High-speed on-demand 3D printed bioresorbable vascular scaffolds

Ware, Henry Oliver T.; Farsheed, Adam C.; Akar, Banu; Duan, Chongwen; Chen, Xiangfan; Ameer, Guillermo A.; Sun, Cheng

doi:10.1016/j.mtchem.2017.10.002

Cited by 66 publications

(50 citation statements)

References 33 publications

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“…The curing characteristics of the magnetic resin were measured experimentally using the well‐established speed working curve method for μCLIP process . However, as the presence of magnetic nanoparticles strongly absorbs the incident UV light, the light penetration into the magnetic resin has been significantly reduced.…”

Section: Resultsmentioning

confidence: 99%

“…Curing depth model for single exposure in SL process was well established as follows

{normalC}_{normald} {= D}_{normalp} \times \ln (\frac{E_{\exp}}{E_{c}})

where C d is the curing depth of a single exposure, D p is the penetration depth of the projected UV light, E c is the critical energy density necessary for polymerization to occur, and E exp is the total energy density projected to the photopolymerizable resin surface. As μCLIP is a continuous printing process, instead of repeating single exposures layer by layer, the curing depth could be determined by the speed‐working curing method in our previous work

{normalC}_{normald} {= D}_{normalp} \times \ln (\frac{v_{c}}{v_{s}})

where v c is the critical building plate moving speed and v s is the building plate actual moving speed.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Figure , the home‐made μCLIP system comprised a computer for process control, a light engine projection system (Pro 4500; Wintech Digital Systems Technology Corp.) featuring 385 nm UV light and 1280 × 800 pixel resolution, a CCD camera (DCC1645C; Thorlabs Inc.), a UV optical lens (UV8040BK2; Universe Kogaku America Inc.), a motorized Z‐stage, and a resin vat mounted with a 70 μm‐thick Teflon AF 2400 membrane (Teflon AF 2400x; Biogeneral Inc.) as the O 2 permeable window for μCLIP process . This system provided a building area of 9.70 × 6.06 mm 2 with spatial resolution of 7.58 × 7.58 μm 2 pixel −1 , which allowed for 3D printing millimeter‐size devices with fine features at microscale.…”

Section: Methodsmentioning

confidence: 99%

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Rapid 3D Printing Magnetically Active Microstructures with High Solid Loading

Shao

Ware

et al. 2019

Adv Eng Mater

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The capability of fabricating magnetically active 3D microstructures is crucial for miniaturization of microrobots or microactuators. While additive manufacturing using magnetic nanoparticle‐infused polymer resin offers the highly desirable precision and flexibility, the difficulty in handling resin with higher solid loading of magnetic nanoparticles needed to maximize the magnetic actuation forces remains to be the main obstacle. The increased viscosity of the magnetic resin not only significantly reduces the fabrication speed, but also makes the process vulnerable to the precipitation of the suspended magnetic nanoparticles. Herein, a comprehensive solution that synergizes the optimization of magnetic photopolymerizable resin and the high‐speed 3D printing using microcontinuous liquid interface production (μCLIP) process is reported. An optimized magnetic photopolymerizable resin with 30 wt% solid loading of Fe3O4 nanoparticles is well dispersed over 72 h. Process characteristics of the magnetic photopolymerizable resins with variation in the solid loading of magnetic nanoparticles are investigated experimentally. The capability of 3D printing centimeter‐size samples with sub‐75 μm fine features using high solid loading (30 wt%) is also demonstrated. The increased printing speed using μCLIP significantly reduces the fabrication time to the order of minutes to hours, making the process more robust against the precipitation of the magnetic particles.

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Section: Resultsmentioning

confidence: 99%

“…Curing depth model for single exposure in SL process was well established as follows

{normalC}_{normald} {= D}_{normalp} \times \ln (\frac{E_{\exp}}{E_{c}})

{normalC}_{normald} {= D}_{normalp} \times \ln (\frac{v_{c}}{v_{s}})

where v c is the critical building plate moving speed and v s is the building plate actual moving speed.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Rapid 3D Printing Magnetically Active Microstructures with High Solid Loading

Shao

Ware

et al. 2019

Adv Eng Mater

Self Cite

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“…For example, Carbon, Inc. has developed photoresins based on silicone and medical polyurethane for dental applications . Citrate‐based photoresins were developed recently as photoresins for micro‐CLIP in the design of resorbable vascular scaffolds . Increasing focus on the use of multiphoton polymerization to design biomaterial scaffolds via AM has introduced a range of photopolymers amenable to multiphoton lithography…”

Section: Toolbox For Am Of Precision Biomaterialsmentioning

confidence: 99%

Additive Manufacturing of Precision Biomaterials

2019

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Biomaterials play a critical role in modern medicine as surgical guides, implants for tissue repair, and as drug delivery systems. The emerging paradigm of precision medicine exploits individual patient information to tailor clinical therapy. While the main focus of precision medicine to date is the design of improved pharmaceutical treatments based on “‐omics” data, the concept extends to all forms of customized medical care. This includes the design of precision biomaterials that are tailored to meet specific patient needs. Additive manufacturing (AM) enables free‐form manufacturing and mass customization, and is a critical enabling technology for the clinical implementation of precision biomaterials. Materials scientists and engineers can contribute to the realization of precision biomaterials by developing new AM technologies, synthesizing advanced (bio)materials for AM, and improving medical‐image‐based digital design. As the field matures, AM is poised to provide patient‐specific tissue and organ substitutes, reproducible microtissues for drug screening and disease modeling, personalized drug delivery systems, as well as customized medical devices.

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“…This technology has shown potential in precision medicine through a variety of acellular biomedical applications, including through the production of nerve conduits, resorbable stents, and dental implants . Koffler et al recently implemented this layerless fabrication method at the microscale to fabricate a complex central nervous system (CNS) structure for spinal cord repair .…”

Section: Advanced 3d Printing Technologiesmentioning

confidence: 99%

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

2019

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Advances in areas such as data analytics, genomics, and imaging have revealed individual patient complexities and exposed the inherent limitations of generic therapies for patient treatment. These observations have also fueled the development of precision medicine approaches, where therapies are tailored for the individual rather than the broad patient population. 3D printing is a field that intersects with precision medicine through the design of precision implants with patient‐directed shapes, structures, and materials or for the development of patient‐specific in vitro models that can be used for screening precision therapeutics. Toward their success, advances in 3D printing and biofabrication technologies are needed with enhanced resolution, complexity, reproducibility, and speed and that encompass a broad range of cells and materials. The overall goal of this progress report is to highlight recent advances in 3D printing technologies that are helping to enable advances important in precision medicine.

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High-speed on-demand 3D printed bioresorbable vascular scaffolds

Cited by 66 publications

References 33 publications

Rapid 3D Printing Magnetically Active Microstructures with High Solid Loading

Rapid 3D Printing Magnetically Active Microstructures with High Solid Loading

Additive Manufacturing of Precision Biomaterials

Recent Advances in Enabling Technologies in 3D Printing for Precision Medicine

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