“…The development of optical sensors for the detection of bioaffinity reactions has been of strong interest in the past decades. Besides cost reduction, many of these efforts were made to reduce the preparation steps involved, for example, by using label-free detection of analytes, − or to lower the detection limits by using chemical amplification schemes. − In addition, various physical principles have been further developed such as total internal reflection, surface plasmon resonance, or resonance light scattering − in order to increase the sensitivity and to lower the detection limits. However, although many of these new optical sensors have shown excellent performance for specific applications, the technical requirements/costs are high and the throughput is limited.…”