetes [55][56][57].…”

Section: Features Clinical and Prognostic Consequences Of Diminishedmentioning

confidence: 99%

Baroreceptor sensitivity and diabetes mellitus

Rowaiye

Jankowska²,

Ponikowska³

2013

Cardiol J

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Section: Features Clinical and Prognostic Consequences Of Diminishedmentioning

confidence: 99%

Baroreceptor sensitivity and diabetes mellitus

Rowaiye

Jankowska²,

Ponikowska³

2013

Cardiol J

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“…Although plasma CRP is reported to be associated with insulin resistance in type 2 diabetic patients (11,12), the significance of HSCRP in diabetic aortic stiffness has not been adequately investigated.…”

Section: Introductionmentioning

confidence: 99%

Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients

et al. 2007

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Background: The elevated level of high-sensitivity C-reactive protein (HSCRP) and aortic stiffness are associated with high mortality in type 2 diabetic patients. We tested the hypothesis that the HSCRP correlates with aortic stiffness and insulin resistance in type 2 diabetic patients. Material and methods: The study consisted of 46 Japanese patients with type 2 diabetes and high HSCRP group (0.3-1.0 mg/dl, age: 57G5 years, meanGS.D.) and a control group of 55 age-matched patients with low HSCRP group (!0.3 mg/dl, 57G6 years). Brachial-ankle pulse wave velocity (BaPWV) was measured by automatic oscillometric method and was used as an index of atherosclerosis. Results: The body mass index (BMI) values (P!0.05) and waist circumferences (P!0.0005) and the waist-to-hip ratios (P!0.05) were higher in the high HSCRP group than in the low HSCRP group. The BaPWV was higher in the high HSCRP group than in the low HSCRP group (P!0.0001). Fasting plasma glucose (FPG; P!0.005) and insulin concentrations (P!0.0001), and the homeostasis model assessment (HOMA) index (P!0.0001), were higher in the high HSCRP group than in the low HSCRP group. Multiple regression analysis showed that HSCRP levels were independently predicted by BaPWV and HOMA index. Conclusions: Our results indicate that the elevated level of HSCRP in Japanese patients with type 2 diabetes is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV and HOMA index are independent predictors of HSCRP.

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“…• BMI (p = 0.04, 95%CI 0.001 -0.058), WC (p = 0.030, 95%CI 0.002-0.035), TG (p = 0.001, 95% CI 0.001 -0.004) These could be surrogate clinical markers of insulin resistance 5 .…”

Section: Discussionmentioning

confidence: 99%

Anthropometric and Biochemical Markers of Insulin Resistance

2016

IJSR

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Abstract:. Insulin resistance is associated with obesity, impaired glucose tolerance (IGT) and type 2 diabetes mellitus, predisposing to adverse cardiovascular outcomes and cerebrovascular disease. This makes it important to identify persons with increased insulin resistance as they are at high risk of vascular problems and related morbidity and mortality. This study was done to assess noninvasive markers of insulin resistance used in routine clinical practice such as anthropometry, lipid profile and hsCRP and to determine their correlation with insulin resistance. A cross-sectional study including 90 subjects was conducted. Each participant underwent anthropometric assessment including BMI, Waist and Hip circumference measurements, fasting insulin, fasting glucose, fasting lipid profile and hsCRP measurements. Statistical Analysis was done using SPSS version 15 and results analyzed by spearman's correlation coefficient. Linear regression analysis was done to find the relation between HOMA-IR, anthropometry and lipid profile.BMI, waist circumference and serum triglyceride levels showed significant correlation with log HOMA-IR indicating that they are significant noninvasive markers of insulin resistance. Hence simple anthropometry and routine biochemical investigations done as standard care can be used to identify patients with insulin resistance. Appropriate remedial life style and other measures can be used in these patients to avoid adverse vascular outcomes.

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High-sensitivity C-reactive protein is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients

Cited by 62 publications

References 31 publications

Baroreceptor sensitivity and diabetes mellitus

Baroreceptor sensitivity and diabetes mellitus

Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients

Anthropometric and Biochemical Markers of Insulin Resistance

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