High Seroprevalence Against Lawsonia intracellularis Among Adult Horses in Belgium

Loublier, Clémence; Cerri, Simona; Gryspeerdt, Annick; Amory, Hélène; Bauwens, Caroline; Cesarini, Carla

doi:10.1016/j.jevs.2020.103304

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Contrary to serology, the younger age was associated with the PCR positivity; 3 % in <2 years, 25 % in 2-5 years, 13 % in 6-10 years and 8 % in >10 years (11). A recent study in Belgium also demonstrated 98.8% seropositivity by bELISA and confirmed high seropositivity rates in adult horses (mean age 12.1 years) (9). It is evident that exposure of horses to L. intracellularis increases by age (11).…”

Section: Discussionmentioning

confidence: 68%

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Molecular and serological investigation of Lawsonia intracellularis in weanling foals in Türkiye

Metiner

Mete²,

Erol

2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Equine proliferative enteropathy caused by Lawsonia intracellularis has been described in weanlings in many different countries including the USA, Western Europe, Israel, Korea and Brazil but not investigated in Turkey and Eastern Europe. The objective of the study was to determine the seroprevalence and fecal shedding of L. intracellularis in weanling foals. A cross-sectional study was designed in randomly selected 97 weanling foals with or without clinical signs from 3 different provinces of Turkey. Total protein and albumin levels in serum samples from 97 foals were measured using automated biochemistry analyser. Serum samples and fecal samples were also tested by bELISA and real-time PCR to detect L. intracellularis-specific antibodies and -DNA, respectively. Seropositivity was found to be 25.8% by bELISA. However, none of the fecal samples were positive by real-time PCR. Statistically, no significant associations were found between seropositivity and clinical signs or serum ALB/TP levels. Seropositivity indicated the exposure of weanling foal population to L. intracellularis for the first time in Turkey. Further investigations are needed to better understand the epidemiology of the disease in the weanlings as well as adult horse populations and potential wildlife resorvoirs in the country/region.

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Section: Discussionmentioning

confidence: 68%

“…The same bELISA kit was also used in foals and adult horses in earlier studies (8,9,11). In a previous study, the authors compared the bELISA with immunoperoxidase monolayer assay (IPMA), as a reference test, for the detection of antibodies against L. intracellularis in horses.…”

Section: Discussionmentioning

confidence: 99%

Molecular and serological investigation of Lawsonia intracellularis in weanling foals in Türkiye

Metiner

Mete²,

Erol

2023

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…The prevalence of L. intracellularis shedding in pig feces was found to be 26.5% in European countries ( 39 ), 19.9% in South Korea ( 45 ), 65.7% at the herd level in Poland ( 46 ), and 46%−57% among slaughter-age pigs in the Netherlands ( 43 ). In horses, the seroprevalence of antibodies to L. intracellularis was reported to be 98.8% among adult horses in Belgium ( 47 ), and Kranenburg et al previously demonstrated that the prevalence of L. intracellulari antibodies in foals increased significantly from 15% before weaning to 23% after weaning; it was 89% in yearlings and 99% in horses older than 2 years ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated risk factors for Lawsonia intracellularis infection in farmed rabbits: A serological and molecular cross-sectional study in South Korea

Yeh

2023

Front. Vet. Sci.

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Lawsonia intracellularis is the etiological agent of proliferative enteropathy, which is globally considered an important enteric disease in pigs and horses. Experimental studies suggest that the organism spreads by subclinical infection of many animals, including rabbits. Despite the importance of rabbits in the epidemiology of L. intracellularis, the extent of exposure to L. intracellularis in the rabbit population is poorly defined and remains unclear. The objective of this cross-sectional study was to investigate the seroprevalence and shedding of L. intracellularis in farmed rabbits. Furthermore, we aimed to identify risk factors associated with seropositivity. Sera from the rabbits were used to measure L. intracellularis-specific antibodies by immunoperoxidase monolayer assay, and rectal swabs were used to detect L. intracellularis DNA using a real-time PCR assay. Antibodies against L. intracellularis were detected in 12.3% of farms (20/163) and 6.3% of rabbits (49/774). Lawsonia intracellularis DNA in rectal swabs was detected in 3.8% of farms (6/156) and 1.2% of rabbits (8/667). The risk factor analysis showed that the presence of pigs or horses on the farm or the neighboring farm was associated with an increase in the risk of seropositivity (p < 0.05). We observed significantly increased odds of positivity for L. intracellularis in rabbits with a history of digestive trouble (diarrhea) on the farm during the 3 months before the samples were obtained (p < 0.05). Collectively, these findings demonstrated that L. intracellularis infection was evident among farmed rabbits and that rabbits might serve as an important reservoir for L. intracellularis epidemiology.

