High-throughput Organometallic Chemistry: Chemical Approaches, Experimental Methods, and Screening Techniques

Valorisation of Glycerol as Renewable Feedstock: Comparison of the Exploration of Chemical Transformation Methods Aided by High Throughput Experimentation

“…Key advances over the past few years, like detection platforms and liquid-handling technologies have significantly increased throughput and reduced assay volumes in this field. Even screening of 100,000 samples per day in miniaturized assay volumes are a routine task [99][100][101].…”

Microreactor technology and process miniaturization for catalytic reactions—A perspective on recent developments and emerging technologies

“…Microreactor-based tools are already well demonstrated as stand-alone devices for high-throughput catalyst screening and combinatorial materials science (Bergh et al, 2000;Brummer et al, 2003;Maier, 2004;Murphy, 2007;Scheidtmann et al, 2001;Takeuchi et al, 2005). Due to increased process intensification offered by MRT, more traditional pilot-scale reactor systems and pilot plant systems may be replaced, at least in some cases, by smaller, faster responding, more flexible mini-plants with reduced capital and operating costs (Charpentier, 2005;Commenge et al, 2002;Hessel, 2005a;Mae, 2007;Pennemann et al, 2004a, b).…”

Organopalladium Catalysis as a Proving Ground for Data-Rich Approaches to Reaction Development and Quantitative Predictions

“…And a recent comprehensive review of HTE in organometallic chemistry and catalysis from 2006 to 2020 reveals cross-coupling (sum of all varieties) as the most frequently reported reaction type undergoing high-throughput screening . This is a stark contrast to the prior 10 years, where HTE for asymmetric hydrogenation and alkene polymerization were overwhelmingly more common . Finally, due to its clear dominance as a preferred method in medicinal chemistry, the patent literature contains millions of unique examples of Pd-catalyzed transformations across a wide swath of chemical space.…”