“…Large volume injection (200 μL) with LC-HRMS was used by Postigo et al, for a new high-throughput method for determining 13 HAAs and 2,2-dichloropropanoic acid in drinking water. 169 Only 16 min was required for analysis; quantification limits were <1 μg/L for most, and no extraction was required. Carbonyl DBPs were the focus of a FT-ICR-MS method by Liu et al, who used a chemical derivatization (Girard's reagent) with isotope labeling to distinguish carbonyl compounds and carbonyl DBPs before and after ozonation, chlorination, and chloramination.…”