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“…Etkene bağlı hastalıklar ilk tespit edildiğinden bugüne kadar sporadik olgular ve salgınlar şeklinde birçok kez raporlanmıştır. Son yıllarda da sıklıkla sütten yeni kesilen taylar başta olmak üzere ara sıra erişkin atlarda raporlanan bir hastalık olarak, Amerika Birleşik Devletleri (ABD), Kanada, Brazilya, Japonya, Güney Kore ve Türkiye dahil olmak üzere Avrupa'da raporlanmış ve dünya çapında bir yaygınlığa ulaştığı görülmüştür (3,5,(6)(7)(8)(9)(10).…”

Section: Etiyolojiunclassified

Lawsonia Intracellularis as an Enteric Pathogen in Horses

METE

2023

Bozok Veterinary Sciences

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Proliferatif enteropati (PE) zorunlu hücre içi bakteri türü olan Lawsonia intracellularis tarafından oluşturulan özellikle 1 yaş altındaki taylarda şiddetli klinik bulgularla, 1 yaş üstü atlarda da genellikle asemptomatik olarak, nadiren de klinik bulgularla izleyebilen bir hastalıktır. Etken bulaşması semptomatik ve/veya asemptomatik taylardan ve erişkin atlardan fekal-oral yolla olabileceği gibi domuz, kedi, köpek, tavşan, keseli sıçangiller, kokarca, fare, çakal gibi evcil ve vahşi hayvanların da rezervuar görevi üstlenerek etkenin saçılmasında ve bulaştırılmasında rol oynayabilmektedir. Hastalıkta klinik bulgular olarak yüksek ateş, letarji, periferal ödem, ishal, kolik, kilo kaybı ve buna bağlı gelişme geriliği gibi bulgular görülmektedir. Teşhiste, klinik bulgularla birlikte hipoproteinemi, ultrason muayenesinde ince bağırsak duvarında kalınlaşma görülmesi, pozitif seroloji ve etkenin dışkıda moleküler yöntemlerle tespiti gibi yöntemler kullanılmaktadır. Antimikrobiyal tedavide genellikle makrolid grupları antibiyotikler olmak üzere bunların rifampin, kloramfenikol, oksitetrasiklin ve doksisilin kombinasyonları kullanılmaktadır. Hastalığın endemik görüldüğü tesislerde tayların klinik bulgular yönünden izlenmesi, belirli periyotlarda serum protein ve albümin seviyelerin ölçülmesi ve serolojik yoklamaların yapılması korunma ve kontrol önlemleri kapsamında önemlidir. Bu derleme makalesi ile L. intracellularis’in etiyolojik özellikleri ile etkenin neden olduğu hastalığın epidemiyolojisi, patogenezi, klinik bulguları, teşhiste kullanılan metotlar, tedavi yöntemleri ile korunma ve kontrol tedbirleri hakkında bilgi sunulması amaçlanmıştır.

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High Seroprevalence Against Lawsonia intracellularis Among Adult Horses in Belgium

Cited by 4 publications

References 25 publications

Molecular and serological investigation of Lawsonia intracellularis in weanling foals in Türkiye

Molecular and serological investigation of Lawsonia intracellularis in weanling foals in Türkiye

Prevalence and associated risk factors for Lawsonia intracellularis infection in farmed rabbits: A serological and molecular cross-sectional study in South Korea

Lawsonia Intracellularis as an Enteric Pathogen in Horses

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