Comparator is a very useful combinational logic circuit. In this paper performance analysis of CMOS Comparator and PTL logic design has been shown. In the design of integrated circuits, several logic families is being used which is described by Pass Transistor Logic (PTL). It reduces the count of transistors used to make different logic gates, by eliminating redundant transistors. The layout of 2-bit comparator is developed using automatic and semi-custom techniques. Both the layouts are compared and analyzed in terms of their area consumption. Automatic layout is generated from its equivalent schematic whereas semi-custom layout is optimized manually. The result shows that semicustom layout of PTL logic consumes 35% less area as compared to CMOS logic design to provide area efficient solution.