High-speed CMOS image sensor for high-throughput lensless microfluidic imaging system

Yan, Mei; Huang, Xiwei; Jia, Qixiang; Nadipalli, Revanth; Wang, Tongxi; Shang, Yang; Yu, Hao; Je, Minkyu; Yeo, Kiat Seng

doi:10.1117/12.911962

Cited by 11 publications

(10 citation statements)

References 10 publications

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“…The specimen was moved inside the microfluidic channel using gravity while CMOS image sensors captured red‐green‐blue (RGB) images to obtain a final colored image. Wang et al and Yan et al further demonstrated high (4×) resolution and lensless imaging system using CMOS image sensors that are able to detect smaller fast moving bioparticles flowing in a microfluidic channel by achieving a resolution of as much as 0.25 µm at a frame rate of 1750–6000 frames s −1 …”

Section: Role Of Cmos In Microfluidicsmentioning

confidence: 99%

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

et al. 2018

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additional parts, such as syringe pumps, control valves, and microscopes, which not only increase the complexity and cost of the system but also create a dependence of the system on a laboratorybased environment. Technology has now advanced so much that there are fully integrated sample-in-results-out chips for genetic analysis, [8] sensors that can detect a handful of molecules, and many other similar systems. [9] Complementary metal oxide semiconductor (CMOS) integrated LOC systems can be developed using CMOS technologies as sensors, signal conditioners, data processing circuitry, actuators, and wireless communication capabilities. [10][11][12][13][14][15][16][17] CMOS is a set of microfabrication and nanofabrication processes, which is used to manufacture semiconductor chips present inside computer, smartphone, or any electronic gadgets. Consequently, these chips are referred to as CMOS enabled or CMOS based chips. CMOS based chips can act as a processor, memory, and digital logic circuitry for data management. In this review, we will discuss how CMOS based devices have enabled both management of data from microfluidic devices as well as sensors and actuators to help complement the functionality of LOC devices. CMOS logics are simple to make, and consume little to no current in idle state. With the advancements in Moore's law we have seen the size of CMOS devices getting smaller and smaller allowing for more functionality to fit in a smaller area. [18] CMOS plays a significant role in the realization of portable and versatile microfluidic platforms by integrating them with microscale sensors, interfaces, and actuators to form autonomous hybrid systems. [10,12,16] Adding interface electronics to the same CMOS chip as sensors, actuators, data processing, and communication capabilities creates a universal platform for LOC technologies. Having signal amplification and noise removal right at the sensor interface without any signal loss makes the device output more accurate and sensitive, and also removes parasitic and mismatch errors. [1] By using CMOScompatible processes, it is possible to interface directly with the readout circuitry to form an integrated circuit system on a single chip. Signal acquisition from a large array of sensors to a single system requires a complex integration scheme, but CMOS microfabrication processes enable the integration of analogue multiplexers with biosensors on small dice. [19] CMOS also has the capability to actuate pumps and valves in microfluidic devices or to directly influence the fluid itself using electric With the increased global population, it is more important than ever to expand accessibility to affordable personalized healthcare. In this context, a seamless integration of microfluidic technology for bioanalysis and drug delivery and complementary metal oxide semiconductor (CMOS) technology enabled data-management circuitry is critical. Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable persona...

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Section: Role Of Cmos In Microfluidicsmentioning

confidence: 99%

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

et al. 2018

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“…Moreover, most existing flow cytometers rely on nonimaging techniques for cell recognition, hence are intrinsically less accurate than microscopy analysis. With the recent advancement in microfluidics based lab-on-a-chip technology, microfluidics-based lensless imaging system [7][8][9][10][11][12][13][14] provides a promising alternative to develop imaging-based micro-flow cytometer with system minimization.…”

Section: Introductionmentioning

confidence: 99%

“…The microfluidic lensless imaging system in [7][8][9][10][11][12][13][14] directly integrates microfluidic device on top of CMOS image sensor [14][15] in close proximity. The cells flow through a transparent poly-dimenthyl-siloxane (PDMS) microfluidic channel with spatially incoherent broadband white light illuminated from above.…”

Section: Introductionmentioning

confidence: 99%

A robust recognition error recovery for micro-flow cytometer by machine-learning enhanced single-frame super-resolution processing

Huang

Wang

Yan

et al. 2015

Integration, the VLSI Journal

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“…Integration of nanomaterials, microfluidics, automatic samplers, and transduction devices on a single chip provides many advantages for POC devices such as biosensors. Making use of specially designed microsystems [ 1 ], patients can be monitored continuously at bed side or at the general practitioner, and save precious time in commuting between home, doctor and hospital. The technological advancements in cell-based biosensors have accelerated the R&D in POC devices.…”

Section: Introductionmentioning

confidence: 99%

Cell-Based Biosensors: Electrical Sensing in Microfluidic Devices

Kiilerich-Pedersen

Rozlosnik

2012

Diagnostics

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Cell-based biosensors provide new horizons for medical diagnostics by adopting complex recognition elements such as mammalian cells in microfluidic devices that are simple, cost efficient and disposable. This combination renders possible a new range of applications in the fields of diagnostics and personalized medicine. The review looks at the most recent developments in cell-based biosensing microfluidic systems with electrical and electrochemical transduction, and relevance to medical diagnostics.

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High-speed CMOS image sensor for high-throughput lensless microfluidic imaging system

Cited by 11 publications

References 10 publications

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

CMOS Enabled Microfluidic Systems for Healthcare Based Applications

A robust recognition error recovery for micro-flow cytometer by machine-learning enhanced single-frame super-resolution processing

Cell-Based Biosensors: Electrical Sensing in Microfluidic Devices

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