High‐Throughput Synthesis of Polymers

Guerrero‐Sánchez, Carlos; Zhang, Junliang; Vitz, Jürgen; Schubert, Ulrich S.

doi:10.1002/0471440264.pst668

Cited by 5 publications

(2 citation statements)

References 113 publications

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“…To this end, a successful digitalization of the polymer R&D process will undoubtedly require automating and/or parallelizing in a reliable manner different experimental tasks, such as synthesis, characterization, purification, and testing of polymer materials. First approaches toward this ultimate goal have shown progress in establishing efficiently automated and/or parallel experimental protocols for the synthesis and characterization of polymer libraries employing combinatorial, highthroughput/-output (HT/O), or flow chemistry techniques [2][3][4]. Nonetheless, HT/O experimentation, as used nowadays in different polymer laboratories, currently faces obstacles that need to be addressed to contribute to the establishment of fully automated and/or parallelized experimental workflows necessary to progress the digitalization of R&D in this field.…”

Section: Introductionmentioning

confidence: 99%

Automated Parallel Dialysis for Purification of Polymers

et al. 2022

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The implementation of a dialysis method for the simultaneous purification of different polymer materials in a commercially available automated parallel synthesizer (APS) is discussed. The efficiency of this “unattended” automated parallel dialysis (APD) method was investigated by means of proton nuclear magnetic resonance (1H-NMR) measurements, which confirmed that the method enables the removal of up to 99% of the unreacted monomer derived from the synthesis of the corresponding polymers in the APS. Size-exclusion chromatography (SEC) revealed that the molar mass and molar mass distribution of the investigated polymers did not undergo significant changes after the application of the APD method. The method discussed herein can be regarded as a good alternative to the “unattended” and reliable purification of polymer libraries prepared in APS. This method may be useful for overcoming current limitations of high-throughput/-output (HT/O) synthesis of polymer libraries, where purification of the generated materials currently represents a significant constraint for establishing fully automated experimental workflows necessary to advance towards a full digitalization of research and development of new polymers for diverse applications.

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Section: Introductionmentioning

confidence: 99%

Automated Parallel Dialysis for Purification of Polymers

et al. 2022

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“…Consequently, synthetic robots are well-known in the field of polymer synthesis as well as polymer formulation and have been used for a variety of processes. [20,21] However, most of the syntheses performed nowadays are still classical ones using flasks and other classical laboratory glassware. In addition, catalysis represents a research field with a strong utilization of combinatorial approaches.…”

Section: Introductionmentioning

confidence: 99%

Digital Transformation in Materials Science: A Paradigm Change in Material's Development

2021

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The ongoing digitalization is rapidly changing and will further revolutionize all parts of life. This statement is currently omnipresent in the media as well as in the scientific community; however, the exact consequences of the proceeding digitalization for the field of materials science in general and the way research will be performed in the future are still unclear. There are first promising examples featuring the potential to change discovery and development approaches toward new materials. Nevertheless, a wide range of open questions have to be solved in order to enable the so‐called digital‐supported material research. The current state‐of‐the‐art, the present and future challenges, as well as the resulting perspectives for materials science are described.

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High‐Throughput/High‐Output Experimentation in Polymer Research

Lechuga‐Islas¹,

Guerrero‐Sánchez²,

Guerrero‐Santos³

et al. 2022

Macromolecular Engineering

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High‐throughput and high‐output experimental techniques represent suitable approaches to facilitate and speed up the preparation, optimization, and investigation of polymeric materials and polymerization processes. High‐throughput and high‐output screenings (HT/HO) are now recognized as highly efficient and cost‐effective techniques providing clear opportunities for the elucidation of structure–property relationships in polymer libraries. A wide range of important parameters can be investigated with systematic variations of properties, such as molar mass, dispersity, composition, microstructure, and other application‐specific properties. Moreover, the implementation of effective offline and online characterization techniques in HT/HO workflows has enabled the development of practical and productive methodologies. In recent years, HT/HO approaches have been actively pursued especially by the continuous development of reversible deactivation radical polymerization techniques. The synergy of such techniques, and the further development of computational and data management methods, could facilitate the fast access to complex and well‐defined polymeric materials in highly effective procedures. This contribution outlines the framework of the current status of high‐throughput and high‐output screenings for the synthesis and characterization of polymeric materials. Emphasis is placed on the advantages, current limitations, and the possible extensions and perspectives discussed in the current literature.

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High‐Throughput Synthesis of Polymers

Cited by 5 publications

References 113 publications

Automated Parallel Dialysis for Purification of Polymers

Automated Parallel Dialysis for Purification of Polymers

Digital Transformation in Materials Science: A Paradigm Change in Material's Development

High‐Throughput/High‐Output Experimentation in Polymer Research

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