High titer l -lactic acid production from corn stover with minimum wastewater generation and techno-economic evaluation based on Aspen plus modeling

Liu, Gang; Sun, Jiaoe; Zhang, Jian; Tu, Yi Fan; Bao, Jie

doi:10.1016/j.biortech.2015.09.098

Cited by 79 publications

(57 citation statements)

References 25 publications

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“…In contrast, high-titer LA production was obtained from sulfuric acid-pretreated and biodetoxified corn stover by P. acidilactici DQ2. In their studies, acid-pretreated corn stover was subsequently detoxified by inoculation of Amorphotheca resinae ZN1 for 5 days in a separated fermentation process and then the biodetoxified corn stover was used for LA fermentation2425. Thus, it should be considered to combine NH 3 -H 2 O 2 pretreatment with biodetoxification to enhance LA fermentation by B. coagulans FL204 in our further study.…”

Section: Resultsmentioning

confidence: 99%

“…A high titer (104.4 g/L) of l -LA was obtained from dilute acid-pretreated and biodetoxified corn stover with <30% solid content using an engineered P. acidilactici TY112 (CGMCC 8664) strain. The yield reached 0.72 g/g glucose from total corn stover without considering xylose unavailability24.…”

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confidence: 95%

“…However, the major disadvantage of these studies is the substantial volume of waste washing water generated by inhibitor removal. In terms of industrial production, wastewater should be strictly limited because of the high cost of wastewater treatment24. In contrast, significant LA production was obtained from sulfuric acid-pretreated and biodetoxified corn stover by Pediococcus acidilactici DQ2.…”

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confidence: 99%

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Comparison of high-titer lactic acid fermentation from NaOH- and NH3-H2O2-pretreated corncob by Bacillus coagulans using simultaneous saccharification and fermentation

Zhang

Xie

et al. 2016

Sci Rep

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Lignocellulose is one of the most abundant renewable feedstocks that has attracted considerable attention as a substrate for biofuel and biochemical production. One such biochemical product, lactic acid, is an important fermentation product because of its great potential for the production of biodegradable and biocompatible polylactic acid. High-titer lactic acid production from lignocellulosic materials has been achieved recently; however, it requires biodetoxification or results in large amounts of waste washing water. In this study, we employed two alkaline pretreatment methods and compared their effects on lactic acid fermentation of pretreated corncob by Bacillus coagulans LA204 using fed-batch simultaneous saccharification and fermentation under non-sterile conditions. The lactic acid titer, yield, and productivity from 16% (w/w) NaOH-pretreated and washed corncob were 122.99 g/L, 0.77 g/g corncob, and 1.37 g/L/h, respectively, and from 16% NH3-H2O2-pretreated and washed corncob were 118.60 g/L, 0.74 g/g corncob, and 1.32 g/L/h, respectively. Importantly, the lactic acid titer, yield, and productivity from 18.4% NH3-H2O2-pretreated and unwashed corncob by using fed-batch simultaneous saccharification and fermentation reached 79.47 g/L, 0.43 g/g corncob, and 1.10 g/L/h, respectively, demonstrating that this method is possible for industrial applications and saves washing water.

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Section: Resultsmentioning

confidence: 99%

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confidence: 95%

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confidence: 99%

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Comparison of high-titer lactic acid fermentation from NaOH- and NH3-H2O2-pretreated corncob by Bacillus coagulans using simultaneous saccharification and fermentation

Zhang

Xie

et al. 2016

Sci Rep

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“…The commercial prices of food grade lactic acid range between 1.38 $ kg −1 for 50 wt% to 1.90 $ kg −1 for 88 wt%, and cost for technical grade lactic acid with 88 wt% range between 1.59 and 1.88 $ kg −1 . The lactic acid production cost is targeted to be less than 0.9 $ kg −1 . Numerous economic studies of lactic acid production have been reported as presented in Table .…”

Section: Economic Aspectsmentioning

confidence: 99%

Potential and assessment of lactic acid production and isolation - a review

Jantasee

Kienberger

Mungma

et al. 2017

J. Chem. Technol. Biotechnol

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The majority of commodity plastics is made from petroleum-based chemicals. Lactic acid serves as a monomer for the production of the biodegradable polymer polylactic acid (PLA). This paper provides a review on the state of the art production and isolation process for lactic acid. Problems in production and isolation have been identified, the relevant results in optimized production are presented in the first part of the paper. In the second part, a decision matrix is used as a guideline for the discussion on the state of research in the isolation and purification of lactic acid. Mechanical unit operations, mass transfer unit operations, reactive separation techniques, and process combinations are reported in the literature. At the end, an economic evaluation of isolation processes such as conventional precipitation, reactive membrane separation, and reactive distillation are presented.

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“…Processes featuring biomass pretreatment (through physical and/or chemical and/or enzymatic approach) followed by microbial fermentation of soluble sugars to LA can be highly efficient, with LA yields close to the theoretical maximum at nearly optical purity . However, biomass pre‐treatment has significant cost and, in particular, the cost of cellulases is among the highest in the entire process . This currently makes industrial production of LA through fermentation of lignocellulose hardly viable from an economic standpoint.…”

Section: Introductionmentioning

confidence: 99%

Metabolic engineering strategies for consolidated production of lactic acid from lignocellulosic biomass

Mazzoli

2020

Biotech and App Biochem

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Lactic acid (LA) is one of the most desired molecules by the chemical industry. Current expansion of LA market is mainly driven by its application as building block for the synthesis of polylactide (PLA), that is, a family of biodegradable and biocompatible plastic polymers. PLA can potentially replace oil‐derived polymers as general purpose plastic, but current LA prices fails to make PLA cost‐competitive with traditional plastics. Nowadays, LA is mainly produced by fermentation of expensive starchy biomass. Hopefully, cheaper lignocellulosic feedstock could be used in future second‐generation biorefinery processes. However, most efficient natural LA producers cannot ferment lignocellulose without prior biomass saccharification. Metabolic engineering may develop improved microorganisms that feature both efficient biomass hydrolysis and LA production, thus supporting consolidated bioprocessing (CBP), that is, one‐pot fermentation, of lignocellulose to LA. CBP could dramatically reduce LA production cost, thus contributing to the expansion of more environmental sustainable plastics and commodity chemicals. This review presents an overview of “recombinant cellulolytic strategies”, mainly consisting in introducing cellulase systems in native producers of LA, and “native cellulolytic strategies” aimed at improving LA production in natural cellulolytic microorganisms. Issues and perspectives of these approaches will be discussed.

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High titer l -lactic acid production from corn stover with minimum wastewater generation and techno-economic evaluation based on Aspen plus modeling

Cited by 79 publications

References 25 publications

Comparison of high-titer lactic acid fermentation from NaOH- and NH3-H2O2-pretreated corncob by Bacillus coagulans using simultaneous saccharification and fermentation

Comparison of high-titer lactic acid fermentation from NaOH- and NH3-H2O2-pretreated corncob by Bacillus coagulans using simultaneous saccharification and fermentation

Potential and assessment of lactic acid production and isolation - a review

Metabolic engineering strategies for consolidated production of lactic acid from lignocellulosic biomass

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