High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes

Filardi, Tiziana; Carnevale, Vincenzo; Massoud, Renato; Russo, Carmelo; Nieddu, Luciano; Tavaglione, Federica; Turinese, Irene; Lenzi, Andrea; Romagnoli, Elisabetta

doi:10.1007/s40618-018-0914-0

Cited by 17 publications

(15 citation statements)

References 28 publications

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“…For OPG we measured increased serum levels, which confirms a finding by Ostrowska et al [26], although in patients with AN an increased secretion of RANKL, and decreased levels would be expected due to estrogen deficiency [27]. Osteopontin (OPN) is a non-collagenous matrix protein expressed in bone tissue, which is involved in bone remodeling and capable of activating bone resorption [28]. Osteopontin has been associated with increased fracture risk in postmenopausal women, but previous reports on serum levels in subjects with AN are lacking.…”

Section: Discussionsupporting

confidence: 82%

Modestly degraded microarchitecture and high serum levels of osteopontin in Swedish females with anorexia nervosa

et al. 2020

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Purpose Adult women with long-time anorexia nervosa (AN) are believed to have osteopenia (T-score ≤ 1.0) in 93 % and osteoporosis (T-score ≤ 2.5) in 38 %. Bone microarchitecture assessed by Trabecular Bone Score (TBS) predicts osteoporotic fractures. Our aim was to evaluate the microarchitecture in adult females with AN by determining TBS and to identify factors potentially associated with TBS, such as bone turnover markers. Methods 20 female patients with AN (DSM IV), aged 27.8 ± 4.4 years, BMI 16.6 ± 0.6 kg/m2 and duration of illness of 8.5 ± 5 years had previously been evaluated with dual-energy X-ray absorptiometry (DXA). TBS measurements were now obtained, using iNsight software, from spinal DXA images. Serum levels of bone turnover markers were determined in patients and healthy normal-weight controls. Results Compared to controls serum values of osteopontin were higher (p = 0.009). BMD in patients with AN was reduced by at least 1.0 SD at one or more skeletal sites in 65 % of patients and by at least 2.5 SD in 20 %. Only one of the patients (5%) had suffered a fracture. TBS (mean 1.35 ± 0.06; median 1.36 (1.23–1.44) was in the lower normal range (≥ 1.35). 40 % of patients showed partially (> 1.20 and < 1.35) but none showed a fully degraded micro-architecture. Conclusions In Swedish AN patients we found a low reduction of BMD and fracture history. The bone microarchitecture, evaluated for the first time for this group by TBS, was only modestly compromised, and to a lesser extent than expected for this group of patients with AN. Level of evidence Level V; cross-sectional descriptive study.

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Section: Discussionsupporting

confidence: 82%

Modestly degraded microarchitecture and high serum levels of osteopontin in Swedish females with anorexia nervosa

et al. 2020

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“…Circulating levels of insulin like-growth factor-1 (IGF-1) have also been associated with an increased fracture risk [ 102 104 ], both with prevalent vertebral fractures [ 102 ] and incident fractures [ 104 ]. Also, circulating levels of osteopontin and osteoglycin have been associated with prevalent vertebral fractures and may be novel fracture predictors in T2D [ 105 106 ]. Future fracture predictors in T2D may be measurable in blood; however, further research is needed and until such fracture predictors are established, BMD continue to be the best fracture predictor available.…”

