Chiral Separation Methods for Pharmaceutical and Biotechnological Products 2010
DOI: 10.1002/9780470608661.ch12
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High‐Throughput Screening and Method Development Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and CE

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Cited by 3 publications
(7 citation statements)
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References 101 publications
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“…The effect is believed to last longer in apolar mobile phases (as is the case in SFC) than when polar eluents are used. A combined use of acidic and basic additives is claimed to reduce the memory effect in HPLC [17,100,101]. However, up till now there are no reports in the literature on the investigation of the memory effects in SFC.…”
Section: Mobile Phasementioning
confidence: 96%
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“…The effect is believed to last longer in apolar mobile phases (as is the case in SFC) than when polar eluents are used. A combined use of acidic and basic additives is claimed to reduce the memory effect in HPLC [17,100,101]. However, up till now there are no reports in the literature on the investigation of the memory effects in SFC.…”
Section: Mobile Phasementioning
confidence: 96%
“…This is a phenomenon where additives, after their removal from the mobile phase, leave a trace on the chiral selector of the CSP, altering its initial properties [17]. For HPLC this memory effect has been extensively studied and different rinsing procedures and additive uses were proposed [90][91][92][93][94][95].…”
Section: Mobile Phasementioning
confidence: 99%
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“…The main difference between SFC and HPLC is the use of the supercritical fluid as MP, which usually consists of carbon dioxide with a modifier. Advantages of SFC over HPLC are that less organic solvent is required for the analysis because the main part of the MP is carbon dioxide, and that a faster analysis is obtained because higher flow rates can be applied [32][33][34]. The SFC separation mechanism is similar to NPLC or HILIC, i.e.…”
Section: High Throughput Potential Of Sfcmentioning
confidence: 98%