High Seropositivity of Japanese Homosexual Men for Amebic Infection

Takeuchi, Tsutomu; Okuzawa, Eiichi; Nozaki, Tomoyoshi; Kobayashi, Seiki; Mizokami, M.; Minoshima, Nobutoshi; Yamamoto, Masahiko; Isomura, Shin

doi:10.1093/infdis/159.4.808

Cited by 54 publications

(34 citation statements)

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“…[1][2][3][8][9][10]14,27,28 The specific reason(s) for the observed gender difference in the Japanese surveillance data requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…7 Recent studies have reported that invasive amebiasis is prevalent not only in developing countries due to contaminated food or water, but also in developed areas of east Asia (e.g., China, Japan, Korea, and Taiwan) and Australia as a sexually transmitted infection via oral-anal sexual contact, particularly among men who have sex with men (MSM). [8][9][10] Amebiasis is a nationally notifiable disease in Japan, which is one of the few places, along with Taiwan, to conduct national surveillance for amebiasis. 11 Physicians are required to report all cases of amebiasis to the National Epidemiological Surveillance of Infectious Diseases (NESID) system in Japan within 7 days of case diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of Domestically Acquired Amebiasis in Japan, 2000–2013

Ishikane¹,

Arima²,

Kanayama³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Notifications of amebiasis have been increasing in Japan. Using national surveillance data during 2000-2013, reported cases of amebiasis were analyzed. A case of amebiasis was defined as laboratory-confirmed Entamoeba histolytica infection, regardless of presence of symptoms. We described temporal trends and analyzed correlates of asymptomatic versus symptomatic cases based on odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression. Of 9,946 cases reported during 2000-2013, 7,403 were domestic cases. During this period, the proportion of domestic cases increased from 63% to 85%. Among male cases, majority were middle aged, and from 2008, the number of cases attributed to heterosexual contact surpassed that of homosexual contact. During 2010-2013, increase in notifications was associated with asymptomatic cases, colonoscopy diagnosis, and males with unknown or heterosexual route of infection. Among males, colonoscopy (OR = 31.5; 95% CI = 14.0-71.0) and cases with unknown route of infection, relative to homosexual contact (OR = 2.2; 95% CI = 1.3-3.9), were associated with asymptomatic infections in multivariate analysis. Although the recent rise may have been due to enhanced detection by colonoscopy or reporting, the large number of asymptomatic cases, with reportedly unknown or heterosexual route of infection, has led to a better understanding of amebiasis in Japan and highlights the potential public health concern.

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“…[1][2][3][8][9][10]14,27,28 The specific reason(s) for the observed gender difference in the Japanese surveillance data requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of Domestically Acquired Amebiasis in Japan, 2000–2013

Ishikane¹,

Arima²,

Kanayama³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…In large cities of developed countries, amebiasis is commonly found within two closed communities; in homosexual men (1)(2)(3) and in mental hospitals (4). The disease seems to be more common in institutions for the mentally retarded, because they exhibit frequently abnormal hand-to-mouth and object-to-mouth behavior.…”

Section: Introductionmentioning

confidence: 99%

Amebiasis in Institutions for the Mentally Retarded in Kanagawa Prefecture, Japan

Nagakura

Tachibana

Kaneda

et al. 1990

JJMSB

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SUMMARY:A parasitologic survey of 620 mentally retarded patients, institutionalized in five different facilities in Kanagawa Prefecture, revealed a high incidence (12.6%) of infection with Entamoeba histolytica. A concomitant serologic survey, by the indirect fluorescent antibody test, gave a much higher incidence (26.5%). Moreover, most zymodeme patterns of the amebae isolated from infected individuals were of a pathogenic type (Zymodeme II). Our findings demonstrate that the mentally retarded in Japan, as in the United States, still are plagued by a high rate of amebic infection.

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“…Takeuchi et al reported that the ELISAtest for amebic antibodies was highly positive (13.4-20.4%) in Japanese homosexual men (9). Previous reports have shown many invasive amebiasis in Japanese homosexual men (10)(11)(12).…”

Section: Discussionmentioning

confidence: 97%

Amebiasis in Japanese Homosexual Men with Human Immunodeficiency Virus Infection.

et al. 2001

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Wereport cases of amebiasis in 6 human immunodeficiency virus (HlV)-positive male patients. Five were confirmed homosexualswhile one was suspected. Three patients had liver abscess and 5 had colitis with duration of 10 days to months. The patients with liver abscess showeda lower incidence of abdominal pain but a higher incidence of concomitant diarrhea. Drainage therapy was effective for rapid afebrile results. Twoinvasive colitis cases died from perforation. This may have been due to delayed diagnosis. Invasive amebiasis is not commoneven in HIV-infected individuals. AmongJapanese homosexual men, however, it may cause symptomatic diseases. (Internal Medicine 40: 671-675, 2001)

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High Seropositivity of Japanese Homosexual Men for Amebic Infection

Cited by 54 publications

References 0 publications

Epidemiology of Domestically Acquired Amebiasis in Japan, 2000–2013

Epidemiology of Domestically Acquired Amebiasis in Japan, 2000–2013

Amebiasis in Institutions for the Mentally Retarded in Kanagawa Prefecture, Japan

Amebiasis in Japanese Homosexual Men with Human Immunodeficiency Virus Infection.

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