High Spatiotemporal Control of Spontaneous Reactions Using Ultrasound-Triggered Composite Droplets

Abstract

Achieving high spatial and temporal control over a spontaneous reaction is a particularly challenging task with potential breakthroughs in various fields of research including surface patterning and drug delivery. We report here an exceptionally effective method that allows attaining such control. This method relies on a remotely triggered ultrasound-induced release of a reactant encapsulated in a composite microdroplet of liquid perfluorohexane. More specifically, the demonstration was achieved by locally applying a focused 2.25 MHz transducer onto a microfluidic channel in which were injected composite microdroplets containing a solution of an azidocoumarin and an external flow containing a reactive alkyne.

Sequential release of nanoparticle payloads from ultrasonically burstable capsules

“…The maintenance of cell viability and tissue temperatures observed here are consistent with other reports in that the ultrasonic exposures utilized here are well below those determined to be harmful to cells [51,52]. Finally, in other more sensitive applications, improved targeting of these capsules can potentially be achieved through the use of high intensity focused ultrasound [53,54]. …”

Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies

“…Here, chemotherapeutic agents are encapsulated into TSLs so that the drug can be selectively released at elevated temperatures when passing through a locally heated tumor. The concept of hyperthermia-triggered drug delivery using TSLs, as proposed by Yatvin and Weinstein [195], has been evaluated in preclinical models with various heat sources, such as needle-based radiofrequency (RF), water baths, light sources, and catheters [196][197][198][199]. Recently, multiple preclinical studies have been published showing HIFU-induced drug delivery in mice, rats and rabbits [172,174,200,201].…”

Magnetoresponsive Virus‐Mimetic Nanocapsules with Dual Heat‐Triggered Sequential‐Infected Multiple Drug‐Delivery Approach for Combinatorial Tumor Therapy

“…Jen-Hung Fang , Yun-Ting Lee , Wen-Hsuan Chiang , and Shang-Hsiu Hu * such as pH, [3][4][5] light, [6][7][8] temperature, [ 9 ] redox potential, [ 10 ] ultrasound, [ 11,12 ] or magnetic fi eld (MF). [ 13,14 ] Despite the improved therapeutic effi ciency, most of these nanoparticles usually attach on the cancerous cells of tumor periphery near the blood vessels, thus leading to humble survival benefi ts.…”