Section: Detection Of Diabetic Bone Diseasementioning

confidence: 99%

Skeletal Fragility in Type 2 Diabetes Mellitus

2018

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Type 2 diabetes (T2D) is associated with an increased risk of fracture, which has been reported in several epidemiological studies. However, bone mineral density in T2D is increased and underestimates the fracture risk. Common risk factors for fracture do not fully explain the increased fracture risk observed in patients with T2D. We propose that the pathogenesis of increased fracture risk in T2D is due to low bone turnover caused by osteocyte dysfunction resulting in bone microcracks and fractures. Increased levels of sclerostin may mediate the low bone turnover and may be a novel marker of increased fracture risk, although further research is needed. An impaired incretin response in T2D may also affect bone turnover. Accumulation of advanced glycosylation endproducts may also impair bone strength. Concerning antidiabetic medication, the glitazones are detrimental to bone health and associated with increased fracture risk, and the sulphonylureas may increase fracture risk by causing hypoglycemia. So far, the results on the effect of other antidiabetics are ambiguous. No specific guideline for the management of bone disease in T2D is available and current evidence on the effects of antiosteoporotic medication in T2D is sparse. The aim of this review is to collate current evidence of the pathogenesis, detection and treatment of diabetic bone disease.

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“…Our ELISA results showed significantly higher serum levels of OPN and β‐CTX in hip fracture in the elderly compared to healthy controls. Previous studies have shown that a high serum level of OPN results in increased fracture and a worse lipid profile in postmenopausal women with type 2 diabetes . Higher serum levels of OPN are observed in patients with OP and are correlated with the decline of BMD, increase of bone turnover markers, and osteoporotic vertebral fractures .…”

Section: Discussionmentioning

confidence: 95%

“…A recent study reported that OPN is overexpressed in idiopathic hip osteoarthritis and promotes its development . In addition, another study concluded that increased serum levels of OPN are correlated with prevalent fractures in postmenopausal women with type 2 diabetes . As a member of the carboxy‐terminal cross‐linking telopeptide of type I collagen (CTX) family, β‐CTX has been confirmed as a significant marker in bone resorption and formation .…”

Section: Introductionmentioning

confidence: 99%

The increase of osteopontin and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen enhances the risk of hip fracture in the elderly

Lin

Liu

et al. 2020

Clinical Laboratory Analysis

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Background: Hip fracture in the elderly is a health burden worldwide due to its high mortality rate. This study was conducted to determine the possible mechanisms of osteopontin (OPN) and β-carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX) in hip fracture in the elderly. Materials and Methods:In the study, we recruited 108 elderly patients with hip fracture diagnosed from May 2012 to May 2015 at the Third Hospital of Xiamen and 86 healthy individuals without a history of hip fracture were taken as controls. Serum levels of OPN and β-CTX were then determined. The T and Z values for bone mineral density (BMD) were also measured. Moreover, logistic regression analysis was performed to assess the risk and protective factors for hip fracture in the elderly.Results: Serum levels of both OPN and β-CTX were increased in elderly patients with hip fracture. OPN was positively correlated with β-CTX. In addition, the levels of OPN and β-CTX shared a positive association with the age, and a negative association with the BMD, in terms of T and Z values of the hip. In addition, increased BMD and outdoor sports might be protective factors for hip fracture, and an increase in levels of OPN and β-CTX might be associated with a higher risk of hip fracture in the elderly population. Discussion:Collectively, increased serum levels of OPN and β-CTX might be correlated with a higher risk of a hip fracture and have predictive values in the occurrence of hip fracture in the elderly. K E Y W O R D Sbone mineral density, hip fracture in the elderly, osteopontin, β-carboxy-terminal cross-linking telopeptide of type I collagen

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High serum osteopontin levels are associated with prevalent fractures and worse lipid profile in post-menopausal women with type 2 diabetes

Abstract: In post-menopausal women with T2DM, OPN might be a useful marker of fracture and worse lipid profile.

Cited by 17 publications

References 28 publications

Modestly degraded microarchitecture and high serum levels of osteopontin in Swedish females with anorexia nervosa

Modestly degraded microarchitecture and high serum levels of osteopontin in Swedish females with anorexia nervosa

Skeletal Fragility in Type 2 Diabetes Mellitus

The increase of osteopontin and β‐carboxy‐terminal cross‐linking telopeptide of type I collagen enhances the risk of hip fracture in the elderly

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