Quantum communication aims to provide absolutely secure transmission of secret information. State-of-the-art methods encode symbols into single photons or coherent light with much less than one photon on average. For long distance communication, typically a singlemode fiber is used and significant effort has been devoted already to increase the data carrying capacity of a single optical line. Here we propose and demonstrate a fundamentally new concept for remote key establishment. Our method allows high-dimensional alphabets using spatial degrees of freedom by transmitting information through a light-scrambling multimode fiber and exploiting the no-cloning theorem. Eavesdropper attacks can be detected without using randomly switched mutually unbiased bases. We prove the security with single-photon Fock states and with weak coherent light. Since it is optical fiber based, our method allows to naturally extend secure communication to larger distances. We experimentally demonstrate this new type of key exchange method by encoding information into a few-photon light pulse decomposed over guided modes of an easily available multimode fiber. dimensional QKD [8]. A step-index multimode (MM) fiber supports a significantly higher number of modes than a multicore fiber and as a result can transfer information at a higher density. Another method for secure communication relies on optical reciprocity in MM fibers scrambling wavefronts in a random way [9].Although short pieces of straight or slightly bent fiber are not truly random [10], in any realistic fiber random bends, index imperfections, and other perturbations cause the signal to couple into multiple modes [11], leading to an arbitrary mixing of field amplitudes [12] and scrambling the information across the modes. However, it is well-known that the mode mixing can be partially undone by applying techniques from complex wavefront shaping, a method originally developed for precise light control through and in highly scattering materials [13][14][15]. Recently methods have been proposed for high-speed [16], high-resolution [17,18] image transfer. Multimode optical fibers can now also be used to transmit information in the spatial domain [19][20][21]. However, these methods are not secure.Here we propose a new method for secure key establishment via a MM fiber. The idea is based on secure characterization of the multimode transmission channel by means of weak light pulses. As can be seen in Fig. 1, both the sender, Alice, and the receiver, Bob, control a stretch of fiber that is randomly bent so that it spatially scrambles the optical communication signal. Our method is designed such that: 1) Alice and Bob can characterize the scrambled communication channel in a calibration phase and undo the scrambling using complex wavefront shaping in the communication phase. 2) By merit of the no-cloning theorem, Eve cannot decode the signal without physically reproducing the exact configuration of the scramblers used by Alice and Bob. 3) By merit of the same theorem, Eve cannot det...